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dc.contributor.authorYammine, S.G.
dc.contributor.authorHuybrechts, I.
dc.contributor.authorBiessy, C.
dc.contributor.authorDossus, L.
dc.contributor.authorPanico, S.
dc.contributor.authorSánchez, M.J.
dc.contributor.authorBenetou, V.
dc.contributor.authorTurzanski-Fortner, R.
dc.contributor.authorKatzke, V.
dc.contributor.authorIdahl, A.
dc.contributor.authorSkeie, Guri
dc.contributor.authorOlsen, Karina Standahl
dc.contributor.authorTjønneland, A.
dc.contributor.authorHalkjaer, J.
dc.contributor.authorColorado-Yohar, S.
dc.contributor.authorHeath, A.K.
dc.contributor.authorSonestedt, E.
dc.contributor.authorSartor, H.
dc.contributor.authorSchulze, M.B.
dc.contributor.authorPalli, D.
dc.contributor.authorCrous-Bou, M.
dc.contributor.authorDorronsoro, A.
dc.contributor.authorOvervad, K.
dc.contributor.authorGurrea, A. Barricarte
dc.contributor.authorSeveri, G.
dc.contributor.authorVermeulen, R.C.H.
dc.contributor.authorSandanger, Torkjel M
dc.contributor.authorTravis, R.C.
dc.contributor.authorKey, T.
dc.contributor.authorAmiano, P.
dc.contributor.authorVan Guelpen, Guelpen
dc.contributor.authorJohansson, Mattias
dc.contributor.authorSund, M.
dc.contributor.authorTumino, R.
dc.contributor.authorWareham, N.
dc.contributor.authorSacerdote, C.
dc.contributor.authorKrogh, V.
dc.contributor.authorBrennan, P.
dc.contributor.authorRiboli, E.
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorGunter, M.J.
dc.contributor.authorChajès, V.
dc.date.accessioned2023-08-14T11:43:51Z
dc.date.available2023-08-14T11:43:51Z
dc.date.issued2023-02-16
dc.description.abstractBackground - Diet may impact important risk factors for endometrial cancer such as obesity and inflammation. However, evidence on the role of specific dietary factors is limited. We investigated associations between dietary fatty acids and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC).<p> <p>Methods - This analysis includes 1,886 incident endometrial cancer cases and 297,432 non-cases. All participants were followed up for a mean of 8.8 years. Multivariable Cox proportional hazard models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI) of endometrial cancer across quintiles of individual fatty acids estimated from various food sources quantified through food frequency questionnaires in the entire EPIC cohort. The false discovery rate (q-values) was computed to control for multiple comparisons.<p> <p>Results - Consumption of n-6 γ-linolenic acid was inversely associated with endometrial cancer risk (HR comparing 5th with 1st quintileQ5−Q1=0.77, 95% CI = 0.64; 0.92, ptrend=0.01, q-value = 0.15). This association was mainly driven by γ-linolenic acid derived from plant sources (HRper unit increment=0.94, 95%CI= (0.90;0.98), p = 0.01) but not from animal sources (HRper unit increment= 1.00, 95%CI = (0.92; 1.07), p = 0.92). In addition, an inverse association was found between consumption of n-3 α-linolenic acid from vegetable sources and endometrial cancer risk (HRper unit increment= 0.93, 95%CI = (0.87; 0.99), p = 0.04). No significant association was found between any other fatty acids (individual or grouped) and endometrial cancer risk.<p> <p>Conclusion - Our results suggest that higher consumption of γ-linolenic acid and α-linoleic acid from plant sources may be associated with lower risk of endometrial cancer.en_US
dc.identifier.citationYammine, Huybrechts, Biessy, Dossus, Panico, Sánchez, Benetou, Turzanski-Fortner, Katzke, Idahl, Skeie, Olsen, Tjønneland, Halkjaer, Colorado-Yohar, Heath, Sonestedt, Sartor, Schulze, Palli, Crous-Bou, Dorronsoro, Overvad, Gurrea, Severi, Vermeulen, Sandanger, Travis, Key, Amiano, Van Guelpen, Johansson, Sund, Tumino, Wareham, Sacerdote, Krogh, Brennan, Riboli, Weiderpass, Gunter, Chajès. Dietary fatty acids and endometrial cancer risk within the European Prospective Investigation into Cancer and Nutrition. BMC Cancer. 2023;23(1)en_US
dc.identifier.cristinIDFRIDAID 2152702
dc.identifier.doi10.1186/s12885-023-10611-0
dc.identifier.issn1471-2407
dc.identifier.urihttps://hdl.handle.net/10037/29904
dc.language.isoengen_US
dc.publisherSpringer Natureen_US
dc.relation.journalBMC Cancer
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleDietary fatty acids and endometrial cancer risk within the European Prospective Investigation into Cancer and Nutritionen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Med mindre det står noe annet, er denne innførselens lisens beskrevet som Attribution 4.0 International (CC BY 4.0)