dc.contributor.author | Wedekind, Roland | |
dc.contributor.author | Rothwell, Joseph A. | |
dc.contributor.author | Viallon, Vivian | |
dc.contributor.author | Keski-Rahkonen, Pekka | |
dc.contributor.author | Schmidt, Julie A. | |
dc.contributor.author | Chajes, Veronique | |
dc.contributor.author | Katzke, Vna | |
dc.contributor.author | Johnson, Theron | |
dc.contributor.author | Santucci de Magistris, Maria | |
dc.contributor.author | Krogh, Vittorio | |
dc.contributor.author | Amiano, Pilar | |
dc.contributor.author | Sacerdote, Carlotta | |
dc.contributor.author | Redondo-Sánchez, Daniel | |
dc.contributor.author | Huerta, José María | |
dc.contributor.author | Tjønneland, Anne | |
dc.contributor.author | Pokharel, Pratik | |
dc.contributor.author | Jakszyn, Paula | |
dc.contributor.author | Tumino, Rosario | |
dc.contributor.author | Ardanaz, Eva | |
dc.contributor.author | Sandanger, Torkjel M | |
dc.contributor.author | Winkvist, Anna | |
dc.contributor.author | Hultdin, Johan | |
dc.contributor.author | Schulze, Matthias B. | |
dc.contributor.author | Weiderpass, Elisabete | |
dc.contributor.author | Gunter, Marc J. | |
dc.contributor.author | Huybrechts, Inge | |
dc.contributor.author | Scalbert, Augustin | |
dc.date.accessioned | 2022-11-22T09:46:36Z | |
dc.date.available | 2022-11-22T09:46:36Z | |
dc.date.issued | 2022-06-08 | |
dc.description.abstract | Background & aims: Circulating levels of acylcarnitines (ACs) have been associated with the risk of
various diseases such as cancer and type 2 diabetes. Diet and lifestyle factors have been shown to influence AC concentrations but a better understanding of their biological, lifestyle and metabolic determinants is needed. <p><p>Methods: Circulating ACs were measured in blood by targeted (15 ACs) and untargeted metabolomics (50
ACs) in 7770 and 395 healthy participants of the European Prospective Investigation into Cancer and
Nutrition (EPIC), respectively. Associations with biological and lifestyle characteristics, dietary patterns,
self-reported intake of individual foods, estimated intake of carnitine and fatty acids, and fatty acids in
plasma phospholipid fraction and amino acids in blood were assessed.
<p>Results: Age, sex and fasting status were associated with the largest proportion of AC variability (partial-r
up to 0.19, 0.18 and 0.16, respectively). Some AC species of medium or long-chain fatty acid moiety were
associated with the corresponding fatty acids in plasma (partial-r ¼ 0.24) or with intake of specific foods
such as dairy foods containing the same fatty acid. ACs of short-chain fatty acid moiety (propionylcarnitine and valerylcarnitine) were moderately associated with concentrations of branched-chain
amino acids (partial-r ¼ 0.5). Intake of most other foods and of carnitine showed little association
with AC levels.
<p>Conclusions: Our results show that determinants of ACs in blood vary according to their fatty acid moiety,
and that their concentrations are related to age, sex, diet, and fasting status. Knowledge on their potential
determinants may help interpret associations of ACs with disease risk and inform on potential dietary
and lifestyle factors that might be modified for disease prevention. | en_US |
dc.identifier.citation | Wedekind, Rothwell, Viallon, Keski-Rahkonen, Schmidt, Chajes, Katzke, Johnson, Santucci de Magistris, Krogh, Amiano, Sacerdote, Redondo-Sánchez, Huerta, Tjønneland, Pokharel, Jakszyn, Tumino, Ardanaz, Sandanger, Winkvist, Hultdin, Schulze, Weiderpass, Gunter, Huybrechts, Scalbert. Determinants of blood acylcarnitine concentrations in healthy individuals of the European Prospective Investigation into Cancer and Nutrition. Clinical Nutrition. 2022;41(8):1735-1745 | en_US |
dc.identifier.cristinID | FRIDAID 2055973 | |
dc.identifier.doi | 10.1016/j.clnu.2022.05.020 | |
dc.identifier.issn | 0261-5614 | |
dc.identifier.issn | 1532-1983 | |
dc.identifier.uri | https://hdl.handle.net/10037/27454 | |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier | en_US |
dc.relation.journal | Clinical Nutrition | |
dc.rights.accessRights | openAccess | en_US |
dc.rights.holder | Copyright 2022 The Author(s) | en_US |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0 | en_US |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) | en_US |
dc.title | Determinants of blood acylcarnitine concentrations in healthy individuals of the European Prospective Investigation into Cancer and Nutrition | en_US |
dc.type.version | publishedVersion | en_US |
dc.type | Journal article | en_US |
dc.type | Tidsskriftartikkel | en_US |
dc.type | Peer reviewed | en_US |