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dc.contributor.authorZadig, Pia Karin Karlsen
dc.contributor.authorvon Brandis, Elisabeth
dc.contributor.authorMüller, Lil-Sofie Ording
dc.contributor.authorTanturri De Horatio, Laura
dc.contributor.authorRosendahl, Karen
dc.contributor.authorAvenarius, Derk Frederik Matthaus
dc.date.accessioned2023-08-17T08:57:31Z
dc.date.available2023-08-17T08:57:31Z
dc.date.issued2023-01-26
dc.description.abstractObjectives To compare short time inversion recovery (STIR) and T2 Dixon in the detection and grading of high signal intensity areas in bone marrow on whole-body MRI in healthy children. <p><p>Methods Prospective study, including whole-body 1.5-T MRIs from 77 healthy children. Two experienced radiologists in consensus identifed and graded areas of high bone marrow signal on STIR and T2-weighted (T2W) turbo spin echo (TSE) Dixon images (presence, extension) in two diferent sessions at an interval of at least 3 weeks. In a third session, a third observer joined the two readers for an additional consensus reading with all sequences available (substitute gold standard). <p>Results Four hundred ninety of 545 (89.9%) high signal areas were visible on both sequences, while 27 (5.0%) were visible on STIR only and 28 (5.1%) on T2W Dixon only. Twenty-four of 27 (89%) lesions seen on STIR only, and 25/28 (89%) seen on T2W Dixon only, were graded as mildly increased signal intensity. The proportion of true positive high signal lesions was higher for the T2W Dixon images as compared to STIR (74.2% vs. 68.2%) (p=0.029), while the proportion of false negatives was lower (25.9% vs. 31.7% (p=0.035) for T2W Dixon and STIR, respectively). There was a moderate agreement between the T2W Dixon and STIR-based extension scores on a 0–4 scale, with a kappa of 0.45 (95% CI=0.34–0.56). <p>Conclusions Most high signal bone marrow changes identifed on a 1.5-T whole-body MRI were seen on both STIR and water-only T2W Dixon, underscoring the importance of using identical protocols when following bone-marrow signal changes over time.en_US
dc.identifier.citationZadig, von Brandis, Müller, Tanturri De Horatio, Rosendahl, Avenarius. Pediatric whole-body magnetic resonance imaging: comparison of STIR and T2 Dixon sequences in the detection and grading of high signal bone marrow changes. European Radiology. 2023en_US
dc.identifier.cristinIDFRIDAID 2143729
dc.identifier.doi10.1007/s00330-023-09413-6
dc.identifier.issn0938-7994
dc.identifier.issn1432-1084
dc.identifier.urihttps://hdl.handle.net/10037/30029
dc.language.isoengen_US
dc.publisherSpringer Natureen_US
dc.relation.journalEuropean Radiology
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titlePediatric whole-body magnetic resonance imaging: comparison of STIR and T2 Dixon sequences in the detection and grading of high signal bone marrow changesen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Med mindre det står noe annet, er denne innførselens lisens beskrevet som Attribution 4.0 International (CC BY 4.0)