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dc.contributor.authorBramness, Jørgen Gustav
dc.contributor.authorSkulberg, Knut Ragnvald
dc.contributor.authorSkulberg, Andreas
dc.contributor.authorMoe, Jenny Skumsnes
dc.contributor.authorMørland, Jørg Gustav
dc.date.accessioned2023-08-24T07:57:59Z
dc.date.available2023-08-24T07:57:59Z
dc.date.issued2023-01-28
dc.description.abstractAims - A high number of alcohol units required to feel a subjective effect of alcohol predicts future alcohol use disorders (AUDs). The subjective response to alcohol can be measured using the validated retrospective self-rated effects of alcohol (SRE) questionnaire. Few studies have investigated the specific relationship between SRE and blood alcohol concentration (BAC) in an experimental setting.<p> <p>Methods - Twenty healthy young adult male volunteers who had experience with binge drinking, but did not have AUD, filled out the SRE-questionnaire and were served with a fixed amount of alcohol per body weight. BACs were measured throughout a 12-hour period, reaching a maximum BAC of ~0.13%. Median split of SRE-scores was utilized to compare BACs among participants with relatively high effects (low SRE) and relatively low effects (high SRE) of alcohol.<p> <p>Results - Participants reporting a relatively low SRE-score had a statistically significant higher measured BAC at all time points until alcohol was eliminated. This was especially pronounced during the first 2 hours after alcohol (P = 0.015) without a significant difference in the alcohol elimination rate being detected.<p> <p>Conclusion - The study indicates that a self-ated SRE-score is related to BACs after the ingestion of a standardized amount of alcohol per body weight. Reporting a higher number of alcohol units before feeling an effect was related to a lower BAC. As the differences in BAC between relatively high and low self-rated effects appeared rapidly after intake, this could be interpreted as an effect of presystemic metabolism of alcohol.en_US
dc.identifier.citationBramness, Skulberg, Skulberg, Moe, Mørland. The Self-Rated Effects of Alcohol Are Related to Presystemic Metabolism of Alcohol. Alcohol and Alcoholism. 2023;58(2):203-208en_US
dc.identifier.cristinIDFRIDAID 2140549
dc.identifier.doi10.1093/alcalc/agad002
dc.identifier.issn0735-0414
dc.identifier.issn1464-3502
dc.identifier.urihttps://hdl.handle.net/10037/30290
dc.language.isoengen_US
dc.publisherOxford University Pressen_US
dc.relation.journalAlcohol and Alcoholism
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0en_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)en_US
dc.titleThe Self-Rated Effects of Alcohol Are Related to Presystemic Metabolism of Alcoholen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
Med mindre det står noe annet, er denne innførselens lisens beskrevet som Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)