Institutt for klinisk medisin: Recent submissions
Now showing items 1301-1320 of 1974
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Serum osteoprotegerin and renal function in the general population: The Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-10-03)<p><i>Background</i>: Serum osteoprotegerin (OPG) is elevated in patients with chronic kidney disease (CKD) and increases with decreasing renal function. However, there are limited data regarding the association between OPG and renal function in the general population. The aim of the present study was to explore the relation between serum OPG and renal function in subjects recruited from the general ... -
Effect of the anticoagulant, storage time and temperature of blood samples on the concentrations of 27 multiplex assayed cytokines – Consequences for defining reference values in healthy humans
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-06-06)Cytokines are potentially useful biomarkers of sepsis and other inflammatory conditions. Many cytokines can be released by leukocytes and platelets after sampling. The sampling and processing techniques are consequently critically important to measure the <i>in vivo</i> levels. We therefore examined the effects of four different anticoagulants, EDTA, citrate, lepirudin, heparin compared to serum, ... -
An Acylation-Finkelstein Approach to Radioiodination of Bioactives: The Role of Amide Group Anchimeric Assistance
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-02-28)Herein, we report a straightforward sequential acylation‐Finkelstein approach to achieve iodination of amine containing bioactives. The utility was demonstrated by successful radiolabelling with <sup>123</sup>I in high radiochemical yield. Moreover, microwave‐assisted Finkelstein reaction can be employed to enhance conversion and reaction rates to obtain the desired iodides. The method is of interest ... -
The interplay between global standards and local practice in nursing
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013-05-17)<p><i>Purpose</i>: The paper assesses the extent, form, and transformation of global nursing classifications (NANDA) in a nursing practice during a period of 5 years.</p> <p><i>Method</i>: A longitudinal case study was used to trace implementation, adoption and use of nursing classifications as an integral part of an electronic nursing module. A mixed method of data collection was used, including ... -
A randomized trial of telemedicine efficacy and safety for nonacute headaches
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-07-11)<p><i>Objective</i>: To evaluate long-term treatment efficacy and safety of one-time telemedicine consultations for nonacute headaches.</p> <p><i>Methods</i>: We randomized, allocated, and consulted nonacute headache patients via telemedicine (n = 200) or in a traditional manner (n = 202) in a noninferiority trial. Efficacy endpoints, assessed by questionnaires at 3 and 12 months, included change ... -
Criteria for failure and worsening after surgery for lumbar disc herniation: a multicenter observational study based on data from the Norwegian Registry for Spine Surgery
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-06-14)PURPOSE: In clinical decision-making, it is crucial to discuss the probability of adverse outcomes with the patient. A large proportion of the outcomes are difficult to classify as either failure or success. Consequently, cutoff values in patient-reported outcome measures (PROMs) for "failure" and "worsening" are likely to be different from those of "non-success". The aim of this study was to identify ... -
Long-term dropout from school and work and mental health in young adults in Norway: A qualitative interview-based study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-03-22)School dropout is related to difficult life trajectories in Western society. Developing effective preventive interventions is urgent. Nevertheless, few studies have interviewed unemployed young adults in the aftermath of school dropout to understand their experiences with influential factors. We interviewed seven former students two to five years after they had dropped out and seven same-aged students ... -
More histologic and ultrastructural degenerative signs in the subscapularis tendon and the joint capsule in male patients with shoulder impingement
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-03-02)<p><i>Purpose</i>: The purpose of the present study was to analyze biopsy samples from the subscapularis tendon and from the joint capsule from male patients with shoulder impingement syndrome (SAIS) and compare them with samples from male patients with post-traumatic recurrent shoulder instability. The hypothesis of the study was that patients with SAIS would have more histologic and ultrastructural ... -
Reduced inflammatory response by transcatheter, as compared to surgical aortic valve replacement
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-12-12)<i>Objectives</i>. The inflammatory response to on-pump cardiac surgery is well known. Systemic inflammatory response syndrome after transcatheter valve implantation (TAVI) has been reported. The objective of this study was to study the inflammatory response during TAVI, and compare with the response during surgical aortic valve replacement. <i>Methods</i>. Eighteen patients undergoing transcatheter ... -
First-aid training in school: amount, content and hindrances
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-08-17)<p><i>Background</i>: To increase knowledge and competence about first aid in the population, first‐aid instruction is included in primary and secondary school curricula. This study aimed to establish how much time is spent on first‐aid training, which first‐aid measures are taught, and which factors prevent teachers from providing the quantity and quality of first‐aid training that they wish to ... -
CTLA-4 expression in the non-small cell lung cancer patient tumor microenvironment: diverging prognostic impact in primary tumors and lymph node metastases
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-07-13)The immune checkpoint receptor CTLA-4 plays a crucial part in negatively regulating T cell activation and maintaining self-tolerance. It is frequently overexpressed in a variety of malignancies, yet its prognostic impact in non-small cell lung cancer (NSCLC) remains unclear. We constructed tissue microarrays from tumor tissue samples and evaluated the immunohistochemical expression of CTLA-4 in 536 ... -
Adverse events in hospitalised cancer patients: a comparison to a general hospital population
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-04-05)<p><i>Background</i>: Patients with cancer are often treated by many healthcare providers, receive complex and potentially toxic treatments that can increase the risk for iatrogenic harm. The aim of this study is to investigate whether hospitalised cancer patients are at higher risk of adverse events (AEs) compared to a general hospital population.</p> <p><i>Material and methods</i>: A total of ... -
Does a parent-administrated early motor intervention influence general movements and movement character at 3 months of age in infants born preterm?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-06-30)<p><i>Background</i>: Studies of preterm and term-born infants have shown absent fidgety movements and an abnormal movement character to be related to brain lesions and unfavourable neurological outcomes.</p> <p><i>Aims</i>: The present study examines what effect a parent-administered early intervention program applied to preterm infants in a randomised control trial (RCT) between 34 and 36 ... -
Are severely injured trauma victims in Norway offered advanced pre-hospital care? National, retrospective, observational cohort
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-06-26)<p><i>Background</i>: Studies of severely injured patients suggest that advanced pre‐hospital care and/or rapid transportation provides a survival benefit. This benefit depends on the disposition of resources to patients with the greatest need. Norway has 19 Emergency Helicopters (HEMS) staffed by anaesthesiologists on duty 24/7/365. National regulations describe indications for their use, and the ... -
Performance of Norwegian civilian EMTs and army medics in penetrating trauma: a controlled simulation-based assessment
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-05-25)<p><i>Background</i>: Penetrating trauma kills rapidly. Thorough and efficient examination and aggressive hemorrhage control is important to save lives. The aim of this study was to assess the skills of civilian Emergency Medical Technicians (EMTs) in bleeding examination and control compared to Army Medics. Our hypothesis was that civilian pre‐hospital systems perform at a lower level compared to ... -
The Glasgow prognostic score: Useful information when prescribing palliative radiotherapy
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-04-26)The purpose of the present retrospective study was to investigate whether a score reflecting systemic inflammatory processes [the Glasgow Prognostic Score (GPS)] provides relevant information for radiation oncologists. GPS is a three‑tiered score [0: normal C-reactive protein (CRP) and albumin; 1: one abnormal result; 2: increased CRP and low albumin]. Correlations between disease type and extent, ... -
The effect of high-dose vitamin D3 supplementation on bone mineral density in subjects with prediabetes
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-09-18)<p><i>Summary</i> The rationale of this study was to determine the effect of high-dose vitamin D3 supplementation on bone mineral density (BMD). Prediabetic males given vitamin D had significantly less reduction in BMD at the femoral neck compared to the controls. The clinical implications of our findings require further investigation.</p> <p><i>Introduction</i> Type 2 diabetes mellitus is ... -
Local Control and overall survival after frameless radiosurgery: A single center experience
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-11-06)<p><i>Introduction</i> Stereotactic radiosurgery (SRS) has been increasingly advocated for 1–3 small brain metastases. The goal of this study was to evaluate the clinical results in patients with brain metastases treated with LINAC-based SRS using a thermoplastic mask (non-invasive fixation system) and Image-Guided Radiotherapy (IGRT).</p> <p><i>Material and Methods</i> In this single-institution ... -
A Three-Variable Model Predicts Short Survival in Patients With Newly Diagnosed Metastatic Renal Cell Carcinoma
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-02-21)<p><i>Background</i> Patients with metastatic renal cell carcinoma (mRCC) have variable survival outcomes. When discussing management approaches and providing information to patients and caregivers, it is important to have realistic perspectives, especially if the expected prognosis is very unfavorable. In the present study, factors predicting this endpoint were analyzed.</p> <p><i>Methods</i> Data ... -
Calculating the 30-day survival in acute myocardial infarction: should we use the treatment chain or the hospital catchment model?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-01-12)<p><i>Introduction</i> Acute myocardial infarction (AMI) is a potentially deadly disease and significant efforts have been concentrated on improving hospital performance. A 30-day survival rate has become a key quality of care indicator. In Northern Norway, some patients undergoing AMI are directly transferred to the Regional Cardiac Intervention Center at the University Hospital of North Norway ...