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dc.contributor.authorTouw, Carolina E.
dc.contributor.authorNemeth, Banne
dc.contributor.authorLijfering, Willem M.
dc.contributor.authorvan Adrichem, Raymond A.
dc.contributor.authorWilsgård, line
dc.contributor.authorLatysheva, Nadezhda
dc.contributor.authorRamberg, Cathrine
dc.contributor.authorNelissen, Rob G. H. H.
dc.contributor.authorHansen, John Bjarne
dc.contributor.authorCannegieter, Suzanne C.
dc.date.accessioned2022-11-15T08:50:27Z
dc.date.available2022-11-15T08:50:27Z
dc.date.issued2022-06-08
dc.description.abstractBackground: Lower-leg injury and knee arthroscopy are both associated with venous thromboembolism (VTE). The mechanism of VTE in both situations is unknown, including the role of procoagulant microparticles. This may provide useful information for individualizing thromboprophylactic treatment in both patient groups.<p> <p>Objective: We aimed to study the effect of (1) lower-leg trauma and (2) knee arthroscopy on procoagulant phospholipid-dependent (PPL) activity plasma levels. <p>Methods: POT-(K)CAST trial participants who did not develop VTE were randomly selected for the current study. Plasma was collected shortly after lower-leg trauma or before and after knee arthroscopy. For aim 1, samples of 67 patients with lowerleg injury were compared with control samples (preoperative samples of 74 patients undergoing arthroscopy). Linear regression was used to obtain mean ratios (natural logarithm retransformed data), adjusted for age, sex, body mass index, infections, and comorbidities. For aim 2, pre- and postoperative samples of 49 patients undergoing arthroscopy were compared using paired t tests. PPL activity was measured using modified activated factor X–dependent PPL clotting assay. <p>Results: For aim 1, PPL activity levels were almost threefold higher in patients with lower-leg injury compared with controls, that is, mean ratio, 2.82 (95% confidence interval [CI], 1.98-4.03). For aim 2, postoperative PPL activity levels did not change significantly, that is, mean change, −0.72 mU/mL (95% CI, −2.03 to 0.59). <p>Conclusion: Lower-leg trauma was associated with increased plasma levels of PPL activity, in contrast to knee arthroscopy. Lower-leg trauma triggers the release of procoagulant microparticles.en_US
dc.identifier.citationTouw, Nemeth, Lijfering, van Adrichem, Wilsgård, Latysheva, Ramberg, Nelissen, Hansen, Cannegieter. Effect of lower-leg trauma and knee arthroscopy on procoagulant phospholipid-dependent activity. Research and Practice in Thrombosis and Haemostasis. 2022;6(4)en_US
dc.identifier.cristinIDFRIDAID 2054836
dc.identifier.doi10.1002/rth2.12729
dc.identifier.issn2475-0379
dc.identifier.urihttps://hdl.handle.net/10037/27370
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.journalResearch and Practice in Thrombosis and Haemostasis
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2022 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0en_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)en_US
dc.titleEffect of lower-leg trauma and knee arthroscopy on procoagulant phospholipid-dependent activityen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
Med mindre det står noe annet, er denne innførselens lisens beskrevet som Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)