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dc.contributor.authorHongo, Jorge Augusto
dc.contributor.authorde Castro, Giovanni Marques
dc.contributor.authorAlbuquerque Menezes, Alison Pelri
dc.contributor.authorRios Picorelli, Agnello César
dc.contributor.authorMartins da Silva, Thieres Tayroni
dc.contributor.authorImada, Eddie Luidy
dc.contributor.authorMarchionni, Luigi
dc.contributor.authorDel-Bem, Luiz-Eduardo
dc.contributor.authorVieira Chaves, Anderson
dc.contributor.authorde Freitas Almeida, Gabriel Magno
dc.contributor.authorCampelo, Felipe
dc.contributor.authorLobo, Francisco Pereira
dc.date.accessioned2023-08-25T08:19:13Z
dc.date.available2023-08-25T08:19:13Z
dc.date.issued2023-06-09
dc.description.abstractLiving species vary significantly in phenotype and genomic content. Sophisticated statistical methods linking genes with phenotypes within a species have led to breakthroughs in complex genetic diseases and genetic breeding. Despite the abundance of genomic and phenotypic data available for thousands of species, finding genotype-phenotype associations across species is challenging due to the non-independence of species data resulting from common ancestry. To address this, we present CALANGO (comparative analysis with annotation-based genomic components), a phylogeny-aware comparative genomics tool to find homologous regions and biological roles associated with quantitative phenotypes across species. In two case studies, CALANGO identified both known and previously unidentified genotype-phenotype associations. The first study revealed unknown aspects of the ecological interaction between Escherichia coli, its integrated bacteriophages, and the pathogenicity phenotype. The second identified an association between maximum height in angiosperms and the expansion of a reproductive mechanism that prevents inbreeding and increases genetic diversity, with implications for conservation biology and agriculture.en_US
dc.identifier.citationHongo, de Castro, Albuquerque Menezes, Rios Picorelli, Martins da Silva, Imada, Marchionni, Del-Bem, Vieira Chaves, de Freitas Almeida, Campelo, Lobo. CALANGO: A phylogeny-aware comparative genomics tool for discovering quantitative genotype-phenotype associations across species. Patterns. 2023en_US
dc.identifier.cristinIDFRIDAID 2159432
dc.identifier.doi10.1016/j.patter.2023.100728
dc.identifier.issn2666-3899
dc.identifier.urihttps://hdl.handle.net/10037/30408
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalPatterns
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0en_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)en_US
dc.titleCALANGO: A phylogeny-aware comparative genomics tool for discovering quantitative genotype-phenotype associations across speciesen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)