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dc.contributor.authorCook, Sarah
dc.contributor.authorSolbu, Marit Dahl
dc.contributor.authorEggen, Anne Elise
dc.contributor.authorIakunchykova, Olena
dc.contributor.authorAverina, Maria
dc.contributor.authorHopstock, Laila Arnesdatter
dc.contributor.authorKholmatova, Kamila Kahramonzhonovna
dc.contributor.authorKudryavtsev, Alexander V
dc.contributor.authorLeon, David A.
dc.contributor.authorMalyutina, Sofia
dc.contributor.authorRyabikov, Andrew
dc.contributor.authorWilliamson, Elizabeth
dc.contributor.authorNitsch, Dorothea
dc.date.accessioned2022-08-25T12:40:04Z
dc.date.available2022-08-25T12:40:04Z
dc.date.issued2022-04-14
dc.description.abstractBackground - Little data exists on the prevalence of chronic kidney disease (CKD) in the Russian population. We aimed to estimate the prevalence of CKD in a population-based study in Russia, compare with a similar study in Norway, and investigate whether differences in risk factors explained between-study differences in CKD.<p> <p>Methods - We compared age- and sex-standardised prevalence of reduced eGFR (< 60 ml/min/1.73m2 CKD-EPI creatinine equation), albuminuria and or a composite indicator of CKD (one measure of either reduced eGFR or albuminuria) between participants aged 40–69 in the population-based Know Your Heart (KYH) study, Russia (2015–2018 N = 4607) and the seventh Tromsø Study (Tromsø7), Norway (2015–2016 N = 17,646). We assessed the contribution of established CKD risk factors (low education, diabetes, hypertension, antihypertensive use, smoking, obesity) to between-study differences using logistic regression.<p> <p>Results - Prevalence of reduced eGFR or albuminuria was 6.5% (95% Confidence Interval (CI) 5.4, 7.7) in KYH and 4.6% (95% CI 4.0, 5.2) in Tromsø7 standardised for sex and age. Odds of both clinical outcomes were higher in KYH than Tromsø7 (reduced eGFR OR 2.06 95% CI 1.67, 2.54; albuminuria OR 1.54 95% CI 1.16, 2.03) adjusted for sex and age. Risk factor adjustment explained the observed between-study difference in albuminuria (OR 0.92 95% CI 0.68, 1.25) but only partially reduced eGFR (OR 1.42 95% CI 1.11, 1.82). The strongest explanatory factors for the between-study difference was higher use of antihypertensives (Russian sample) for reduced eGFR and mean diastolic blood pressure for albuminuria.<p> <p>Conclusions - We found evidence of a higher burden of CKD within the sample from the population in Arkhangelsk and Novosibirsk compared to Tromsø, partly explained by between-study population differences in established risk factors. In particular hypertension defined by medication use was an important factor associated with the higher CKD prevalence in the Russian sample.en_US
dc.identifier.citationCook, Solbu, Eggen, Iakunchykova, Averina, Hopstock, Kholmatova, Kudryavtsev, Leon, Malyutina, Ryabikov, Williamson, Nitsch. Comparing prevalence of chronic kidney disease and its risk factors between population-based surveys in Russia and Norway. BMC Nephrology. 2022;23(1)en_US
dc.identifier.cristinIDFRIDAID 2028928
dc.identifier.doi10.1186/s12882-022-02738-2
dc.identifier.issn1471-2369
dc.identifier.urihttps://hdl.handle.net/10037/26429
dc.language.isoengen_US
dc.publisherBMCen_US
dc.relation.journalBMC Nephrology
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2022 The Author(s)en_US
dc.titleComparing prevalence of chronic kidney disease and its risk factors between population-based surveys in Russia and Norwayen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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