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dc.contributor.authorvan der Heide, Frank C. T.
dc.contributor.authorKhawaja, Anthony
dc.contributor.authorBerendschot, Tos T. J. M.
dc.contributor.authorLittlejohns, Thomas J.
dc.contributor.authorKuźma, Elżbieta
dc.contributor.authorLuben, Robert
dc.contributor.authorPatel, Praveen J.
dc.contributor.authorFoster, Paul J.
dc.contributor.authorBertelsen, Geir
dc.contributor.authorvon Hanno, Therese
dc.contributor.authorJohnsen, Bente
dc.contributor.authorSchirmer, Henrik
dc.contributor.authorRebouças, Sara C. L.
dc.contributor.authorGrasset, Leslie
dc.contributor.authorDelcourt, Cécile
dc.contributor.authorHelmer, Catherine
dc.contributor.authorStehouwer, Coen D. A.
dc.date.accessioned2023-11-21T12:50:38Z
dc.date.available2023-11-21T12:50:38Z
dc.date.issued2023-08-08
dc.description.abstractINTRODUCTION - Our main objective was to investigate whether retinal neurodegeneration, estimated from lower thickness of inner retinal layers, was associated with incident all-cause dementia and Alzheimer's disease (AD).<p> <p>METHODS - We performed an individual participant data meta-analysis using unpublished data from four prospective cohort studies with a total of 69,955 participants (n = 1087 cases of incident all-cause dementia; n = 520 cases incident AD; follow-up time median [interquartile range] 11.3 [8.8–11.5] years).<p> <p>RESULTS - General baseline characteristics of the study population were mean (standard deviation) age, 58.1 (8.8) years; 47% women. After adjustment, lower baseline macular retinal nerve fiber layer thickness was significantly associated with a 10% and 11% higher incidence of all-cause dementia and AD, respectively. Lower baseline macular ganglion cell-inner plexiform layer thickness was not significantly associated with these outcomes.<p> <p>DISCUSSION - These findings suggest that retinal neurodegeneration precedes the onset of clinical dementia. Retinal imaging tools may be informative biomarkers for the study of the early pathophysiology of dementia.en_US
dc.identifier.citationvan der Heide, Khawaja, Berendschot, Littlejohns, Kuźma, Luben, Patel, Foster, Bertelsen, von Hanno, Johnsen, Schirmer, Rebouças, Grasset, Delcourt, Helmer, Stehouwer. Associations of inner retinal layers with risk of incident dementia: An individual participant data analysis of four prospective cohort studies. Alzheimer's & Dementia. 2023
dc.identifier.cristinIDFRIDAID 2178027
dc.identifier.doi10.1002/alz.13167
dc.identifier.issn1552-5260
dc.identifier.issn1552-5279
dc.identifier.urihttps://hdl.handle.net/10037/31844
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.journalAlzheimer's & Dementia
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0en_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)en_US
dc.titleAssociations of inner retinal layers with risk of incident dementia: An individual participant data analysis of four prospective cohort studiesen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)