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dc.contributor.authorEmblem, Åse
dc.contributor.authorKnutsen, Erik
dc.contributor.authorJørgensen, Tor Erik
dc.contributor.authorFure, Hilde
dc.contributor.authorJohansen, Steinar Daae
dc.contributor.authorBrekke, Ole Lars
dc.contributor.authorMollnes, Tom Eirik
dc.contributor.authorKarlsen, Bård Ove
dc.date.accessioned2022-08-22T08:11:55Z
dc.date.available2022-08-22T08:11:55Z
dc.date.issued2022-03-29
dc.description.abstractMany severe inflammation conditions are complement-dependent with the complement component C5a-C5aR1 axis as an important driver. At the RNA level, the blood transcriptome undergoes programmed expression of coding and long non-coding RNAs to combat invading microorganisms. Understanding the expression of long non-coding RNAs containing Alu elements in inflammation is important for reconstructing cell fate trajectories leading to severe disease. We have assembled a pipeline for computation mining of new Alu-containing long non-coding RNAs by intersecting immune genes with known Alu coordinates in the human genome. By applying the pipeline to patient bulk RNA-seq data with sepsis, we found immune genes containing 48 Alu insertion as robust candidates for further study. Interestingly, 1 of the 48 candidates was located within the complement system receptor gene C5aR1 and holds promise as a target for RNA therapeutics.en_US
dc.identifier.citationEmblem Å, Knutsen E, Jørgensen TE, Fure H, Johansen S.D., Brekke O.L., Mollnes TE, Karlsen B. Blood Transcriptome Analysis of Septic Patients Reveals a Long Non-Coding Alu-RNA in the Complement C5a Receptor 1 Gene . Non-coding RNA. 2022en_US
dc.identifier.cristinIDFRIDAID 2040218
dc.identifier.doihttps://doi.org/10.3390/ncrna8020024
dc.identifier.issn2311-553X
dc.identifier.urihttps://hdl.handle.net/10037/26299
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.relation.journalNon-coding RNA
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2022 The Author(s)en_US
dc.titleBlood Transcriptome Analysis of Septic Patients Reveals a Long Non-Coding Alu-RNA in the Complement C5a Receptor 1 Geneen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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