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dc.contributor.authorSøraas, Arne Vasli
dc.contributor.authorGrødeland, Gunnveig
dc.contributor.authorGranerud, Beathe Kiland
dc.contributor.authorUeland, Thor
dc.contributor.authorLind, Andreas
dc.contributor.authorFevang, Børre
dc.contributor.authorMurphy, Sarah Louise Mikalsen
dc.contributor.authorHuse, Camilla
dc.contributor.authorNygaard, Anders Benteson
dc.contributor.authorSteffensen, Anne Katrine
dc.contributor.authorAl-Baldawi, Huda
dc.contributor.authorHolberg-Petersen, Mona
dc.contributor.authorAndresen, Lise Lima
dc.contributor.authorÅgnes, Camilla
dc.contributor.authorRanheim, Trine
dc.contributor.authorSchanke, Ylva
dc.contributor.authorIstre, Mette Stausland
dc.contributor.authorDahl, John Arne
dc.contributor.authorChopra, Adity
dc.contributor.authorDudman, Susanne
dc.contributor.authorKaarbø, Mari
dc.contributor.authorAndersen, Jan Terje
dc.contributor.authorVaage, Eline Benno
dc.contributor.authorTran, Trung The
dc.contributor.authorVaage, John Torgils
dc.contributor.authorMichelsen, Annika Elisabet
dc.contributor.authorMüller, Fredrik
dc.contributor.authorAukrust, Pål
dc.contributor.authorHalvorsen, Bente Evy
dc.contributor.authorDahl, Tuva Børresdatter
dc.contributor.authorHolter, Jan Cato
dc.contributor.authorLund-Johansen, Fridtjof
dc.date.accessioned2022-10-26T12:41:16Z
dc.date.available2022-10-26T12:41:16Z
dc.date.issued2022-09-08
dc.description.abstractBackground: Results showing that sera from double vaccinated individuals have minimal neutralizing activity against Omicron have been interpreted as indicating the need for a third vaccine dose for protection. However, there is little information about early immune responses to Omicron infection in double vaccinated individuals.<p> <p>Methods: We measured inflammatory mediators, antibodies to the SARS-CoV-2 spike and nucleocapsid proteins, and spike peptide-induced release of interferon gamma in whole blood in 51 double-vaccinated individuals infected with Omicron, in 14 infected with Delta, and in 18 healthy controls. The median time points for the first and second samples were 7 and 14 days after symptom onset, respectively. <p>Findings: Infection with Omicron or Delta led to a rapid and similar increase in antibodies to the receptor-binding domain (RBD) of Omicron protein and spike peptide-induced interferon gamma in whole blood. Both the Omicron- and the Delta-infected patients had a mild and transient increase in inflammatory parameters. <p<Interpretation: The results suggest that two vaccine doses are sufficient to mount a rapid and potent immune response upon infection in healthy individuals of with the Omicron variant.en_US
dc.identifier.citationSøraas, Grødeland, Granerud BK, Ueland, Lind, Fevang, Murphy, Huse, Nygaard, Steffensen, Al-Baldawi, Holberg-Petersen, Andresen, Ågnes, Ranheim, Schanke, Istre, Dahl, Chopra, Dudman, Kaarbø, Andersen, Vaage, Tran, Vaage, Michelsen, Müller, Aukrust, Halvorsen, Dahl, Holter, Lund-Johansen. Breakthrough infections with the omicron and delta variants of SARS-CoV-2 result in similar re-activation of vaccine-induced immunity. Frontiers in Immunology. 2022;13:1-12en_US
dc.identifier.cristinIDFRIDAID 2059925
dc.identifier.doi10.3389/fimmu.2022.964525
dc.identifier.issn1664-3224
dc.identifier.urihttps://hdl.handle.net/10037/27141
dc.language.isoengen_US
dc.publisherFrontiers Mediaen_US
dc.relation.journalFrontiers in Immunology
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FundingProgram/848099/EU/Molecular Mechanisms Associating Chronic Pain with Fatigue, Affective Disorders, Cardiovascular Disease and Total Comorbidity/PainFACT/en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2022 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.subjectVDP::Medisinske fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Medisinsk immunologi: 716en_US
dc.subjectVDP::Midical sciences: 700::Basic medical, dental and veterinary sciences: 710::Medical immunology: 716en_US
dc.subjectVDP::Medisinske fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Medisinsk mikrobiologi : 715en_US
dc.subjectVDP::Midical sciences: 700::Basic medical, dental and veterinary sciences: 710::Medical microbiology: 715en_US
dc.titleBreakthrough infections with the omicron and delta variants of SARS-CoV-2 result in similar re-activation of vaccine-induced immunityen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's license is described as Attribution 4.0 International (CC BY 4.0)