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dc.contributor.authorChoi, Tae-Young
dc.contributor.authorAng, Lin
dc.contributor.authorJun, Ji Hee
dc.contributor.authorAlræk, Terje
dc.contributor.authorBirch, Stephen
dc.contributor.authorLu, Weidong
dc.contributor.authorLee, Myeong Soo
dc.date.accessioned2022-12-02T10:16:53Z
dc.date.available2022-12-02T10:16:53Z
dc.date.issued2022-09-11
dc.description.abstractBreast cancer (BC) is the most common cancer in women and is a serious threat to women’s health. Cancer-related fatigue (CRF) is a distressing symptom in BC patients during and after chemotherapy or radiation therapy that severely affects quality of life (QoL). AT is widely used for fatigue management. However, the effect of AT on CRF is still uncertain. This study aimed to evaluate the efficacy and safety of AT in the management of CRF in patients with BC. Eleven databases were searched through June 2022. Two researchers independently performed the database search, study selection, data extraction, and risk of bias assessment. Study selection was performed based on predefined Participants, Intervention, Comparators, Outcomes, Study design (PICOS) criteria, and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed when reporting the results. A meta-analysis was performed according to the Cochrane systematic review method using RevMan 5.3. A total of 12 studies including a total of 1084 participants were included. The results showed that AT had a beneficial effect compared with sham AT (n = 256, SMD = −0.26, 95% CI [−0.51, −0.01], p = 0.04, I<sup>2</sup> = 0%) and a long-term effect on fatigue score (n = 209, MD = −0.32, 95% CI [–0.59, −0.04], p = 0.02, I<sup>2</sup> = 0%). Meta-analysis showed that AT had a beneficial effect compared with usual care (UC) on fatigue scores (n = 238, SMD = −0.39, 95% CI [−0.66 to −0.12], p = 0.005, I<sup>2</sup> = 0%). Of the 12 articles, 3 articles were judged as having a low risk of bias in all domains and hence were of high quality. No serious adverse effects were identified. AT is an effective and safe treatment for CRF, and AT is more effective than sham AT or UC or wait-list control (WLC). Nevertheless, the methodological quality of most of these studies was low, and the included studies/sample sizes were small, so the ability to derive decisive implications was limited. Further research is needed to confirm these findings.en_US
dc.identifier.citationChoi, Ang, Jun, Alræk, Birch, Lu, Lee. Acupuncture for managing cancer-related fatigue in breast cancer patients: A systematic review and meta-analysis. Cancers. 2022;14(18):1-14en_US
dc.identifier.cristinIDFRIDAID 2061130
dc.identifier.doi10.3390/cancers14184419
dc.identifier.issn2072-6694
dc.identifier.urihttps://hdl.handle.net/10037/27665
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.relation.journalCancers
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2022 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleAcupuncture for managing cancer-related fatigue in breast cancer patients: A systematic review and meta-analysisen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's license is described as Attribution 4.0 International (CC BY 4.0)