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dc.contributor.authorAalto, Nerea Johanna
dc.contributor.authorSchweitzer, Hannah D.
dc.contributor.authorKrsmanovic, Stina
dc.contributor.authorCampbell, Karley
dc.contributor.authorBernstein, Hans Christopher
dc.date.accessioned2022-08-30T08:01:14Z
dc.date.available2022-08-30T08:01:14Z
dc.date.issued2022-07-14
dc.description.abstractSerglycin is a proteoglycan highly expressed by immune cells, in which its functions are linked to storage, secretion, transport, and protection of chemokines, proteases, histamine, growth factors, and other bioactive molecules. In recent years, it has been demonstrated that serglycin is also expressed by several other cell types, such as endothelial cells, muscle cells, and multiple types of cancer cells. Here, we show that serglycin expression is upregulated in transforming growth factor beta (TGF-b) induced epithelial-mesenchymal transition (EMT). Functional studies provide evidence that serglycin plays an important role in the regulation of the transition between the epithelial and mesenchymal phenotypes, and it is a significant EMT marker gene. We further find that serglycin is more expressed by breast cancer cell lines with a mesenchymal phenotype as well as the basal-like subtype of breast cancers. By examining immune staining and single cell sequencing data of breast cancer tissue, we show that serglycin is highly expressed by infiltrating immune cells in breast tumor tissue.en_US
dc.identifier.citationAalto, Schweitzer HD, Krsmanovic S, Campbell KL, Bernstein HC. Diversity and Selection of Surface Marine Microbiomes in the Atlantic-Influenced Arctic. Frontiers in Microbiology. 2022;13en_US
dc.identifier.cristinIDFRIDAID 2046885
dc.identifier.doi10.3389/fmicb.2022.892634
dc.identifier.issn1664-302X
dc.identifier.urihttps://hdl.handle.net/10037/26466
dc.language.isoengen_US
dc.publisherFrontiers Mediaen_US
dc.relation.ispartofAalto, N.J. (2022). Atmospheric CO2 drawdown, community dynamics and selection of surface microbiomes in marine cold-water ecosystems. (Doctoral thesis). <a href=https://hdl.handle.net/10037/26900>https://hdl.handle.net/10037/26900</a>.
dc.relation.journalFrontiers in Microbiology
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2022 The Author(s)en_US
dc.titleDiversity and Selection of Surface Marine Microbiomes in the Atlantic-Influenced Arcticen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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