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dc.contributor.authorHindenes, Lars Bakke
dc.contributor.authorIngebrigtsen, Tor
dc.contributor.authorIsaksen, Jørgen Gjernes
dc.contributor.authorHåberg, Asta
dc.contributor.authorJohnsen, Liv-Hege
dc.contributor.authorHerder, Marit
dc.contributor.authorMathiesen, Ellisiv B.
dc.contributor.authorVangberg, Torgil Riise
dc.date.accessioned2023-09-06T08:00:59Z
dc.date.available2023-09-06T08:00:59Z
dc.date.issued2023-07-25
dc.description.abstractPurpose: Studies on patients suggest an association between anatomical variations in the Circle of Willis (CoW) and intracranial aneurysms (IA), but it is unclear whether this association is present in the general population. In this cross-sectional population study, we investigated the associations between CoW anatomical variations and IA.<p> <p>Methods: We included 1667 participants from a population sample with 3 T MRI time-of-flight angiography (40–84 years, 46.5% men). Saccular IAs were defined as protrusions in the intracranial arteries ≥2 mm, while variants of the CoW were classified according to whether segments were missing or hypoplastic (< 1 mm). We used logistic regression, adjusting for age and IA risk factors, to assess whether participants with incomplete CoW variants had a greater prevalence of IA and whether participants with specific incomplete variants had a greater prevalence of IA. <p>Results: Participants with an incomplete CoW had an increased prevalence of IA (OR, 2.3 [95% CI 1.05–5.04]). This was mainly driven by the variant missing all three communicating arteries (OR, 4.2 [95% CI 1.7–1 0.3]) and the variant missing the P1 segment of the posterior cerebral artery (OR, 3.6 [95% CI 1.2–10.1]). The combined prevalence of the two variants was 15.4% but accounted for 28% of the IAs. <p>Conclusion: The findings suggest that an incomplete CoW is associated with an increased risk of IA for adults in the general population.en_US
dc.identifier.citationHindenes, Ingebrigtsen, Isaksen, Håberg, Johnsen, Herder, Mathiesen, Vangberg. Anatomical variations in the circle of Willis are associated with increased odds of intracranial aneurysms: The Tromsø study. Journal of the Neurological Sciences. 2023;452en_US
dc.identifier.cristinIDFRIDAID 2170558
dc.identifier.doi10.1016/j.jns.2023.120740
dc.identifier.issn0022-510X
dc.identifier.issn1878-5883
dc.identifier.urihttps://hdl.handle.net/10037/30716
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalJournal of the Neurological Sciences
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0en_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)en_US
dc.titleAnatomical variations in the circle of Willis are associated with increased odds of intracranial aneurysms: The Tromsø studyen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)