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dc.contributor.authorCharles, Dolley
dc.contributor.authorBerg, Vivian
dc.contributor.authorNøst, Therese Haugdahl
dc.contributor.authorBergdahl, Ingvar A.
dc.contributor.authorHuber, Sandra
dc.contributor.authorAyotte, Pierre
dc.contributor.authorWilsgaard, Tom
dc.contributor.authorAverina, Maria
dc.contributor.authorSandanger, Torkjel M
dc.contributor.authorRylander, Charlotta
dc.date.accessioned2022-09-06T10:33:49Z
dc.date.available2022-09-06T10:33:49Z
dc.date.issued2021-09-28
dc.description.abstractBackground: Positive associations have been reported between persistent organic pollutants (POPs) and type 2 diabetes mellitus (T2DM); however, causality has not been established. Over the last decades, environmental exposure to legacy POPs has decreased, complicating epidemiological studies. In addition, physiological risk factors for T2DM may also influence POP concentrations, contributing to a complex network of factors that could impact associations with T2DM. Longitudinal studies on this topic are lacking, and few have assessed prospective and cross-sectional associations between repeated POP measurements and T2DM in the same individuals, which may shed light on causality.<p> <p>Objectives: To compare longitudinal trends in concentrations of polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs) in T2DM cases and controls, and to examine prospective and cross-sectional associations between PCBs, OCPs and T2DM at different time-points before and after T2DM diagnosis in cases. <p>Methods: We conducted a longitudinal, nested case-control study (1986–2016) of 116 T2DM cases and 139 controls from the Tromsø Study. All participants had three blood samples collected before T2DM diagnosis in cases, and up to two samples thereafter. We used linear mixed-effect models to assess temporal changes of POPs within and between T2DM cases and controls, and logistic regression models to investigate the associations between different POPs and T2DM at different time-points. <p>Results: PCBs, trans-nonachlor, cis-nonachlor, oxychlordane, cis-heptachlor epoxide, p,p’-DDE, and p,p’-DDT declined more slowly in cases than controls, whereas β-HCH and HCB declined similarly in both groups. Most POPs showed positive associations between both pre- and post-diagnostic concentrations and T2DM, though effect estimates were imprecise. These associations were most consistent for cis-heptachlor epoxide. <p>Discussion: The observed positive associations between certain POPs and T2DM may be because of higher POP concentrations within prospective T2DM cases, due to slower temporal declines as compared to controls.en_US
dc.identifier.citationCharles D, Berg V, Nøst TH, Bergdahl IA, Huber SH, Ayotte P, Wilsgaard T, Averina M, Sandanger TM, Rylander C. Longitudinal changes in concentrations of persistent organic pollutants (1986–2016) and their associations with type 2 diabetes mellitus. Environmental Research. 2022;204en_US
dc.identifier.cristinIDFRIDAID 1952168
dc.identifier.doi10.1016/j.envres.2021.112129
dc.identifier.issn0013-9351
dc.identifier.issn1096-0953
dc.identifier.urihttps://hdl.handle.net/10037/26658
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalEnvironmental Research
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2022 The Author(s)en_US
dc.titleLongitudinal changes in concentrations of persistent organic pollutants (1986–2016) and their associations with type 2 diabetes mellitusen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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