dc.contributor.author | Heldal, Torbjørn Fossum | |
dc.contributor.author | Åsberg, Anders | |
dc.contributor.author | Ueland, Thor | |
dc.contributor.author | Reisæter, Anna Varberg | |
dc.contributor.author | Pischke, Søren Erik | |
dc.contributor.author | Mollnes, Tom Eirik | |
dc.contributor.author | Aukrust, Pål | |
dc.contributor.author | Hartmann, Anders | |
dc.contributor.author | Heldal, Kristian | |
dc.contributor.author | Jenssen, Trond | |
dc.date.accessioned | 2022-08-26T09:38:06Z | |
dc.date.available | 2022-08-26T09:38:06Z | |
dc.date.issued | 2022-03-30 | |
dc.description.abstract | In the general population, low-grade inflammation has been established as a risk
factor for all-cause mortality. We hypothesized that an inflammatory milieu beyond
the time of recovery from the surgical trauma could be associated with increased
long-term mortality in kidney transplant recipients (KTRs). This cohort study included
1044 KTRs. Median follow-up time post-engraftment was 10.3 years. Inflammation
was assessed 10 weeks after transplantation by different composite inflammation
scores based on 21 biomarkers. We constructed an overall inflammation score and
five pathway-specific inflammation scores (fibrogenesis, vascular inflammation, metabolic inflammation, growth/angiogenesis, leukocyte activation). Mortality was assessed with Cox regression models adjusted for traditional risk factors. A total of 312
(29.9%) patients died during the follow-up period. The hazard ratio (HR) for death was 4.71 (95% CI: 2.85–7.81, p < .001) for patients in the highest quartile of the overall inflammation score and HRs 2.35–2.54 (95% CI: 1.40–3.96, 1.52–4.22, p = .001)
for patients in the intermediate groups. The results were persistent when the score
was analyzed as a continuous variable (HR 1.046, 95% CI: 1.033–1.056, p < .001). All
pathway-specific analyses showed the same pattern with HRs ranging from 1.19 to
2.70. In conclusion, we found a strong and consistent association between low-grade
systemic inflammation 10 weeks after kidney transplantation and long-term mortality. | en_US |
dc.identifier.citation | Heldal, Åsberg, Ueland, Reisæter, Pischke, Mollnes, Aukrust, Hartmann, Heldal, Jenssen. Inflammation in the early phase after kidney transplantation is associated with increased long-term all-cause mortality. American Journal of Transplantation. 2022 | en_US |
dc.identifier.cristinID | FRIDAID 2015929 | |
dc.identifier.doi | 10.1111/ajt.17047 | |
dc.identifier.issn | 1600-6135 | |
dc.identifier.issn | 1600-6143 | |
dc.identifier.uri | https://hdl.handle.net/10037/26438 | |
dc.language.iso | eng | en_US |
dc.publisher | Wiley | en_US |
dc.relation.journal | American Journal of Transplantation | |
dc.rights.accessRights | openAccess | en_US |
dc.rights.holder | Copyright 2022 The Author(s) | en_US |
dc.title | Inflammation in the early phase after kidney transplantation is associated with increased long-term all-cause mortality | en_US |
dc.type.version | publishedVersion | en_US |
dc.type | Journal article | en_US |
dc.type | Tidsskriftartikkel | en_US |
dc.type | Peer reviewed | en_US |