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dc.contributor.authorThorvaldsen, Steinar
dc.contributor.authorHössjer, Ola
dc.date.accessioned2023-08-08T10:30:54Z
dc.date.available2023-08-08T10:30:54Z
dc.date.issued2023-07-25
dc.description.abstractA prominent problem in analysing genetic information has been a lack of mathematical frameworks for doing so. This article offers some new statistical methods to model and analyse information content in proteins, protein families, and their sequences. We discuss how to understand the qualitative aspects of genetic information, how to estimate the quantitative aspects of it, and implement a statistical model where the qualitative genetic function is represented jointly with its probabilistic metric of self-information. The functional information of protein families in the Cath and Pfam databases are estimated using a method inspired by rejection sampling. Scientific work may place these components of information as one of the fundamental aspects of molecular biology.en_US
dc.identifier.citationThorvaldsen, Hössjer. Estimating the information content of genetic sequence data. The Journal of the Royal Statistical Society, Series C (Applied Statistics). 2023en_US
dc.identifier.cristinIDFRIDAID 2164175
dc.identifier.doi10.1093/jrsssc/qlad062
dc.identifier.issn0035-9254
dc.identifier.issn1467-9876
dc.identifier.urihttps://hdl.handle.net/10037/29774
dc.language.isoengen_US
dc.publisherOxford University Pressen_US
dc.relation.journalThe Journal of the Royal Statistical Society, Series C (Applied Statistics)
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleEstimating the information content of genetic sequence dataen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's license is described as Attribution 4.0 International (CC BY 4.0)