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dc.contributor.authorWedekind, Roland
dc.contributor.authorRothwell, Joseph A.
dc.contributor.authorViallon, Vivian
dc.contributor.authorKeski-Rahkonen, Pekka
dc.contributor.authorSchmidt, Julie A.
dc.contributor.authorChajes, Veronique
dc.contributor.authorKatzke, Vna
dc.contributor.authorJohnson, Theron
dc.contributor.authorSantucci de Magistris, Maria
dc.contributor.authorKrogh, Vittorio
dc.contributor.authorAmiano, Pilar
dc.contributor.authorSacerdote, Carlotta
dc.contributor.authorRedondo-Sánchez, Daniel
dc.contributor.authorHuerta, José María
dc.contributor.authorTjønneland, Anne
dc.contributor.authorPokharel, Pratik
dc.contributor.authorJakszyn, Paula
dc.contributor.authorTumino, Rosario
dc.contributor.authorArdanaz, Eva
dc.contributor.authorSandanger, Torkjel M
dc.contributor.authorWinkvist, Anna
dc.contributor.authorHultdin, Johan
dc.contributor.authorSchulze, Matthias B.
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorGunter, Marc J.
dc.contributor.authorHuybrechts, Inge
dc.contributor.authorScalbert, Augustin
dc.date.accessioned2022-11-22T09:46:36Z
dc.date.available2022-11-22T09:46:36Z
dc.date.issued2022-06-08
dc.description.abstractBackground & aims: Circulating levels of acylcarnitines (ACs) have been associated with the risk of various diseases such as cancer and type 2 diabetes. Diet and lifestyle factors have been shown to influence AC concentrations but a better understanding of their biological, lifestyle and metabolic determinants is needed. <p><p>Methods: Circulating ACs were measured in blood by targeted (15 ACs) and untargeted metabolomics (50 ACs) in 7770 and 395 healthy participants of the European Prospective Investigation into Cancer and Nutrition (EPIC), respectively. Associations with biological and lifestyle characteristics, dietary patterns, self-reported intake of individual foods, estimated intake of carnitine and fatty acids, and fatty acids in plasma phospholipid fraction and amino acids in blood were assessed. <p>Results: Age, sex and fasting status were associated with the largest proportion of AC variability (partial-r up to 0.19, 0.18 and 0.16, respectively). Some AC species of medium or long-chain fatty acid moiety were associated with the corresponding fatty acids in plasma (partial-r ¼ 0.24) or with intake of specific foods such as dairy foods containing the same fatty acid. ACs of short-chain fatty acid moiety (propionylcarnitine and valerylcarnitine) were moderately associated with concentrations of branched-chain amino acids (partial-r ¼ 0.5). Intake of most other foods and of carnitine showed little association with AC levels. <p>Conclusions: Our results show that determinants of ACs in blood vary according to their fatty acid moiety, and that their concentrations are related to age, sex, diet, and fasting status. Knowledge on their potential determinants may help interpret associations of ACs with disease risk and inform on potential dietary and lifestyle factors that might be modified for disease prevention.en_US
dc.identifier.citationWedekind, Rothwell, Viallon, Keski-Rahkonen, Schmidt, Chajes, Katzke, Johnson, Santucci de Magistris, Krogh, Amiano, Sacerdote, Redondo-Sánchez, Huerta, Tjønneland, Pokharel, Jakszyn, Tumino, Ardanaz, Sandanger, Winkvist, Hultdin, Schulze, Weiderpass, Gunter, Huybrechts, Scalbert. Determinants of blood acylcarnitine concentrations in healthy individuals of the European Prospective Investigation into Cancer and Nutrition. Clinical Nutrition. 2022;41(8):1735-1745en_US
dc.identifier.cristinIDFRIDAID 2055973
dc.identifier.doi10.1016/j.clnu.2022.05.020
dc.identifier.issn0261-5614
dc.identifier.issn1532-1983
dc.identifier.urihttps://hdl.handle.net/10037/27454
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalClinical Nutrition
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2022 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0en_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)en_US
dc.titleDeterminants of blood acylcarnitine concentrations in healthy individuals of the European Prospective Investigation into Cancer and Nutritionen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)