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dc.contributor.authorWalker, Rob F.
dc.contributor.authorZakai, Neil A.
dc.contributor.authorMason, Susan M.
dc.contributor.authorMacLehose, Richard F.
dc.contributor.authorNorby, Faye L.
dc.contributor.authorEvensen, Line Holtet
dc.contributor.authorAlonso, Alvaro
dc.contributor.authorLutsey, Pamela L.
dc.date.accessioned2023-08-15T08:57:06Z
dc.date.available2023-08-15T08:57:06Z
dc.date.issued2023-02-23
dc.description.abstractBackground - The risk of pregnancy-related mortality in the United States has nearly doubled since 1990, with venous thromboembolism (VTE) accounting for approximately 10% of these deaths.<p> <p>Objectives - The objective of this study was to assess whether preexisting autoimmune disease is a risk factor for postpartum VTE.<p> <p>Methods - Using the MarketScan Commercial and Medicare Supplemental administrative databases, a retrospective cohort study analyzed whether postpartum persons with autoimmune disease had a higher risk of postpartum VTE incidence than postpartum persons without autoimmune disease. Using International Classification of Diseases codes, we identified 757,303 individuals of childbearing age who had a valid delivery date with at least 12 weeks of follow-up.<p> <p>Results - Individuals were, on average, 30.7 years old (SD, 5.4), and 3.7% (N = 27,997 of 757,303) of them had evidence of preexisting autoimmune disease. In covariate-adjusted models, postpartum persons with preexisting autoimmune disease had higher rates of postpartum VTE than postpartum persons without autoimmune disease (hazard ratio [HR], 1.33; 95% CI, 1.07-1.64). When analyzed by individual autoimmune disease, those with systemic lupus erythematosus (HR, 2.49; 95% CI, 1.47-4.21) and Crohn’s disease (HR, 2.49; 95% CI, 1.34-4.64) were at an elevated risk of postpartum VTE compared with those without autoimmune disease.<p> <p>Conclusion - Autoimmune disease was associated with a higher rate of postpartum VTE, with evidence that the association was most pronounced among individuals with systemic lupus erythematosus and Crohn’s disease. These findings suggest that postpartum persons of childbearing age with autoimmune disease may require more monitoring and prophylactic care after delivery to prevent potentially fatal VTE events.en_US
dc.identifier.citationWalker, Zakai, Mason, MacLehose, Norby, Evensen, Alonso, Lutsey. Autoimmune disease and risk of postpartum venous thromboembolism. Research and Practice in Thrombosis and Haemostasis (RPTH). 2023;7(2)en_US
dc.identifier.cristinIDFRIDAID 2159377
dc.identifier.doi10.1016/j.rpth.2023.100091
dc.identifier.issn2475-0379
dc.identifier.urihttps://hdl.handle.net/10037/29942
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalResearch and Practice in Thrombosis and Haemostasis (RPTH)
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleAutoimmune disease and risk of postpartum venous thromboembolismen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Med mindre det står noe annet, er denne innførselens lisens beskrevet som Attribution 4.0 International (CC BY 4.0)