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dc.contributor.authorGram, Inger Torhild
dc.contributor.authorPark, Song-Yi
dc.contributor.authorWilkens, Lynne R.
dc.contributor.authorLe Marchand, Loïc
dc.contributor.authorSetiawan, Veronica Wendy
dc.date.accessioned2022-11-21T08:32:40Z
dc.date.available2022-11-21T08:32:40Z
dc.date.issued2022-10-17
dc.description.abstractPurpose To examine whether the detrimental smoking-related association with pancreatic cancer (PC) is the same for women as for men.<p> <p>Methods We analyzed data from 192,035 participants aged 45–75 years, enrolled in the Multiethnic Cohort study (MEC) in 1993–1996. We identifed PC cases via linkage to the Hawaii and California Surveillance, Epidemiology, and End Results Program cancer registries through December 2017. <p>Results During a mean follow-up of 19.2 years, we identifed 1,936 incident PC cases. Women smokers smoked on average less than men smokers. In multivariate Cox regression models, as compared with sex-specifc never smokers, current smokers had a similar elevated risk of PC for women, hazard ratio (HR) 1.49 (95% CI 1.24, 1.79) and as for men, HR 1.48 (95% CI 1.22, 1.79) (p<sub>heterogeneity</sub>: 0.79). Former smokers showed a decrease in risk of PC for men within 5 years, HR 0.74 (95% CI 0.57, 0.97) and for women within 10 years after quitting, HR 0.70 (95% CI 0.50, 0.96), compared with their sex-specifc current smokers. Both sexes showed a consistent, strong, positive dose–response association with PC for the four measures (age at initiation, duration, number of cigarettes per day, number of pack-years) of smoking exposure among current smokers and an inverse association for years of quitting and age at smoking cessation among former smokers (all p<sub>trend</sub>’s<0.001). <p>Conclusion Although MEC women smoke on average less than their men counterparts, the smoking-related increase in PC risk and the benefts of cessation seem to be of similar magnitudes for women as for men.en_US
dc.identifier.citationGram, Park, Wilkens, Le Marchand, Setiawan. Smoking and pancreatic cancer: a sex-specific analysis in the Multiethnic Cohort study. Cancer Causes and Control. 2022en_US
dc.identifier.cristinIDFRIDAID 2065771
dc.identifier.doi10.1007/s10552-022-01637-z
dc.identifier.issn0957-5243
dc.identifier.issn1573-7225
dc.identifier.urihttps://hdl.handle.net/10037/27425
dc.language.isoengen_US
dc.publisherSpringeren_US
dc.relation.journalCancer Causes and Control
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2022 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleSmoking and pancreatic cancer: a sex-specific analysis in the Multiethnic Cohort studyen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Med mindre det står noe annet, er denne innførselens lisens beskrevet som Attribution 4.0 International (CC BY 4.0)