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dc.contributor.authorLarsen, Marthe
dc.contributor.authorLynge, Elsebeth
dc.contributor.authorLee, Christoph I.
dc.contributor.authorLång, Kristina
dc.contributor.authorHofvind, Solveig Sand-Hanssen
dc.date.accessioned2023-08-11T08:44:53Z
dc.date.available2023-08-11T08:44:53Z
dc.date.issued2023-03-21
dc.description.abstractPurpose: The European Society on Breast Imaging has recommended supplemental magnetic resonance imaging (MRI) every two to four years for women with mammographically dense breasts. This may not be feasible in many screening programs. Also, the European Commission Initiative on Breast Cancer suggests not implementing screening with MRI. By analyzing interval cancers and time from screening to diagnosis by density, we present alternative screening strategies for women with dense breasts.<p> <p>Methods: Our BreastScreen Norway cohort included 508 536 screening examinations, including 3125 screendetected and 945 interval breast cancers. Time from screening to interval cancer was stratified by density measured by an automated software and classified into Volpara Density Grades (VDGs) 1–4. Examinations with volumetric density ≤3.4% were categorized as VDG1, 3.5%–7.4% as VDG2, 7.5%–15.4% as VDG3, and ≥15.5% as VDG4. Interval cancer rates were also determined by continuous density measures. <p>Results: Median time from screening to interval cancer was 496 (IQR: 391–587) days for VDG1, 500 (IQR: 350–616) for VDG2, 482 (IQR: 309–595) for VDG3 and 427 (IQR: 266–577) for VDG4. A total of 35.9% of the interval cancers among VDG4 were detected within the first year of the biennial screening interval. For VDG2, 26.3% were detected within the first year. The highest annual interval cancer rate (2.7 per 1000 examinations) was observed for VDG4 in the second year of the biennial interval. <p>Conclusions: Annual screening of women with extremely dense breasts may reduce the interval cancer rate and increase program-wide sensitivity, especially in settings where supplemental MRI screening is not feasible.en_US
dc.identifier.citationLarsen, Lynge, Lee, Lång, Hofvind. Mammographic density and interval cancers in mammographic screening: Moving towards more personalized screening. Breast. 2023;69:306-311en_US
dc.identifier.cristinIDFRIDAID 2141923
dc.identifier.doi10.1016/j.breast.2023.03.010
dc.identifier.issn0960-9776
dc.identifier.issn1532-3080
dc.identifier.urihttps://hdl.handle.net/10037/29867
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalBreast
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleMammographic density and interval cancers in mammographic screening: Moving towards more personalized screeningen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's license is described as Attribution 4.0 International (CC BY 4.0)