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dc.contributor.authorJohansen, Jeanette Schultz
dc.contributor.authorHalvorsen, Kjell H.
dc.contributor.authorSvendsen, Kristian
dc.contributor.authorHavnes, Kjerstin
dc.contributor.authorRobinson, Eirin Guldsten
dc.contributor.authorWetting, Hilde Ljones
dc.contributor.authorHaustreis, Stine
dc.contributor.authorSmåbrekke, Lars
dc.contributor.authorKamycheva, Elena
dc.contributor.authorGarcia, Beate Hennie
dc.date.accessioned2022-11-15T08:16:04Z
dc.date.available2022-11-15T08:16:04Z
dc.date.issued2022-10-26
dc.description.abstract<b><p>Background</b> Suboptimal medication use contributes to a substantial proportion of hospitalizations and emergency department visits in older adults. We designed a clinical pharmacist intervention to optimize medication therapy in older hospitalized patients. Based on the integrated medicine management (IMM) model, the 5-step IMMENSE intervention comprise medication reconciliation, medication review, reconciled medication list upon discharge, patient counselling, and post discharge communication with primary care. The objective of this study was to evaluate the effects of the intervention on healthcare use and mortality. <b><p>Methods</b> A non-blinded parallel group randomized controlled trial was conducted in two internal medicine wards at the University Hospital of North Norway. Acutely admitted patients ≥ 70 years were randomized 1:1 to intervention or standard care (control). The primary outcome was the rate of emergency medical visits (readmissions and emergency department visits) 12 months after discharge. <b><p>Results</b> Of the 1510 patients assessed for eligibility, 662 patients were asked to participate, and 516 were enrolled. After withdrawal of consent and deaths in hospital, the modified intention-to-treat population comprised 480 patients with a mean age of 83.1 years (SD: 6.3); 244 intervention patients and 236 control patients. The number of emergency medical visits in the intervention and control group was 497 and 499, respectively, and no statistically significant difference was observed in rate of the primary outcome between the groups [adjusted incidence rate ratio of 1.02 (95% CI: 0.82–1.27)]. No statistically significant differences between groups were observed for any of the secondary outcomes, neither in subgroups, nor for the per-protocol population. <b><p>Conclusions</b> We did not observe any statistical significant effects of the IMMENSE intervention on the rate of emergency medical visits or any other secondary outcomes after 12 months in hospitalized older adults included in this study.en_US
dc.identifier.citationJohansen JS, Halvorsen KH, Svendsen K, Havnes K, Robinson EG, Wetting, Haustreis S, Småbrekke L, Kamycheva E, Garcia BH. Interdisciplinary collaboration across secondary and primary care to improve medication safety in the elderly (The IMMENSE study) – a randomized controlled trial. BMC Health Services Research. 2022en_US
dc.identifier.cristinIDFRIDAID 2073535
dc.identifier.doi10.1186/s12913-022-08648-1
dc.identifier.issn1472-6963
dc.identifier.urihttps://hdl.handle.net/10037/27366
dc.language.isoengen_US
dc.publisherBMCen_US
dc.relation.journalBMC Health Services Research
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2022 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleInterdisciplinary collaboration across secondary and primary care to improve medication safety in the elderly (The IMMENSE study) – a randomized controlled trialen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Med mindre det står noe annet, er denne innførselens lisens beskrevet som Attribution 4.0 International (CC BY 4.0)