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dc.contributor.authorXie, Mingxu
dc.contributor.authorLi, Ming
dc.contributor.authorHao, Qiang
dc.contributor.authorOlsen, Rolf-Erik
dc.contributor.authorRingø, Einar
dc.contributor.authorYang, Yalin
dc.contributor.authorZhang, Zhen
dc.contributor.authorRan, Chao
dc.contributor.authorZhou, Zhigang
dc.date.accessioned2023-08-31T11:56:45Z
dc.date.available2023-08-31T11:56:45Z
dc.date.issued2023-03-12
dc.description.abstractProbiotics are reported to improve the nutrition, immunity, and health of fish. Nuclease can hydrolyze nucleic acids of probiotics to produce nucleotides. The present study investigated the effect of stabilized fermentation product of nuclease-treated <i>Lactobacillus rhamnosus</i> GCC-3 (GCC-3 NT) on growth, non-specific immunity, liver health, and gut microbiota of zebrafish (<i>Danio rerio</i>). Compared to the high-fat diet (HFD) group, GCC-3 NT did not affect the growth performance of zebrafish. However, GCC-3 NT treatment can significantly increase the lysozyme activity and the total antioxidant capacity of body surface mucus. In addition, dietary GCC-3 NT significantly reduced the content of hepatic triglycerides (TAG) in zebrafish while significantly increased the expression of acyl-coenzyme A oxidases 3 (ACOX3) and proliferator-activated receptor γ coactivator 1α (PGC1α) compared with the HFD group. The 16S rRNA gene sequencing showed that GCC-3 NT reduced the relative abundance of Actinobacteria while increased Firmicutes at the phylum level. The relative abundance of <i>Rhodococcus</i> was significantly decreased and <i> Lactobacillus</i> and <i>Staphylococcus </i> abundance were significantly increased in the GCC-3 NT group compared to the HFD group. Furthermore, PCoA analysis showed GCC-3 NT diet had a significant effect on the autochthonous microbiota compared to the HFD diet. Together, our results showed that nuclease-treated <i>L. rhamnosus</i> fermentation product can improve the immunity, liver health and gut microbiota of zebrafish, suggesting that it can be potentially used as a functional feed additive for aquaculture.en_US
dc.identifier.citationXie, Li, Hao, Olsen, Ringø, Yang, Zhang, Ran, Zhou. Effects of nuclease-treated fermentation product of Lactobacillus rhamnosus GCC-3 on growth, hepatic health and gut microbiota of zebrafish (Danio rerio) fed a high-fat diet. Aquaculture Reports. 2023;29en_US
dc.identifier.cristinIDFRIDAID 2142777
dc.identifier.doi10.1016/j.aqrep.2023.101529
dc.identifier.issn2352-5134
dc.identifier.urihttps://hdl.handle.net/10037/30596
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalAquaculture Reports
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleEffects of nuclease-treated fermentation product of Lactobacillus rhamnosus GCC-3 on growth, hepatic health and gut microbiota of zebrafish (Danio rerio) fed a high-fat dieten_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Med mindre det står noe annet, er denne innførselens lisens beskrevet som Attribution 4.0 International (CC BY 4.0)