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dc.contributor.authorCacic, Ana
dc.contributor.authorAmidžic Klaric, Daniela
dc.contributor.authorKeser, Sabina
dc.contributor.authorRadikovic, Maja
dc.contributor.authorRukavina, Zora
dc.contributor.authorJøraholmen, May Wenche
dc.contributor.authorUzelac, Lidija
dc.contributor.authorKralj, Marijeta
dc.contributor.authorSkalko-Basnet, Natasa
dc.contributor.authorSegvic Klaric, Maja
dc.contributor.authorVanic, Zeljka
dc.date.accessioned2023-05-02T05:28:41Z
dc.date.available2023-05-02T05:28:41Z
dc.date.issued2023-04-28
dc.description.abstractBiocompatible mucoadhesive formulations that enable a sustained drug delivery at the site of action, while exhibiting inherent antimicrobial activity, are of great importance for improved local therapy of vaginal infections. The aim of this research was to prepare and evaluate the potential of the several types of azithromycin (AZM)-liposomes (180–250 nm) incorporated into chitosan hydrogel (AZM-liposomal hydrogels) for the treatment of aerobic vaginitis. AZM-liposomal hydrogels were characterized for in vitro release, and rheological, texture, and mucoadhesive properties under conditions simulating the vaginal site of application. The role of chitosan as a hydrogel-forming polymer with intrinsic antimicrobial properties was explored against several bacterial strains typical for aerobic vaginitis as well as its potential effect on the anti-staphylococcal activity of AZM-liposomes. Chitosan hydrogel prolonged the release of the liposomal drug and exhibited inherent antimicrobial activity. Additionally, it boosted the antibacterial effect of all tested AZM-liposomes. All AZM-liposomal hydrogels were biocompatible with the HeLa cells and demonstrated mechanical properties suitable for vaginal application, thus confirming their potential for enhanced local therapy of aerobic vaginitis.en_US
dc.identifier.citationCacic, Amidžic Klaric, Keser, Radikovic, Rukavina, Jøraholmen, Uzelac, Kralj, Skalko-Basnet, Segvic Klaric, Vanic. A Novel Approach for the Treatment of Aerobic Vaginitis: Azithromycin Liposomes-in-Chitosan Hydrogel. Pharmaceutics. 2023;15en_US
dc.identifier.cristinIDFRIDAID 2144187
dc.identifier.doi10.3390/pharmaceutics15051356
dc.identifier.issn1999-4923
dc.identifier.urihttps://hdl.handle.net/10037/29090
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.relation.journalPharmaceutics
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleA Novel Approach for the Treatment of Aerobic Vaginitis: Azithromycin Liposomes-in-Chitosan Hydrogelen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Med mindre det står noe annet, er denne innførselens lisens beskrevet som Attribution 4.0 International (CC BY 4.0)