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dc.contributor.authorOhnstad, Mari Oma
dc.contributor.authorStensvold, Hans Jørgen
dc.contributor.authorPripp, Are Hugo
dc.contributor.authorTvedt, Christine Raaen
dc.contributor.authorJelsness-Jørgensen, Lars-Petter
dc.contributor.authorAstrup, Henriette
dc.contributor.authorEriksen, Beate Horsberg
dc.contributor.authorKlingenberg, Claus Andreas
dc.contributor.authorMreihil, Khalaf
dc.contributor.authorPedersen, Tanja
dc.contributor.authorRettedal, Siren
dc.contributor.authorSelberg, Terje Reidar
dc.contributor.authorSolberg, Rønnaug
dc.contributor.authorStøen, Ragnhild
dc.contributor.authorRønnestad, Arild Erland
dc.date.accessioned2022-09-06T11:49:24Z
dc.date.available2022-09-06T11:49:24Z
dc.date.issued2022-08-09
dc.description.abstractObjective The aim of the study was to investigate first extubation attempts among extremely premature (EP) infants and to explore factors that may increase the quality of clinical judgement of extubation readiness. Design and method A population-based study was conducted to explore first extubation attempts for EP infants born before a gestational age (GA) of 26 weeks in Norway between 1 January 2013 and 31 December 2018. Eligible infants were identified via the Norwegian Neonatal Network database. The primary outcome was successful extubation, defined as no reintubation within 72 hours after extubation. Results Among 482 eligible infants, 316 first extubation attempts were identified. Overall, 173 (55%) infants were successfully extubated, whereas the first attempt failed in 143 (45%) infants. A total of 261 (83%) infants were extubated from conventional ventilation (CV), and 55 (17%) infants were extubated from high-frequency oscillatory ventilation (HFOV). In extubation from CV, pre-extubation fraction of inspired oxygen (FiO2) ≤0.35, higher Apgar score, higher GA, female sex and higher postnatal age were important predictors of successful extubation. In extubation from HFOV, a pre-extubation FiO2 level ≤0.35 was a relevant predictor of successful extubation. Conclusions The correct timing of extubation in EP infants is important. In this national cohort, 55% of the first extubation attempts were successful. Our results suggest that additional emphasis on oxygen requirement, sex and general condition at birth may further increase extubation success when clinicians are about to extubate EP infants for the first time.en_US
dc.identifier.citationOhnstad MO, Stensvold HJ, Pripp Ah, Tvedt CR, Jelsness-Jørgensen LPJJ, Astrup H, Eriksen BH, Klingenberg C, Mreihil K, Pedersen T, Rettedal S, Selberg TR, Solberg R, Støen R, Rønnestad AE. Predictors of extubation success: a population-based study of neonates below a gestational age of 26 weeks. BMJ Paediatrics Open. 2022;6(1)en_US
dc.identifier.cristinIDFRIDAID 2042409
dc.identifier.doi10.1136/bmjpo-2022-001542
dc.identifier.issn2399-9772
dc.identifier.urihttps://hdl.handle.net/10037/26667
dc.language.isoengen_US
dc.publisherBMJ Publishing Groupen_US
dc.relation.journalBMJ Paediatrics Open
dc.relation.urihttp://dx.doi.org/10.1136/bmjpo-2022-001542
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2022 The Author(s)en_US
dc.titlePredictors of extubation success: a population-based study of neonates below a gestational age of 26 weeksen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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