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dc.contributor.authorKollerud, Ruby Del Risco
dc.contributor.authorHaugnes, Hege Sagstuen
dc.contributor.authorClaussen, Bjørgulf
dc.contributor.authorThoresen, Magne
dc.contributor.authorNafstad, Per
dc.contributor.authorFarnham, James
dc.contributor.authorBlaasaas, Karl Gerhard
dc.contributor.authorNæss, Øyvind
dc.contributor.authorCannon-Albright, Lisa A.
dc.date.accessioned2023-09-12T08:45:36Z
dc.date.available2023-09-12T08:45:36Z
dc.date.issued2020-03-06
dc.description.abstractSimilar family-based cancer and genealogy data from Norway and Utah allowed comparisons of the incidence of testicular cancer (TC), and exploration of the role of Scandinavian ancestry and family history of TC in TC risk. Our study utilizes data from the Utah Population Database and Norwegian Population Registers. All males born during 1951–2015 were followed for TC until the age of 29 years. A total of 1,974,287 and 832,836 males were born in Norway and Utah, respectively, of whom 2,686 individuals were diagnosed with TC in Norway and 531 in Utah. The incidence per year of TC in Norway (10.6) was twice that observed in Utah (5.1) for males born in the last period (1980–1984). The incidence rates of TC in Utah did not differ according to the presence or absence of Scandinavian ancestry (p = 0.669). Having a brother diagnosed with TC was a strong risk factor for TC among children born in Norway and Utah, with HR = 9.87 (95% CI 5.68–17.16) and 6.02 (95% CI 4.80–7.55), respectively; with even higher HR observed among the subset of children in Utah with Scandinavian ancestry (HR = 12.30, 95% CI 6.78–22.31). A clear difference in TC incidence among individuals born in Norway and descendants of Scandinavian people born in Utah was observed. These differences in TC rates point to the possibility of environmental influence. Family history of TC is a strong risk factor for developing TC in both populations.en_US
dc.identifier.citationKollerud RdRd, Haugnes h, Claussen B, Thoresen M, Nafstad P, Farnham, Blaasaas KG, Næss Ø, Cannon-Albright L. A population-based study of testicular cancer risk among children and young adults from Norway and Utah, USA.. International Journal of Cancer. 2020;147(6)en_US
dc.identifier.cristinIDFRIDAID 1803284
dc.identifier.doi10.1002/ijc.32949
dc.identifier.issn0020-7136
dc.identifier.issn1097-0215
dc.identifier.urihttps://hdl.handle.net/10037/30936
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.journalInternational Journal of Cancer
dc.relation.projectIDStiftelsen Dam: 2016/FO76902en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2020 The Author(s)en_US
dc.titleA population-based study of testicular cancer risk among children and young adults from Norway and Utah, USA.en_US
dc.type.versionacceptedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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