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dc.contributor.authorBugge, Erlend
dc.contributor.authorWynn, Rolf
dc.contributor.authorMollnes, Tom Eirik
dc.contributor.authorReitan, Solveig Merete Klæbo
dc.contributor.authorLapid, Maria I.
dc.contributor.authorGrønli, Ole Kristian
dc.date.accessioned2023-09-04T10:25:49Z
dc.date.available2023-09-04T10:25:49Z
dc.date.issued2022-12-17
dc.description.abstractIn recent years, a connection between depression and inflammation has been established, with a range of immunological changes, both cellular and humoral, presenting during depressive states (Beydoun et al., 2016; Haapakoski et al., 2015; Wium-Andersen et al., 2013). Furthermore, there seems to be a dose-response relationship between depression and inflammation, in the sense that the more severe the depression, the higher the level of systemic inflammation markers, most notably expressed as elevated levels of C-reactive protein (CRP) in peripheral blood (Kohler-Forsberg et al., 2017). Accordingly, CRP has been suggested as a marker of depression severity and depression subtypes, as well as an indicator of specific symptom profiles (Jokela et al., 2016). Furthermore, inflammation has been suggested as a target for treatment with immunomodulatory drugs (Alexopoulos and Morimoto, 2011; Kohler et al., 2014).<p> <p>However, the research populations are predominantly younger adults, mainly in clinical settings, and there are few community-based studies providing comparative analyses of age-groups, or focusing specifically on the older population. For those that do, the results are inconsistent, as some demonstrate an association between CRP and depression (Bondy et al., 2021; Sonsin-Diaz et al., 2020; White et al., 2017), while others do not (Baune et al., 2012; Bremmer et al., 2008; Eurelings et al., 2015; Penninx et al., 2003). Thus, it is still unclear whether the inflammation in depression unfolds to the same extent in depressed older adults as in younger adults, and how the severity of the depression relates to inflammation in different age groups.en_US
dc.identifier.citationBugge E, Wynn R, Mollnes TE, Reitan SKR, Lapid MI, Grønli OK. C-reactive protein levels and depression in older and younger adults - A study of 19,947 individuals. The Tromsø study. Brain, Behavior, and Immunity - Health (BBI - Health). 2023;27en_US
dc.identifier.cristinIDFRIDAID 2091036
dc.identifier.doi10.1016/j.bbih.2022.100571
dc.identifier.issn2666-3546
dc.identifier.urihttps://hdl.handle.net/10037/30665
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalBrain, Behavior, and Immunity - Health (BBI - Health)
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleC-reactive protein levels and depression in older and younger adults - A study of 19,947 individuals. The Tromsø studyen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Med mindre det står noe annet, er denne innførselens lisens beskrevet som Attribution 4.0 International (CC BY 4.0)