Show simple item record

dc.contributor.authorJohansen, Terje
dc.contributor.authorLamark, Trond
dc.date.accessioned2023-09-14T12:05:56Z
dc.date.available2023-09-14T12:05:56Z
dc.date.issued2011-03-01
dc.description.abstractMounting evidence suggests that autophagy is a more selective process than originally anticipated. The discovery and characterization of autophagic adapters, like p62 and NBR1, has provided mechanistic insight into this process. p62 and NBR1 are both selectively degraded by autophagy and able to act as cargo receptors for degradation of ubiquitinated subtstrates. A direct interaction between these autophagic adapters and the autophagosomal marker protein LC3, mediated by a so-called LIR (LC3-interacting region) motif, their inherent ability to polymerize or aggregate as well as their ability to specifically recognize substrates are required for efficient selective autophagy. These three required features of autophagic cargo receptors are evolutionarily conserved and also employed in the yeast cytoplasm-to-vacuole targeting (Cvt) pathway and in the degradation of P granules in C. elegans. Here, we review the mechanistic basis of selective autophagy in mammalian cells discussing the degradation of misfolded proteins, p62 bodies, aggresomes, mitochondria and invading bacteria. The emerging picture of selective autophagy affecting the regulation of cell signaling with consequences for oxidative stress responses, tumorigenesis and innate immunity is also addressed.en_US
dc.identifier.citationJohansen T, Lamark T. Selective autophagy mediated by autophagic adapter proteins. Autophagy. 2011;7(3):279-296en_US
dc.identifier.cristinIDFRIDAID 828445
dc.identifier.doi10.4161/auto.7.3.14487
dc.identifier.issn1554-8627
dc.identifier.issn1554-8635
dc.identifier.urihttps://hdl.handle.net/10037/30995
dc.language.isoengen_US
dc.publisherTaylor & Francisen_US
dc.relation.journalAutophagy
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright © 2011 Landes Bioscienceen_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc/3.0/
dc.rightsAttribution-NonCommercial 3.0 Unported (CC BY-NC 3.0)
dc.titleSelective autophagy mediated by autophagic adapter proteinsen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


File(s) in this item

Thumbnail

This item appears in the following collection(s)

Show simple item record

Attribution-NonCommercial 3.0 Unported (CC BY-NC 3.0)
Except where otherwise noted, this item's license is described as Attribution-NonCommercial 3.0 Unported (CC BY-NC 3.0)