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dc.contributor.authorLeknessund, Oda
dc.contributor.authorMorelli, Vania Maris
dc.contributor.authorHansen, John Bjarne
dc.contributor.authorBrækkan, Sigrid Kufaas
dc.date.accessioned2023-08-25T11:11:22Z
dc.date.available2023-08-25T11:11:22Z
dc.date.issued2023-06-29
dc.description.abstractBackground - There is limited information on the relationship between muscle strength and recurrence and mortality after incident venous thromboembolism (VTE).<p> <p>Objectives - To investigate whether weak hand grip strength (HGS) was associated with risk of recurrence and mortality in patients with VTE recruited from the general population.<p> <p>Methods - Participants from the Tromsø Study with a first-time VTE (n = 545) were included, and all VTE recurrences and deaths among the participants were recorded in the period 1994 to 2020. Weak HGS was defined as lowest 25th percentile of the general population, and incidence rates for VTE recurrence and mortality according to weak vs normal (>25th percentile) HGS, with 95% CIs, were estimated.<p> <p>Results - There were 90 recurrences and 350 deaths during a median of 3.7 years of follow-up. The fully adjusted hazard ratio (HR) for overall VTE recurrence for those with weak HGS vs those with normal HGS was 2.02 (95% CI, 1.23-3.30). The corresponding HRs for recurrence were 2.22 (95% CI, 1.18-4.17) in patients with a first deep vein thrombosis and 1.60 (95% CI, 0.72-3.57) in patients with a first pulmonary embolism. The cumulative 1-year survival was 74.9% and 77.8% in those with weak and normal HGS, respectively. For overall mortality after incident VTE, the fully adjusted HR for those with weak HGS was 1.34 (95% CI, 1.04-1.72).<p> <p>Conclusion - Weak HGS was associated with an increased risk of recurrent VTE, and the association appeared to be particularly pronounced after incident deep vein thrombosis. There was a slightly lower survival probability among those with weak HGS than among those with normal HGS.en_US
dc.identifier.citationLeknessund, Morelli, Hansen, Brækkan. Hand grip strength in venous thromboembolism: risk of recurrence and mortality. Research and Practice in Thrombosis and Haemostasis (RPTH). 2023;7(5):1-9
dc.identifier.cristinIDFRIDAID 2169035
dc.identifier.doi10.1016/j.rpth.2023.102138
dc.identifier.issn2475-0379
dc.identifier.urihttps://hdl.handle.net/10037/30432
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalResearch and Practice in Thrombosis and Haemostasis (RPTH)
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleHand grip strength in venous thromboembolism: risk of recurrence and mortalityen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's license is described as Attribution 4.0 International (CC BY 4.0)