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dc.contributor.authorBøgwald, Isak
dc.contributor.authorØstbye, Tone‑Kari K
dc.contributor.authorPedersen, Alice Marie
dc.contributor.authorRønning, Sissel Beate
dc.contributor.authorDias, Jorge
dc.contributor.authorEilertsen, Karl-Erik
dc.contributor.authorWubshet, Sileshi Gizachew
dc.date.accessioned2023-08-16T08:55:15Z
dc.date.available2023-08-16T08:55:15Z
dc.date.issued2023-07-29
dc.description.abstractThe world will be dependent on the development of novel feed ingredients from renewable sources to ensure sustainable growth of the aquaculture industry. Zooplankton like Calanus finmarchicus are viable new raw material candidates, as they have optimal nutrient profiles for aquatic animals and may be sustainably harvested in large volumes. In this study, the aim was to investigate if a protein hydrolysate of C. finmarchicus was able to influence the growth performance of fish. The effect of dietary inclusion of hydrolysates was tested in a feeding trial with European sea bass (Dicentrarchus labrax) juveniles, benchmarking calanus hydrolysate (CH) against commercially available hydrolysates. The diet with CH inclusion yielded increased growth, with significantly higher body weight than hydrolysates of sardine and tuna fish at the end of the trial. The observed growth-promoting effects were further examined using an in vitro model with skeletal muscle cells from Atlantic salmon. Through bioactivity experiments with muscle cells grown in media containing CH, low-molecular fractions were found to have the greatest positive effect on proliferation, viability, and expression of muscle-specific genes. Characterization of the most potent fraction revealed an abundance of small peptides, along with amino acids and marine metabolites associated with increased muscle growth.en_US
dc.identifier.citationBøgwald I, Østbye, Pedersen AM, Rønning SB, Dias J, Eilertsen KE, Wubshet SG. Calanus finmarchicus hydrolysate improves growth performance in feeding trial with European sea bass juveniles and increases skeletal muscle growth in cell studies. Scientific Reports. 2023:1-14en_US
dc.identifier.cristinIDFRIDAID 2166796
dc.identifier.doihttps://doi.org/10.1038/s41598-023-38970-5
dc.identifier.issn2045-2322
dc.identifier.urihttps://hdl.handle.net/10037/29964
dc.language.isoengen_US
dc.publisherSpringer Natureen_US
dc.relation.journalScientific Reports
dc.relation.projectIDNofima AS: 13128en_US
dc.relation.projectIDNorges forskningsråd: 312136en_US
dc.relation.projectIDNofima AS: 13411en_US
dc.relation.projectIDNorges forskningsråd: 320086en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleCalanus finmarchicus hydrolysate improves growth performance in feeding trial with European sea bass juveniles and increases skeletal muscle growth in cell studiesen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Med mindre det står noe annet, er denne innførselens lisens beskrevet som Attribution 4.0 International (CC BY 4.0)