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dc.contributor.authorNonterah, Engelbert A.
dc.contributor.authorCrowther, Nigel J.
dc.contributor.authorKlipstein-Grobusch, Kerstin
dc.contributor.authorOduro, Abraham R.
dc.contributor.authorKavousi, Maryam
dc.contributor.authorAgongo, Godfred
dc.contributor.authorAnderson, Todd J.
dc.contributor.authorAsiki, Gershim
dc.contributor.authorBoua, Palwendé R.
dc.contributor.authorChoma, Solomon S. R.
dc.contributor.authorCouper, David J.
dc.contributor.authorEngström, Gunnar
dc.contributor.authorde Graaf, Jacqueline
dc.contributor.authorKauhanen, Jussi
dc.contributor.authorLonn, Eva M.
dc.contributor.authorMathiesen, Ellisiv B.
dc.contributor.authorMicklesfield, Lisa K.
dc.contributor.authorOkazaki, Shuhei
dc.contributor.authorPolak, Joseph F.
dc.contributor.authorRundek, Tatjana
dc.contributor.authorSalonen, Jukka T.
dc.contributor.authorTollman, Stephen M.
dc.contributor.authorTuomainen, Tomi-Pekka
dc.contributor.authorGrobbee, Diederick E.
dc.contributor.authorRamsay, Michéle
dc.contributor.authorBots, Michiel L.
dc.date.accessioned2022-11-17T10:16:56Z
dc.date.available2022-11-17T10:16:56Z
dc.date.issued2022-07-25
dc.description.abstractBACKGROUND: The major risk factors for atherosclerotic cardiovascular disease differ by race or ethnicity but have largely been defined using populations of European ancestry. Despite the rising prevalence of cardiovascular disease in Africa there are few related data from African populations. Therefore, we compared the association of established cardiovascular risk factors with carotid-intima media thickness (CIMT), a subclinical marker of atherosclerosis, between African, African American, Asian, European, and Hispanic populations.<p> <p>METHODS AND RESULTS: Cross-sectional analyses of 34 025 men and women drawn from 15 cohorts in Africa, Asia, Europe, and North America were undertaken. Classical cardiovascular risk factors were assessed and CIMT measured using B-mode ultrasound. Ethnic differences in the association of established cardiovascular risk factors with CIMT were determined using a 2-stage individual participant data meta-analysis with beta coefficients expressed as a percentage using the White population as the reference group. CIMT adjusted for risk factors was the greatest among African American populations followed by Asian, European, and Hispanic populations with African populations having the lowest mean CIMT. In all racial or ethnic groups, men had higher CIMT levels compared with women. Age, sex, body mass index, and systolic blood pressure had a significant positive association with CIMT in all races and ethnicities at varying magnitudes. When compared with European populations, the association of age, sex, and systolic blood pressure with CIMT was weaker in all races and ethnicities. Smoking (beta coefficient, 0.39; 95% CI, 0.09–0.70), body mass index (beta coefficient, 0.05; 95% CI, 0.01–0.08) and glucose (beta coefficient, 0.13; 95% CI, 0.06–0.19) had the strongest positive association with CIMT in the Asian population when compared with all other racial and ethnic groups. High-density lipoprotein-cholesterol had significant protective effects in African American (beta coefficient, −0.31; 95% CI, −0.42 to −0.21) and African (beta coefficient, −0.26; 95% CI, −0.31 to −0.19) populations only.en_US
dc.identifier.citationNonterah, Crowther, Klipstein-Grobusch, Oduro, Kavousi, Agongo, Anderson, Asiki, Boua, Choma, Couper, Engström, de Graaf, Kauhanen, Lonn, Mathiesen, Micklesfield, Okazaki, Polak, Rundek, Salonen, Tollman, Tuomainen, Grobbee, Ramsay, Bots. Racial and Ethnic Differences in the Association Between Classical Cardiovascular Risk Factors and Common Carotid Intima-Media Thickness: An Individual Participant Data Meta-Analysis. Journal of the American Heart Association (JAHA). 2022;11(15)en_US
dc.identifier.cristinIDFRIDAID 2063221
dc.identifier.doi10.1161/JAHA.121.023704
dc.identifier.issn2047-9980
dc.identifier.urihttps://hdl.handle.net/10037/27397
dc.language.isoengen_US
dc.publisherAmerican Heart Associationen_US
dc.relation.journalJournal of the American Heart Association (JAHA)
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2022 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0en_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)en_US
dc.titleRacial and Ethnic Differences in the Association Between Classical Cardiovascular Risk Factors and Common Carotid Intima-Media Thickness: An Individual Participant Data Meta-Analysisen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
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