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dc.contributor.authorMeng, Wei
dc.contributor.authorJohnsen, Kay-Martin
dc.contributor.authorFenton, Christopher Graham
dc.contributor.authorFlorholmen, Jon
dc.contributor.authorPaulssen, Ruth H
dc.date.accessioned2023-09-04T09:28:47Z
dc.date.available2023-09-04T09:28:47Z
dc.date.issued2023-05-18
dc.description.abstractDue to the lack of clinical, immunologic, genetic, and laboratory markers to predict remission in ulcerative colitis (UC) without relapse, there is no clear recommendation regarding withdrawal of therapy. Therefore, this study was to investigate if transcriptional analysis together with Cox survival analysis might be able to reveal molecular markers that are specific for remission duration and outcome. Mucosal biopsies from patients in remission with active treatment-naïve UC and healthy control subjects underwent whole-transcriptome RNA-seq. Principal component analysis (PCA) and Cox proportional hazards regression analysis were applied to the remission data concerning duration and status of patients. A randomly chosen remission sample set was used for validation of the applied methods and results. The analyses distinguished two different UC remission patient groups with respect to remission duration and outcome (relapse). Both groups showed that altered states of UC with quiescent microscopic disease activity are still present. The patient group with the longest remission duration and no relapse revealed specific and increased expression of antiapoptotic factors belonging to the MTRNR2-like gene family and non-coding RNAs. In summary, the expression of anti-apoptotic factors and non-coding RNAs may contribute to personalized medicine approaches in UC by improving patient stratification for different treatment regimens.en_US
dc.identifier.citationMeng W, Johnsen K, Fenton CG, Florholmen J, Paulssen RH. Anti-apoptotic genes and non-coding RNAs are potential outcome predictors for ulcerative colitis. Functional & Integrative Genomics. 2023;23(2)en_US
dc.identifier.cristinIDFRIDAID 2149485
dc.identifier.doi10.1007/s10142-023-01099-9
dc.identifier.issn1438-793X
dc.identifier.issn1438-7948
dc.identifier.urihttps://hdl.handle.net/10037/30661
dc.language.isoengen_US
dc.publisherSpringer Natureen_US
dc.relation.journalFunctional & Integrative Genomics
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleAnti-apoptotic genes and non-coding RNAs are potential outcome predictors for ulcerative colitisen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's license is described as Attribution 4.0 International (CC BY 4.0)