dc.contributor.author | Cacic, Ana | |
dc.contributor.author | Amidžic Klaric, Daniela | |
dc.contributor.author | Keser, Sabina | |
dc.contributor.author | Radikovic, Maja | |
dc.contributor.author | Rukavina, Zora | |
dc.contributor.author | Jøraholmen, May Wenche | |
dc.contributor.author | Uzelac, Lidija | |
dc.contributor.author | Kralj, Marijeta | |
dc.contributor.author | Skalko-Basnet, Natasa | |
dc.contributor.author | Segvic Klaric, Maja | |
dc.contributor.author | Vanic, Zeljka | |
dc.date.accessioned | 2023-05-02T05:28:41Z | |
dc.date.available | 2023-05-02T05:28:41Z | |
dc.date.issued | 2023-04-28 | |
dc.description.abstract | Biocompatible mucoadhesive formulations that enable a sustained drug delivery at the site
of action, while exhibiting inherent antimicrobial activity, are of great importance for improved local
therapy of vaginal infections. The aim of this research was to prepare and evaluate the potential of the
several types of azithromycin (AZM)-liposomes (180–250 nm) incorporated into chitosan hydrogel
(AZM-liposomal hydrogels) for the treatment of aerobic vaginitis. AZM-liposomal hydrogels were
characterized for in vitro release, and rheological, texture, and mucoadhesive properties under conditions simulating the vaginal site of application. The role of chitosan as a hydrogel-forming polymer
with intrinsic antimicrobial properties was explored against several bacterial strains typical for aerobic
vaginitis as well as its potential effect on the anti-staphylococcal activity of AZM-liposomes. Chitosan
hydrogel prolonged the release of the liposomal drug and exhibited inherent antimicrobial activity.
Additionally, it boosted the antibacterial effect of all tested AZM-liposomes. All AZM-liposomal
hydrogels were biocompatible with the HeLa cells and demonstrated mechanical properties suitable
for vaginal application, thus confirming their potential for enhanced local therapy of aerobic vaginitis. | en_US |
dc.identifier.citation | Cacic, Amidžic Klaric, Keser, Radikovic, Rukavina, Jøraholmen, Uzelac, Kralj, Skalko-Basnet, Segvic Klaric, Vanic. A Novel Approach for the Treatment of Aerobic Vaginitis: Azithromycin Liposomes-in-Chitosan Hydrogel. Pharmaceutics. 2023;15 | en_US |
dc.identifier.cristinID | FRIDAID 2144187 | |
dc.identifier.doi | 10.3390/pharmaceutics15051356 | |
dc.identifier.issn | 1999-4923 | |
dc.identifier.uri | https://hdl.handle.net/10037/29090 | |
dc.language.iso | eng | en_US |
dc.publisher | MDPI | en_US |
dc.relation.journal | Pharmaceutics | |
dc.rights.accessRights | openAccess | en_US |
dc.rights.holder | Copyright 2023 The Author(s) | en_US |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | en_US |
dc.rights | Attribution 4.0 International (CC BY 4.0) | en_US |
dc.title | A Novel Approach for the Treatment of Aerobic Vaginitis: Azithromycin Liposomes-in-Chitosan Hydrogel | en_US |
dc.type.version | publishedVersion | en_US |
dc.type | Journal article | en_US |
dc.type | Tidsskriftartikkel | en_US |
dc.type | Peer reviewed | en_US |