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dc.contributor.authorHenry, Cían J.
dc.contributor.authorSemova, Gergana
dc.contributor.authorBarnes, Ellen
dc.contributor.authorCotter, Isabel
dc.contributor.authorDevers, Tara
dc.contributor.authorRafaee, Aisyah
dc.contributor.authorSlavescu, Andreea
dc.contributor.authorCathain, Niamh O.
dc.contributor.authorMcCollum, Danielle
dc.contributor.authorRoche, Edna
dc.contributor.authorMockler, David
dc.contributor.authorAllen, John
dc.contributor.authorMeehan, Judith
dc.contributor.authorKlingenberg, Claus Andreas
dc.contributor.authorLatour, Jos M.
dc.contributor.authorvan den Hoogen, Agnes
dc.contributor.authorStrunk, Tobias
dc.contributor.authorGiannoni, Eric
dc.contributor.authorSchlapbach, Luregn J.
dc.contributor.authorDegtyareva, Marina
dc.contributor.authorPlötz, Frans B.
dc.contributor.authorde Boode, Willem P.
dc.contributor.authorNaver, Lars
dc.contributor.authorWynn, James L.
dc.contributor.authorKüster, Helmut
dc.contributor.authorJanota, Jan
dc.contributor.authorKeij, Fleur M.
dc.contributor.authorReiss, Irwin K. M.
dc.contributor.authorBliss, Joseph M.
dc.contributor.authorPolin, Richard
dc.contributor.authorKoenig, Joyce M.
dc.contributor.authorTurner, Mark A.
dc.contributor.authorGale, Christopher
dc.contributor.authorMolloy, Eleanor J.
dc.date.accessioned2022-08-31T07:18:18Z
dc.date.available2022-08-31T07:18:18Z
dc.date.issued2022-01-07
dc.description.abstractBACKGROUND: The lack of a consensus definition of neonatal sepsis and a core outcome set (COS) proves a substantial impediment to research that influences policy and practice relevant to key stakeholders, patients and parents.<p> <p>METHODS: A systematic review of the literature was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. In the included studies, the described outcomes were extracted in accordance with the provisions of the Core Outcome Measures in Effectiveness Trials (COMET) handbook and registered. <p>RESULTS: Among 884 abstracts identified, 90 randomised controlled trials (RCTs) were included in this review. Only 30 manuscripts explicitly stated the primary and/or secondary outcomes. A total of 88 distinct outcomes were recorded across all 90 studies included. These were then assigned to seven different domains in line with the taxonomy for classification proposed by the COMET initiative. The most frequently reported outcome was survival with 74% (n = 67) of the studies reporting an outcome within this domain. <p>CONCLUSIONS: This systematic review constitutes one of the initial phases in the protocol for developing a COS in neonatal sepsis. The paucity of standardised outcome reporting in neonatal sepsis hinders comparison and synthesis of data. The final phase will involve a Delphi Survey to generate a COS in neonatal sepsis by consensus recommendation.en_US
dc.identifier.citationHenry, Semova, Barnes, Cotter, Devers, Rafaee, Slavescu, Cathain, McCollum, Roche, Mockler, Allen, Meehan, Klingenberg, Latour, van den Hoogen, Strunk, Giannoni, Schlapbach, Degtyareva, Plötz, de Boode, Naver, Wynn, Küster, Janota, Keij, Reiss, Bliss, Polin, Koenig, Turner, Gale, Molloy. Neonatal sepsis: a systematic review of core outcomes from randomised clinical trials. Pediatric Research. 2022;91:735-742en_US
dc.identifier.cristinIDFRIDAID 2023068
dc.identifier.doi10.1038/s41390-021-01883-y
dc.identifier.issn0031-3998
dc.identifier.issn1530-0447
dc.identifier.urihttps://hdl.handle.net/10037/26481
dc.language.isoengen_US
dc.publisherSpringer Natureen_US
dc.relation.journalPediatric Research
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2022 The Author(s)en_US
dc.titleNeonatal sepsis: a systematic review of core outcomes from randomised clinical trialsen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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