Show simple item record

dc.contributor.advisorLøberg, Else-Marie
dc.contributor.authorMørkved, Nina
dc.date.accessioned2022-08-22T21:46:30Z
dc.date.available2022-08-22T21:46:30Z
dc.date.issued2022-09-15
dc.description.abstractAn increasing body of research points to the importance of childhood trauma (CT) in psychosis, and as a risk factor for schizophrenia spectrum disorders (SSDs). The aim of this thesis was to investigate and compare the frequency and severity of CT in relation to clinical aspects and treatment outcomes in SSDs. The Childhood Trauma Questionnaire Short-Form (CTQ-SF) was used to retrospectively measure overall exposure to CT and CT subtypes (physical, sexual, and emotional abuse, and physical and emotional neglect). Paper I examined the specificity of CT in SSDs, and showed no group differences between patients with SSDs and patients with substance use disorders (SUDs) when comparing CTQ-SF sum and subscale scores, as well as no differences in the frequency and severity in the reported CT. Paper II examined the potential effect of CT on cognition in SSDs. No overall group differences emerged between SSD patients with CT compared to those reporting no CT. However, the CT subtype physical neglect predicted impaired attention/working memory abilities in SSDs. Paper III examined the influence of CT on general and differential antipsychotic effectiveness in SSDs. There were no differences for general antipsychotic effectiveness at 52 weeks for SSDs patients with CT as compared to the no CT group. However, for the olanzapine subgroup, the CT group showed less decrease in overall psychosis symptoms form baseline to 12, 26, 39 and 52 weeks. Findings from the current thesis suggest that CT is frequently reported in SSDs, although not unique nor specific for SSDs in comparison to SUDs. The CT subtype neglect appears to be related to clinically relevant features associated with SSDs such as cognitive performance, possibly reflecting a cognitive vulnerability for psychosis. Additionally, our findings indicate that CT may be associated with a slower antipsychotic treatment response to olanzapine in SSDs, even though the overall effect of CT was minimal. Clinicians and patients with SSDs and SUDs could benefit from integrating information regarding CT exposure in routine clinical settings.en_US
dc.description.doctoraltypeph.d.en_US
dc.description.popularabstractEarly experience of abuse and neglect, known as childhood trauma (CT), increases the risk of schizophrenia and other forms of psychoses. Psychosis may involve hallucinations, delusions, social withdrawal, and problems with memory and problem solving. This thesis aimed to look at the influence of CT in severe mental illnesses, such as psychosis. We found that CT was common both in adults with psychosis, and in people with substance abuse disorders. We also found that physical neglect by caregivers was related to cognitive problems in psychosis. CT did not appear to make a difference in symptom relief for people with psychosis whom received antipsychotic medication as part of their treatment. However, one of the antipsychotic drugs in our study, Olanzapine, was less effective in persons with psychosis and CT. Overall, our findings highlight the importance of trauma-informed care for persons with severe mental illnesses including psychosis.en_US
dc.description.sponsorshipNorthern Norway Regional Health Authority #PFP1300-16en_US
dc.identifier.isbn978-82-7589-877-5
dc.identifier.urihttps://hdl.handle.net/10037/26330
dc.language.isoengen_US
dc.publisherUiT The Arctic University of Norwayen_US
dc.publisherUiT Norges arktiske universiteten_US
dc.relation.haspart<p>Paper I: Mørkved, N., Winje, D., Dovran, A., Arefjord, K., Johnsen, E., Kroken, R.A., … Løberg, E.M. (2018). Childhood trauma in schizophrenia spectrum disorders as compared to substance abuse disorders. <i>Psychiatry Research, 261</i>, 481-487. Also available at <a href=https://doi.org/10.1016/j.psychres.2018.01.011>https://doi.org/10.1016/j.psychres.2018.01.011</a>. <p>Paper II: Mørkved, N., Johnsen, E., Kroken, R.A., Gjestad, R., Winje, D., Thimm, J.C., … Løberg, E.M. (2020). Does childhood trauma influence cognitive functioning in schizophrenia? The association of childhood trauma and cognition in schizophrenia spectrum disorders. <i>Schizophrenia Research: Cognition, 21</i>, 100179. Also available in Munin at <a href=https://hdl.handle.net/10037/19978>https://hdl.handle.net/10037/19978</a>. <p>Paper III: Mørkved, N., Johnsen, E., Kroken, R.A., Winje, D., Larsen, T.K., Thimm, J.C., … Løberg, E.M. Impact of childhood trauma on general and differential antipsychotic effectiveness in schizophrenia spectrum disorders: A prospective, pragmatic, semi-randomized trial. (Submitted manuscript). Now published in <i>Schizophrenia Research, 2022, 246</i>, 49-59, available at <a href= https://doi.org/10.1016/j.schres.2022.05.022>https://doi.org/10.1016/j.schres.2022.05.022</a>.en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2022 The Author(s)
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0en_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)en_US
dc.subjectVDP::Samfunnsvitenskap: 200::Psykologi: 260en_US
dc.subjectVDP::Social science: 200::Psychology: 260en_US
dc.subjectVDP::Samfunnsvitenskap: 200::Psykologi: 260::Klinisk psykologi: 262en_US
dc.subjectVDP::Social science: 200::Psychology: 260::Clinical psychology: 262en_US
dc.subjectPsykiatrien_US
dc.subjectPsychiatryen_US
dc.titleChildhood Trauma in Schizophrenia Spectrum Disorders: A comparison to substance abuse disorders, and relation to cognitive performance and antipsychotic treatment outcomesen_US
dc.typeDoctoral thesisen_US
dc.typeDoktorgradsavhandlingen_US


File(s) in this item

Thumbnail
Thumbnail

This item appears in the following collection(s)

Show simple item record

Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)