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dc.contributor.authorLjungquist, Oskar
dc.contributor.authorHaldorsen, Bjørg
dc.contributor.authorPöntinen, Anna Kaarina
dc.contributor.authorJanice, Jessin
dc.contributor.authorJosefsen, Ellen Haldis
dc.contributor.authorElstrøm, Petter
dc.contributor.authorKacelnik, Oliver
dc.contributor.authorSundsfjord, Arnfinn
dc.contributor.authorSamuelsen, Ørjan
dc.contributor.authorHandal, Nina
dc.contributor.authorRanheim, Trond Egil
dc.contributor.authorHansen, Bent-Are
dc.contributor.authorMjøen, Andreas Fossum
dc.contributor.authorLindemann, Paul Christoffer
dc.contributor.authorNilsen, Einar
dc.contributor.authorZaragkoulias, Kyriakos
dc.contributor.authorLarsen, Hege Elisabeth
dc.contributor.authorBjørnholt, Jørgen
dc.contributor.authorGammelsrud, Karianne Wiger
dc.contributor.authorJakovljev, Aleksandra
dc.contributor.authorLöhr, Iren Høyland
dc.contributor.authorBredberg, Anders
dc.contributor.authorMarvik, Åshild
dc.contributor.authorMinge, Christina
dc.contributor.authorTofteland, Ståle
dc.contributor.authorPapp, Kristina
dc.contributor.authorOnken, Annette
dc.contributor.authorWeme, Einar Tollaksen
dc.contributor.authorGuennigsman, Brian Albert
dc.date.accessioned2023-09-27T06:00:50Z
dc.date.available2023-09-27T06:00:50Z
dc.date.issued2023-07-06
dc.description.abstractNational and regional carbapenemaseproducing Enterobacterales (CPE) surveillance is essential to understand the burden of antimicrobial resistance, elucidate outbreaks, and develop infection-control or antimicrobial-treatment recommendations. Aim: This study aimed to describe CPE and their epidemiology in Norway from 2015 to 2021. Methods: A nationwide, population-based observational study of all verified clinical and carriage CPE isolates submitted to the national reference laboratory was conducted. Isolates were characterised by antimicrobial susceptibility testing, whole genome sequencing (WGS) and basic metadata. Annual CPE incidences were also estimated. Results: A total of 389 CPE isolates were identified from 332 patients of 63years median age (range:0–98). These corresponded to 341 cases, 184 (54%) being male. Between 2015 and 2021, the annual incidence of CPE cases increased from 0.6 to 1.1per 100,000person-years. For CPEisolates with available data on colonisation/infection, 58% (226/389)were associated with colonisation and 38% (149/389) with clinical infections. WGS revealed a predominance of OXA-48-like (51%; 198/389) and NDM (34%; 134/389) carbapenemases in a diversified population of Escherichia coli and Klebsiella pneumoniae, including high-risk clones also detected globally. Most CPE isolates were travel-related (63%;245/389). Although local outbreaks and healthcare-associated transmission occurred, no interregional spread was detected. Nevertheless, 18% (70/389) of isolates not directly related to import points towards potentially unidentified transmission routes. A decline in travelassociated cases was observed during the COVID-19 pandemic. Conclusions: The close-to-doubling of CPE case incidence between 2015 and 2021 was associated with foreign travel and genomic diversity. To limit further transmission and outbreaks, continued screening and monitoring is essential.en_US
dc.identifier.citationLjungquist, Haldorsen, Pöntinen, Janice, Josefsen, Elstrøm, Kacelnik, Sundsfjord, Samuelsen, Handal, Ranheim, Hansen, Mjøen, Lindemann, Nilsen, Zaragkoulias, Larsen, Bjørnholt, Gammelsrud, Jakovljev, Löhr, Bredberg, Marvik, Minge, Tofteland, Papp, Onken, Weme, Guennigsman. Nationwide, population-based observational study of the molecular epidemiology and temporal trend of carbapenemase-producing Enterobacterales in Norway, 2015 to 2021. Eurosurveillance. 2023;28(27):1-11en_US
dc.identifier.cristinIDFRIDAID 2178045
dc.identifier.doi10.2807/1560-7917.es.2023.28.27.2200774
dc.identifier.issn1025-496X
dc.identifier.issn1560-7917
dc.identifier.urihttps://hdl.handle.net/10037/31222
dc.language.isoengen_US
dc.publisherEuropean Centre for Disease Prevention and Controlen_US
dc.relation.journalEurosurveillance
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleNationwide, population-based observational study of the molecular epidemiology and temporal trend of carbapenemase-producing Enterobacterales in Norway, 2015 to 2021en_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Med mindre det står noe annet, er denne innførselens lisens beskrevet som Attribution 4.0 International (CC BY 4.0)