Institutt for klinisk medisin: Recent submissions
Now showing items 181-200 of 1804
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Hofteleddsdysplasi hos spedbarn – screening, behandling og oppfølging
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-04-19)Hofteleddsdysplasi forkommer hos opptil 3 % av nyfødte og kan ubehandlet føre til luksert hofteledd, osteoartritt og behov for hofteprotese. Målet med studien var å kartlegge rutiner for ultralydscreening, behandling og oppfølging av hofteleddsdysplasi ved norske sykehus. -
High Expression of IRS-1, RUNX3 and SMAD4 Are Positive Prognostic Factors in Stage I–III Colon Cancer
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-24)Colon cancer is a common malignancy and a major contributor to human morbidity and mortality. In this study, we explore the expression and prognostic impact of IRS-1, IRS-2, RUNx3, and SMAD4 in colon cancer. Furthermore, we elucidate their correlations with miRs 126, 17-5p, and 20a-5p, which are identified as potential regulators of these proteins. Tumor tissue from 452 patients operated for stage ... -
Spinal Anaesthesia as an Adjunct to General Anaesthesia for Laparoscopic Abdominoperineal Rectal Amputation
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-31)Background: Spinal anaesthesia as an adjunct to general anaesthesia may reduce postoperative pain and opioid consumption after laparoscopic abdominoperineal rectal amputation. We designed a randomized double blinded pilot study with two objectives: 1) to explore potential benefits of spinal anaesthesia as an adjunct to general anaesthesia and 2) to provide power and sample size estimations for ... -
Potato Ethics: What Rural Communities Can Teach Us about Healthcare
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-04-12)In this paper I ofer the term “potato ethics” to describe a particular professional rural health sensibility. I contrast this attitude with the sensibility behind urban professional ethics, which often focus on the narrow doctor–patient treatment relationship. The phrase appropriates a Swedish metaphor, the image of the potato as a humble side dish: plain, useful, versatile, and compatible with ... -
Rusutløst psykose – en problematisk diagnose
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-20)Hvert år legges over 500 pasienter inn på norske sykehus med diagnosen rusutløst psykose. Men rusmiddelbruk er bare én av flere bidragende faktorer til at disse pasientene blir psykotiske, og mange får senere en schizofrenidiagnose. -
E. Sverre og medarbeidere svarer
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-20) -
Gut microbiota composition during hospitalization is associated with 60-day mortality after severe COVID-19
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-23)Background - Gut microbiota alterations have been reported in hospitalized COVID-19 patients, with reduced alpha diversity and altered microbiota composition related to respiratory failure. However, data regarding gut microbiota and mortality are scarce.<p> <p>Methods - Rectal swabs for gut microbiota analyses were collected within 48 h after hospital admission (baseline; n = 123) and three-month ... -
VTE epidemiology and challenges for VTE prevention at the population level: VTE epidemiology
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-17)Venous thromboembolism (VTE) is a frequent disease affecting more than 1 in 12 individuals during their lifetime. VTE is associated with a substantial disease burden due to long-term complications such as recurrence, the post-thrombotic syndrome, and the post-pulmonary embolism syndrome. Despite the knowledge of several risk factors and triggers, more than one third of the VTE events occur in the ... -
Early diagnosis and better rhythm management to improve outcomes in patients with atrial fibrillation: the 8th AFNET/EHRA consensus conference
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-27)Despite marked progress in the management of atrial fibrillation (AF), detecting AF remains difficult and AF-related complications cause unacceptable morbidity and mortality even on optimal current therapy. This document summarizes the key outcomes of the 8th AFNET/EHRA Consensus Conference of the Atrial Fibrillation NETwork (AFNET) and the European Heart Rhythm Association (EHRA). Eighty-three ... -
Autoimmune disease and risk of postpartum venous thromboembolism
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-23)Background - The risk of pregnancy-related mortality in the United States has nearly doubled since 1990, with venous thromboembolism (VTE) accounting for approximately 10% of these deaths.<p> <p>Objectives - The objective of this study was to assess whether preexisting autoimmune disease is a risk factor for postpartum VTE.<p> <p>Methods - Using the MarketScan Commercial and Medicare Supplemental ... -
What Drives Animal Fluency Performance in Cantonese-Speaking Chinese Patients with Adult-Onset Psychosis?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-27)Among the numerous studies investigating semantic factors associated with functioning in psychotic patients, most have been conducted on western populations. By contrast, the current cross-sectional study involved native Cantonese-speaking Chinese participants. Using the category fluency task, we compared performance between patients and healthy participants and examined clinical and sociodemographic ... -
Etablering av medisinske sannheter
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-27) -
Methylation-regulated long non-coding RNA expression in ulcerative colitis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-22)Long non-coding RNAs (lncRNAs) have been shown to play a role in the pathogenesis of ulcerative colitis (UC). Although epigenetic processes such as DNA methylation and lncRNA expression are well studied in UC, the importance of the interplay between the two processes has not yet been fully explored. It is, therefore, believed that interactions between environmental factors and epigenetics ... -
Parents’ perspectives on the role of kin in child-rearing: a qualitative study on Greenland’s universal parenting programme MANU
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-21)Nurturing care and protection from parents and community in the early years of life are fundamental for a child’s development. The article aims to explore what relations parents see as meaningful in their child’s upbringing and how these are shaped, and how these perspectives are reflected in MANU. MANU is a universal parenting programme in Greenland. Ten of 40 interviews with parents were selected ... -
Palliative Radiotherapy for Non-metastatic Non-small-cell Lung Cancer: Impact of Blood Test Results on Survival
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03)Background/Aim: Non-small-cell lung cancer (NSCLC) not amenable to curative treatment can be managed with palliative thoracic radiation or chemoradiation, however, with variable success. This study evaluated the prognostic impact of the LabBM score [serum lactate dehydrogenase (LDH), C-reactive protein, albumin, hemoglobin, platelets] in 56 patients who were scheduled to receive at least 10 ... -
Prediction of underlying atrial fibrillation in patients with a cryptogenic stroke: results from the NOR-FIB Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-10)Background - Atrial fibrillation (AF) detection and treatment are key elements to reduce recurrence risk in cryptogenic stroke (CS) with underlying arrhythmia. The purpose of the present study was to assess the predictors of AF in CS and the utility of existing AF-predicting scores in The Nordic Atrial Fibrillation and Stroke (NOR-FIB) Study.<p> <p>Method - The NOR-FIB study was an international ... -
Older patients' experiences of access to and use of e-consultations with the general practitioner in Norway: an interview study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-02)Objective: To explore older patients’ experiences with accessing and using e-consultations to send text-based clinical inquiries to the general practitioner (GP) online.<p> <p>Design: Qualitative study based on semi-structured interviews. Results were analysed through a six-phase thematic analysis and interpreted through Levesque’s framework of patient-centred access to health care. <p>Setting: ... -
Less is more: Antibiotics at the beginning of life
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-04-27)Antibiotic exposure at the beginning of life can lead to increased antimicrobial resistance and perturbations of the developing microbiome. Early-life microbiome disruption increases the risks of developing chronic diseases later in life. Fear of missing evolving neonatal sepsis is the key driver for antibiotic overtreatment early in life. Bias (a systemic deviation towards overtreatment) and noise ... -
Differential profile of protumor immunological factors between the tumor site and the tumor-free site – predictive potential of IL-8 and COX2 for colorectal cancer and metastasis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-04-05)To study the role of host immune surveillance in the initiation and progression of colorectal cancer (CRC), a set of protumor immunological factors was determined by quantitative real-time PCR (q-PCR) between the primary tumor and the adjacent tumor-free site tissues in 63 patients with colorectal neoplasms. Results showed that expression levels of interleukin (IL)-1β, IL-6, IL-8, IL-17A, IL-23, and ... -
Hands-free continuous carotid Doppler ultrasound for detection of the pulse during cardiac arrest in a porcine model
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-20)Background/Purpose - Pulse palpation is an unreliable method for diagnosing cardiac arrest. To address this limitation, continuous hemodynamic monitoring may be a viable solution. Therefore, we developed a novel, hands-free Doppler system, RescueDoppler, to detect the pulse continuously in the carotid artery.<p> <p>Methods - In twelve pigs, we evaluated RescueDoppleŕs potential to measure blood ...