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dc.contributor.authorHo, Kevin Kwan Ngai
dc.contributor.authorSkarpsno, Eivind S.
dc.contributor.authorNilsen, Kristian Bernhard
dc.contributor.authorFerreira, Paulo Herrique
dc.contributor.authorPinheiro, Marina
dc.contributor.authorHopstock, Laila Arnesdatter
dc.contributor.authorJohnsen, Marianne Bakke
dc.contributor.authorSteingrímsdóttir, Ólöf Anna
dc.contributor.authorNielsen, Christopher Sivert
dc.contributor.authorStubhaug, Audun
dc.contributor.authorSimic, Milena
dc.date.accessioned2023-04-04T13:17:46Z
dc.date.available2023-04-04T13:17:46Z
dc.date.issued2022-04-14
dc.description.abstractObjectives - To examine the possible bidirectional association between insomnia and comorbid chronic low back pain (LBP) and lower limb pain and to explore whether high-sensitivity C-reactive protein (hsCRP) amplifies these associations.<p> <p>Methods - We calculated adjusted risk ratios (RR) with 95% confidence intervals (CI) for the development of insomnia and mild-to-severe chronic LBP and lower limb pain at 11 years follow-up in participants aged ≥32 years and with hsCRP ≤10 mg/L at baseline in 2007–2008: 3,714 without chronic LBP or lower limb pain (sample 1) and 7,892 without insomnia (sample 2).<p> <p>Results - Compared to participants without chronic pain, participants with comorbid chronic LBP and lower limb pain had a RR of insomnia of 1.37 (95% CI 1.12–1.66). Compared with participants without insomnia, participants with insomnia did not have an increased risk of comorbid chronic LBP and lower limb pain (RR: 1.06, 95% CI 0.76–1.46); however, participants with insomnia had a RR of chronic LBP of 1.20 (95% CI 1.02–1.42). There was no strong amplifying effect of elevated hsCRP (3.00–10.0 mg/L) on these associations.<p> <p>Conclusions - These findings suggest that elevated hsCRP does not amplify the associations between insomnia and mild-to-severe chronic LBP and lower limb pain. Further research using data on the temporal relation between insomnia, chronic pain, and inflammatory responses are required to fully understand the causal pathways.en_US
dc.identifier.citationHo KKN, Skarpsno ES, Nilsen KB, Ferreira PH, Pinheiro M, Hopstock LA, Johnsen MB, Steingrímsdóttir OA, Nielsen CS, Stubhaug A, Simic M. A bidirectional study of the association between insomnia, high-sensitivity C-reactive protein, and comorbid low back pain and lower limb pain. Scandinavian Journal of Pain. 2022;23(1):110-125en_US
dc.identifier.cristinIDFRIDAID 2017304
dc.identifier.doi10.1515/sjpain-2021-0197
dc.identifier.issn1877-8860
dc.identifier.issn1877-8879
dc.identifier.urihttps://hdl.handle.net/10037/28922
dc.language.isoengen_US
dc.publisherDe Gruyteren_US
dc.relation.journalScandinavian Journal of Pain
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2022 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleA bidirectional study of the association between insomnia, high-sensitivity C-reactive protein, and comorbid low back pain and lower limb painen_US
dc.type.versionacceptedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Med mindre det står noe annet, er denne innførselens lisens beskrevet som Attribution 4.0 International (CC BY 4.0)