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dc.contributor.authorRimvall, Martin Køster
dc.contributor.authorVassard, Ditte
dc.contributor.authorNielsen, Sabrina Mai
dc.contributor.authorWolf, Rasmus Trap
dc.contributor.authorPlessen, Kerstin J.
dc.contributor.authorBilenberg, Niels
dc.contributor.authorThomsen, Per Hove
dc.contributor.authorThastum, Mikael
dc.contributor.authorNeumer, Simon-Peter
dc.contributor.authorPuggaard, Louise Berg
dc.contributor.authorPedersen, Mette Maria Agner
dc.contributor.authorPagsberg, Anne Katrine
dc.contributor.authorSilverman, Wendy K.
dc.contributor.authorCorrell, Christoph U.
dc.contributor.authorChristensen, Robin
dc.contributor.authorJeppesen, Pia
dc.date.accessioned2023-09-06T07:51:40Z
dc.date.available2023-09-06T07:51:40Z
dc.date.issued2023-06-04
dc.description.abstractMind My Mind (MMM) cognitive behavioral therapy (CBT) manualized treatment is effective in the management of common emotional and behavioral mental health problems in youth, yet not all individuals respond satisfactorily to treatment. This study explored potential effect modifiers, i.e., baseline factors associated with a differential treatment effect. We conducted secondary effect modifier analyses with MMM trial data, which involved randomization of 396 youths aged 6–16 years to either MMM CBT treatment (9–13 sessions) or management as usual in local community settings. We examined sociodemographic- (sex, age, family composition, ethnicity, parental education, and income) and clinical variables (mental disorders and duration of mental health problems) as potential effect modifiers of the a) change in parent-rated impact of mental health problems measured by the Strengths and Difficulties Questionnaire (SDQ) or b) response (reduction of ≥1 on SDQ-impact). In intention-to-treat analyses, superior treatment (net) benefits from the MMM intervention were found among youths who met criteria for any mental disorder at baseline (-1.25 [95%CI: -1.67;-0.82]) compared to youths that did not meet diagnostic criteria (-0.22 [95%CI:-1.09;0.65]). Comorbidity vs no comorbidity (- 1.84 [95%CI:-2.58;-1.10] vs -0.72 [95%CI:-1.15;-0.29]) and longer duration of untreated mental health problems, i.e., more vs less than 6 months (-1.16 [95%CI:-1.55;-0.78] vs 0.43 [95%CI:- 1.01;1.86]) were also associated with superior treatment benefits. The sociodemographic factors were not associated with differential treatment effects in the intention-to-treat analyses. These findings suggest that community-based programs like the MMM are well-suited for youths with substantial mental health problems. Clinical Trials Identifier: NCT03535805en_US
dc.identifier.citationRimvall, Vassard, Nielsen, Wolf, Plessen, Bilenberg, Thomsen, Thastum, Neumer, Puggaard, Pedersen, Pagsberg, Silverman, Correll, Christensen, Jeppesen. Effect modification of an effective transdiagnostic cognitive behavioral psychotherapy in youths with common mental health problems: Secondary analyses of the randomized mind-my-mind trial. European Neuropsychopharmacology. 2023;74:64-75en_US
dc.identifier.cristinIDFRIDAID 2169308
dc.identifier.doi10.1016/j.euroneuro.2023.05.004
dc.identifier.issn0924-977X
dc.identifier.issn1873-7862
dc.identifier.urihttps://hdl.handle.net/10037/30715
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalEuropean Neuropsychopharmacology
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleEffect modification of an effective transdiagnostic cognitive behavioral psychotherapy in youths with common mental health problems: Secondary analyses of the randomized mind-my-mind trialen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's license is described as Attribution 4.0 International (CC BY 4.0)