Vis enkel innførsel

dc.contributor.authorTorstveit, Ann Helen
dc.contributor.authorMiaskowski, Christine
dc.contributor.authorLøyland, Borghild
dc.contributor.authorGrov, Ellen Karine
dc.contributor.authorRitchie, Christine Seel
dc.contributor.authorPaul, Steven M
dc.contributor.authorEngh, Anna Marie Ellström
dc.contributor.authorUtne, Inger
dc.date.accessioned2022-11-11T10:19:13Z
dc.date.available2022-11-11T10:19:13Z
dc.date.issued2022-11-03
dc.description.abstractPurpose Study purposes were to evaluate for inter-individual variability in the trajectories of three objective measures of physical function (PF) in older patients receiving chemotherapy (n=112) and determine which characteristics were associated with worse PF.<p> <p>Methods Balance, gait speed, and chair-stand test were evaluated at initiation and 1, 3, 6, 9, and 12 months following chemotherapy. Hierarchical linear modeling was used to assess inter-individual variability in the trajectories of the three tests. Demographic, clinical, and symptom characteristics, and levels of cognitive function associated with initial levels and changes over time in each of the tests were determined. <p>Results Gait speed and chair-stand tests improved over time. Balance declined until month 6, then increased. Characteristics associated with decreases in balance scores at initiation of chemotherapy were lower level of education and lower Karnofsky Performance Status (KPS) score. For initial levels of poorer gait speed, older age, poorer Trail Making Test B (TMTB), and worse Attentional Function Index scores were the associated characteristics. Lower KPS scores, higher body mass index, and poorer TMTB scores were associated with poorer chair-stand times at initiation of chemotherapy. Worse trajectories of chair-stand times were associated with poorer chair-stand time at enrollment. Characteristic associated with lower initial levels and improved trajectories of balance was older age at enrollment. <p>Conclusions Determination of characteristics associated with decrements in balance, gait speed, and chair-stand can assist clinicians to identify older oncology patients at risk for decrements in PF. Interventions to maintain and improve PF need to be implemented with higher risk patients.en_US
dc.identifier.citationTorstveit AH, Miaskowski C, Løyland B, Grov EK, Ritchie CS, Paul SM, Engh ME, Utne I. Characteristics associated with decrements in objective measures of physical function in older patients with cancer during chemotherapy. Supportive Care in Cancer. 2022en_US
dc.identifier.cristinIDFRIDAID 2071544
dc.identifier.doihttps://doi.org/10.1007/s00520-022-07416-5
dc.identifier.issn0941-4355
dc.identifier.issn1433-7339
dc.identifier.urihttps://hdl.handle.net/10037/27338
dc.language.isoengen_US
dc.publisherSpringeren_US
dc.relation.journalSupportive Care in Cancer
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2022 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleCharacteristics associated with decrements in objective measures of physical function in older patients with cancer during chemotherapyen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


Tilhørende fil(er)

Thumbnail

Denne innførselen finnes i følgende samling(er)

Vis enkel innførsel

Attribution 4.0 International (CC BY 4.0)
Med mindre det står noe annet, er denne innførselens lisens beskrevet som Attribution 4.0 International (CC BY 4.0)