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dc.contributor.authorBicakci, Ahmet Oguzhan
dc.contributor.authorSarkar, Mousumi
dc.contributor.authorChang, Yu-Hsin
dc.contributor.authorKahl, Evelyn
dc.contributor.authorRagazzi, Lorenzo
dc.contributor.authorMoldes-Anaya, Angel
dc.contributor.authorFendt, Markus
dc.date.accessioned2022-09-07T06:44:49Z
dc.date.available2022-09-07T06:44:49Z
dc.date.issued2022-02-16
dc.description.abstractPositive gamma-aminobutyric acid type B (GABAB) receptor modulators such as GS39783 have showed anxiolytic-like effects in several studies while such effects were absent in other studies. These conflicting findings led us hypothesize that the anxiolytic-like effects of such compounds depend on the individual basal anxiety and/or the anxiogenic properties of the used tests. The present study addresses this hypothesis by testing GS39783 effects on mice’s anxiety-like behavior in a light–dark box. We found that GS39783 had no effects on a whole-group level. However, after grouping the mice for their basal anxiety, GS39783 reduced anxiety-like behavior in the subgroup with highest basal anxiety. Moreover, GS39783 effects correlated with individual basal anxiety. Next, the anxiogenic properties of the light–dark box test were increased by prior stress exposure. Again, GS39783 was not effective on a whole-group level. However, GS39783 had an anxiolytic-like effect in the most stress-responsive subgroup. Moreover, GS39783 effects correlated with individual stress responsiveness. Finally, we show that GS39783 brain levels were within a behaviorally relevant range. Overall, our study demonstrates that GS39783 effects depend on individual basal anxiety and stress responsiveness. This suggests that anxiety tests should generally be designed to capture individual basal anxiety and/or stress responsiveness as well as individual compound effects.en_US
dc.identifier.citationBicakci, Sarkar, Chang, Kahl, Ragazzi L, Moldes-Anaya AS, Fendt. Anxiolytic-like Effects of the Positive GABA-B Receptor Modulator GS39783 Correlate with Mice's Individual Basal Anxiety and Stress Reactivity. Pharmaceuticals. 2022;15(2)en_US
dc.identifier.cristinIDFRIDAID 2021616
dc.identifier.doihttps://doi.org/10.3390/ph15020233
dc.identifier.issn1424-8247
dc.identifier.urihttps://hdl.handle.net/10037/26682
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.relation.journalPharmaceuticals
dc.relation.urihttps://www.mdpi.com/1424-8247/15/2/233
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2022 The Author(s)en_US
dc.titleAnxiolytic-like Effects of the Positive GABA-B Receptor Modulator GS39783 Correlate with Mice's Individual Basal Anxiety and Stress Reactivityen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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