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dc.contributor.authorEikenes, Live
dc.contributor.authorVisser, Eelke
dc.contributor.authorVangberg, Torgil Riise
dc.contributor.authorHåberg, Asta
dc.date.accessioned2022-11-21T10:59:28Z
dc.date.available2022-11-21T10:59:28Z
dc.date.issued2022-10-03
dc.description.abstractWhether head size and/or biological sex influence proxies of white matter (WM) microstructure such as fractional anisotropy (FA) and mean diffusivity (MD) remains controversial. Diffusion tensor imaging (DTI) indices are also associated with age, but there are large discrepancies in the spatial distribution and timeline of age-related differences reported. The aim of this study was to evaluate the associations between intracranial volume (ICV), sex, and age and DTI indices from WM in a population-based study of healthy individuals (n = 812) aged 50–66 in the Nord-Trøndelag health survey. Semiautomated tractography and tract-based spatial statistics (TBSS) analyses were performed on the entire sample and in an ICV-matched sample of men and women. The tractography results showed a similar positive association between ICV and FA in all major WM tracts in men and women. Associations between ICV and MD, radial diffusivity and axial diffusivity were also found, but to a lesser extent than FA. The TBSS results showed that both men and women had areas of higher and lower FA when controlling for age, but after controlling for age and ICV only women had areas with higher FA. The ICV matched analysis also demonstrated that only women had areas of higher FA. Age was negatively associated with FA across the entire WM skeleton in the TBSS analysis, independent of both sex and ICV. Combined, these findings demonstrated that both ICV and sex contributed to variation in DTI indices and emphasized the importance of considering ICV as a covariate in DTI analysis.en_US
dc.identifier.citationEikenes, Visser, Vangberg, Håberg. Both brain size and biological sex contribute to variation in white matter microstructure in middle-aged healthy adults. Human Brain Mapping. 2022en_US
dc.identifier.cristinIDFRIDAID 2067960
dc.identifier.doi10.1002/hbm.26093
dc.identifier.issn1065-9471
dc.identifier.issn1097-0193
dc.identifier.urihttps://hdl.handle.net/10037/27437
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.journalHuman Brain Mapping
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2022 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleBoth brain size and biological sex contribute to variation in white matter microstructure in middle-aged healthy adultsen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Med mindre det står noe annet, er denne innførselens lisens beskrevet som Attribution 4.0 International (CC BY 4.0)