Browsing Doktorgradsavhandlinger (NT-fak) by Author "Sivertsen, Annfrid"
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Development of novel renin inhibitors and interaction of antimicrobial and cytotoxic peptides with plasma proteins. A drug discovery study
Sivertsen, Annfrid (Doctoral thesis; Doktorgradsavhandling, 2013-06-14)In this study we have explored the structure activity relationship of molecules with potential as novel drug classes toward current medical challenges as hypertension, cancer and infections caused by antibiotic resistant bacteria. Direct renin inhibitors have for a long time been an interesting group of potential anti-hypertension drugs, as they inhibit the first and rate-limiting step in the signal ...