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dc.contributor.authorTanturri De Horatio, Laura
dc.contributor.authorShelmerdine, Susan C.
dc.contributor.authord’Angelo, Paola
dc.contributor.authorDi Paolo, Pier Luigi
dc.contributor.authorMagni-Manzoni, Silvia
dc.contributor.authorMalattia, Clara
dc.contributor.authorDamasio, Maria Beatrice
dc.contributor.authorTomà, Paolo
dc.contributor.authorAvenarius, Derk Frederik Matthaus
dc.contributor.authorRosendahl, Karen
dc.date.accessioned2022-11-28T11:40:43Z
dc.date.available2022-11-28T11:40:43Z
dc.date.issued2022-09-23
dc.description.abstractAbstract Background Hip involvement predicts severe disease in juvenile idiopathic arthritis (JIA) and is accurately assessed by MRI. However, a child-specifc hip MRI scoring system has not been validated.<p> <p>Objective To test the intra- and interobserver agreement of several MRI markers for active and chronic hip changes in children and young adults with JIA and to examine the precision of measurements commonly used for the assessment of growth abnormalities. <p>Materials and methods Hip MRIs from 60 consecutive children, adolescents and young adults with JIA were scored independently by two sets of radiologists. One set scored the same MRIs twice. Features of active and chronic changes, growth abnormalities and secondary post-infammatory changes were scored. We used kappa statistics to analyze inter- and intraobserver agreement for categorical variables and a Bland–Altman approach to test the precision of continuous variables. <p>Results Among active changes, there was good intra- and interobserver agreement for grading overall infammation (kappa 0.6–0.7). Synovial enhancement showed a good intraobserver agreement (kappa 0.7–0.8), while the interobserver agreement was moderate (kappa 0.4–0.5). Regarding acetabular erosions on a 0–3 scale, the intraobserver agreement was 0.6 for the right hip and 0.7 for the left hip, while the interobserver agreement was 0.6 for both hips. Measurements of joint space width, caput–collum–diaphyseal angle, femoral neck–head length, femoral width and trochanteric distance were imprecise. <p>Conclusion We identifed a set of MRI markers for active and chronic changes in JIA and suggest that the more robust markers be included in future studies addressing clinical validity and long-term patient outcomes.en_US
dc.identifier.citationTanturri De Horatio, Shelmerdine, d’Angelo, Di Paolo, Magni-Manzoni, Malattia, Damasio, Tomà, Avenarius, Rosendahl. A novel magnetic resonance imaging scoring system for active and chronic changes in children and adolescents with juvenile idiopathic arthritis of the hip. Pediatric Radiology. 2022en_US
dc.identifier.cristinIDFRIDAID 2060745
dc.identifier.doi10.1007/s00247-022-05502-8
dc.identifier.issn0301-0449
dc.identifier.issn1432-1998
dc.identifier.urihttps://hdl.handle.net/10037/27564
dc.language.isoengen_US
dc.publisherSpringeren_US
dc.relation.journalPediatric Radiology
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2022 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleA novel magnetic resonance imaging scoring system for active and chronic changes in children and adolescents with juvenile idiopathic arthritis of the hipen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's license is described as Attribution 4.0 International (CC BY 4.0)