Institutt for klinisk medisin: Recent submissions

Now showing items 361-380 of 1928

    • Cross-Ancestry Investigation of Venous Thromboembolism Genomic Predictors 

      Thibord, Florian; Klarin, Derek; Brody, Jennifer A.; Chen, Ming-Huei; Levin, Michael G.; Chasman, Daniel I.; Goode, Ellen L.; Hveem, Kristian; Teder-Laving, Maris; Martinez-Perez, Angel; Aïssi, Dylan; Daian-Bacq, Delphine; Ito, Kaoru; Natarajan, Pradeep; Lutsey, Pamela L.; Nadkarni, Girish N.; de Vries, Paul S.; Cuellar-Partida, Gabriel; Wolford, Brooke N.; Pattee, Jack W.; Kooperberg, Charles; Brækkan, Sigrid Kufaas; Li-Gao, Ruifang; Saut, Noemie; Sept, Corriene; Germain, Marine; Judy, Renae L.; Wiggins, Kerri L.; Ko, Darae; O'Donnell, Christopher J.; Taylor, Kent D.; Giulianini, Franco; De Andrade, Mariza; Nøst, Therese Haugdahl; Boland, Anne; Empana, Jean-Philippe; Koyama, Satoshi; Gilliland, Thomas; Do, Ron; Huffman, Jennifer E.; Wang, Xin; Zhou, Wei; Manuel Soria, Jose; Carlos Souto, Juan; Pankratz, Nathan; Haessler, Jeffery; Hindberg, Kristian Dalsbø; Rosendaal, Frits R; Turman, Constance; Olaso, Robert; Kember, Rachel L.; Bartz, Traci M.; Lynch, Julie A.; Heckbert, Susan R.; Armasu, Sebastian M.; Brumpton, Ben Michael; Smadja, David M.; Jouven, Xavier; Komuro, Issei; Clapham, Katharine R.; Loos, Ruth J F; Willer, Cristen J.; Sabater-Lleal, Maria; Pankow, James S.; Reiner, Alexander P.; Morelli, Vania Maris; Ridker, Paul M.; Vlieg, Astrid van Hylckama; Deleuze, Jean-François; Kraft, Peter; Rader, Daniel J.; Psaty, Bruce M.; Skogholt, Anne Heidi; Emmerich, Joseph; Suchon, Pierre; Rich, Stephen S.; Vy, Ha My T; Tang, Weihong; Jackson, Rebecca D.; Hansen, John Bjarne; Morange, Pierre-Emmanuel; Kabrhel, Christopher; Trégouët, David-Alexandre; Damrauer, Scott M.; Johnson, Andrew D.; Smith, Nicholas L. (Journal article; Tidsskriftartikkel, 2022)
      <p><i>Background:</i> Venous thromboembolism (VTE) is a life-threatening vascular event with environmental and genetic determinants. Recent VTE genome-wide association studies (GWAS) meta-analyses involved nearly 30 000 VTE cases and identified up to 40 genetic loci associated with VTE risk, including loci not previously suspected to play a role in hemostasis. The aim of our research was to expand ...

    • Factors associated with treatment satisfaction in patients with hidradenitis suppurativa: results from the Global VOICE project 

      Midgette, Bria; Strunk, Andrew; Akilov, Oleg; Alavi, Afsaneh; Ardon, Christine; Bechara, Falk G.; Cohen, Arnon D.; Cohen, Steven; Daveluy, Steven; del Marmol, Véronique; Delage, Maïa; Esmann, Solveig; Fisher, Shani; Giamarellos-Bourboulis, Evangelos J.; Glowaczewska, Amelia; Goldfarb, Noah; Brant, Elena Gonzalez; Grimstad, Øystein; Guilbault, Sandra; Hamzavi, Iltefat; Hughes, Rosalind; Ingram, John R.; Jemec, Gregor B.E.; Ju, Qiang; Kappe, Naomi; Kirby, Brian; Kirby, Joslyn S.; Lowes, Michelle A.; Matusiak, Lukasz; Micha, Stella; Micheletti, Robert; Miller, Angela P.; Moseng, Dagfinn; Naik, Haley; Nassif, Aude; Nikolakis, Georgios; Paek, So Yeon; Pascual, Jose Carlos; Prens, Errol; Resnik, Barry; Riad, Hassan; Sayed, Christopher; Smith, Saxon D.; Soliman, Yssra; Szepietowski, Jacek C.; Tan, Jerry; Thorlacius, Linnea; Tzellos, Thrasyvoulos; van der Zee, Hessel H.; Villumsen, Bente; Wang, Lanqi; Zouboulis, Christos; Garg, Amit (Journal article; Tidsskriftartikkel, 2022-12-01)
      <p><i>Background</i> Nearly half of patients with hidradenitis suppurativa (HS) report dissatisfaction with their treatment. However, factors related to treatment satisfaction have not been explored. <p><i>Objectives</i> To measure associations between treatment satisfaction and clinical and treatment‐related characteristics among patients with HS. <p><i>Methods</i> Treatment satisfaction was ...

    • The mental health consequences on children of the war in Ukraine: A commentary 

      Elvevåg, Brita; DeLisi, Lynn E. (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-08-18)
      The news from Ukraine is currently full of heart-wrenching stories accompanied by graphic images of civilian casualties and massacres that are telecast world-wide on a daily basis. It is hard to fathom the magnitude of the devastation and disruption to regular lives and everyday routines that war brings with it, the witnessing of countless deaths, the associated trauma of living in perpetual fear, ...

    • Plasma levels of platelet-derived microvesicles are associated with risk of future venous thromboembolism 

      Snir, Omri; Wilsgård, line; Latysheva, Nadezhda; Ullsten-Wahlund, Casper; Brækkan, Sigrid Kufaas; Hindberg, Kristian Dalsbø; Hansen, John Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-18)
      Background - Microvesicles (MVs) are small double‐membrane encapsulated particles shed from cells. Case‐control studies have reported elevated plasma levels of platelet‐derived MVs (PDMVs) in patients with venous thromboembolism (VTE). However, it is not known whether high PDMV levels is a risk factor or a consequence of the acute VTE event.<p> <p>Objectives - To investigate the association between ...

    • Joint Effect of Multiple Prothrombotic Genotypes and Mean Platelet Volume on the Risk of Incident Venous Thromboembolism 

      Jakobsen, Lisa; Frischmuth, Tobias; Brækkan, Sigrid Kufaas; Hansen, John Bjarne; Morelli, Vania Maris (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-31)
      Background - A high mean platelet volume (MPV), a marker of increased platelet reactivity, is a risk factor for venous thromboembolism (VTE). Whether established prothrombotic single nucleotide polymorphisms (SNPs) further increase the VTE risk in subjects with high MPV because of biological interaction remains unknown.<p> <p>Aim - To investigate the joint effect of high MPV and prothrombotic ...

    • Prevalence of unruptured intracranial aneurysms: impact of different definitions-the Tromsø Study 

      Johnsen, Liv-Hege; Herder, Marit; Vangberg, Torgil Riise; Kloster, Roar; Ingebrigtsen, Tor; Isaksen, Jørgen Gjernes; Mathiesen, Ellisiv B. (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-06-10)
      Background - Management of incidental unruptured intracranial aneurysms (UIAs) remains challenging and depends on their risk of rupture, estimated from the assumed prevalence of aneurysms and the incidence of aneurysmal subarachnoid haemorrhage. Reported prevalence varies, and consistent criteria for definition of UIAs are lacking. We aimed to study the prevalence of UIAs in a general population ...

    • Physiological Impact of Hypothermia: The Good, the Bad, and the Ugly 

      Tveita, Torkjel; Sieck, Gary C. (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-22)
      Hypothermia is defined as a core body temperature of <35°C, and as body temperature is reduced the impact on physiological processes can be beneficial or detrimental. The beneficial effect of hypothermia enables circulation of cooled experimental animals to be interrupted for 1–2 h without creating harmful effects, while tolerance of circulation arrest in normothermia is between 4 and 5 min. This ...

    • Perceived autonomy support in telerehabilitation by people with chronic respiratory disease: a mixed methods study 

      Cox, Narelle S.; Lee, Joanna Yt; McDonald, Christine F.; Mahal, Ajay; Alison, Jennifer A.; Wootton, Richard; Hill, Catherine J.; Zanaboni, Paolo; O'Halloran, Paul; Bondarenko, Janet; MacDonald, Heather; Barker, Kathryn; Crute, Hayley; Mellerick, Christie; Wageck, Bruna; Boursinos, Helen; Lahham, Aroub; Nichols, Amanda; Czupryn, Pawel; Corbett, Monique; Handley, Emma; Burge, Angela T; Holland, Anne E. (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-12-24)
      Background - Autonomy-supportive health environments can assist patients in achieving behavior change and can influence adherence positively. Telerehabilitation may increase access to rehabilitation services, but creating an autonomy-supportive environment may be challenging.<p> <p>Research Question - To what degree does telerehabilitation provide an autonomy-supportive environment? What is the ...

    • European Society for Radiotherapy and Oncology and European Organisation for Research and Treatment of Cancer consensus on re-irradiation: definition, reporting, and clinical decision making 

      Andratschke, Nicolaus; Willmann, Jonas; Appelt, Ane L; Alyamani, Najlaa; Balermpas, Panagiotis; Baumert, Brigitta G; Hurkmans, Coen; Høyer, Morten; Langendijk, Johannes A.; Kaidar-Person, Orit; van der Linden, Yvette; Meattini, Icro; Niyazi, Maximilian; Reynaert, Nick; De Ruysscher, Dirk; Tanadini-Lang, Stephanie; Hoskin, Peter; Poortmans, Philip; Nieder, Carsten (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-26)
      Re-irradiation can be considered for local recurrence or new tumours adjacent to a previously irradiated site to achieve durable local control for patients with cancer who have otherwise few therapeutic options. With the use of new radiotherapy techniques, which allow for conformal treatment plans, image guidance, and short fractionation schemes, the use of re-irradiation for different sites is ...

    • Independent Validation of a Risk Stratification Model Predicting Survival in Patients With Metastatic Hormone-sensitive Prostate Cancer 

      Nieder, Carsten; Stanisavljevic, Luka (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-05)
      Background/Aim: The aim of this study was to analyze the survival predictions obtained from an online nomogram, originally developed in two US patient cohorts with metastatic hormone-sensitive prostate cancer, because clinical practice and survival outcomes may vary on an international level. Patients and Methods: A retrospective single-institution study of 197 patients, managed according to Norwegian ...

    • Independent External Validation of the METSSS Model Predicting Survival after Palliative Radiotherapy 

      Nieder, Carsten; Mannsåker, Bård; Yobuta, Rosalba (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-26)
      Background/Aim: A validation of the recently published METSSS model (developed from a large US database) predicting survival after palliative radiotherapy was performed. METSSS includes age, sex, cancer type, localization of distant metastases, comorbidity, and radiotherapy site. Patients and Methods: Both 1- and 5-year survival was assessed in the validation cohort. Deviations between model-predicted ...

    • Classic pattern dyssynchrony is associated with outcome in patients with Fontan circulation 

      Rosner, Assami; Diab, Simone Goa; McElhinney, Doff B.; Friedberg, Mark K.; Lui, George K. (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-02)
      Background - Morbidity and mortality increase as Fontan patients age into adulthood. Limited studies have examined cardiac magnetic resonance and echocardiographic parameters to predict death and transplantation in children after the Fontan operation. The aim of this study was to investigate echocardiographic parameters in adolescents and adults after Fontan operation, including myocardial mechanics ...

    • Increasing access to cognitive screening in the elderly: Applying natural language processing methods to speech collected over the telephone 

      Diaz-Asper, Catherine; Chandler, Chelsea; Turner, Raymond S.; Reynolds, Brigid; Elvevåg, Brita (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-08-30)
      Barriers to healthcare access are widespread in elderly populations, with a major consequence that older people are not benefiting from the latest technologies to diagnose disease. Recent advances in the automated analysis of speech show promising results in the identification of cognitive decline associated with Alzheimer's disease (AD), as well as its purported pre-clinical stage. We utilized ...

    • Implementation of Locoregional Adjuvant Radiotherapy for Breast Cancer in a Rural Healthcare Region: Toxicity Outcomes in the Initial Cohort 

      Nieder, Carsten; Ressheim, Joakim Grønning; Haukland, Ellinor Christin; Mannsåker, Bård (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-29)
      Background/Aim: The aim of this study was to analyze the toxicity of locoregional adjuvant breast cancer radiotherapy after implementation of this service in a rural healthcare region with long travel distance. Patients and Methods: This was a retrospective single-institution analysis of 87 consecutive female patients (the initial cohort), managed with conventionally fractionated 3-D conformal ...

    • Feasibility and efficacy of early docetaxel plus androgen deprivation therapy for metastatic hormone-sensitive prostate cancer in a rural health care setting 

      Nieder, Carsten; Stanisavljevic, Luka; Dalhaug, Astrid; Haukland, Ellinor Christin (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-17)
      Aim/Background - The aim of this study was to evaluate the feasibility and efficacy, in terms of overall survival, of intensified upfront systemic therapy in patients with metastatic hormone-sensitive prostate cancer who lived in rural Nordland County, Norway.<p> <p>Patients and methods - Overall 117 patients were included in this retrospective study. Three cohorts were created: early docetaxel ...

    • Survival and Early Death Within Three Months from the Start of Immune Checkpoint Inhibitors in Patients With Different Types of Cancer 

      Nieder, Carsten; Aanes, Siv Gyda; Haukland, Ellinor Christin (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-05-31)
      Background/Aim: Implementation of new anticancer treatments in rural healthcare might not always result in identical survival outcomes as those seen in the randomized trials leading to approval. Therefore, the survival of patients treated with immune checkpoint inhibitors (ICI) in Nordland county was analyzed. Patients and Methods: Retrospective analysis of 199 patients, mainly treated in adjuvant ...

    • Using Automated Speech Processing for Repeated Measurements in a Clinical Setting of the Behavioral Variability in the Stroop Task 

      Holmlund, Terje Bektesevic; Cohen, Alex S; Cheng, Jian; Foltz, Peter W.; Bernstein, Jared; Rosenfeld, Elisabeth; Laeng, Bruno; Elvevåg, Brita (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-04)
      The Stroop interference task is indispensable to current neuropsychological practice. Despite this, it is limited in its potential for repeated administration, its sensitivity and its demands on professionals and their clients. We evaluated a digital Stroop deployed using a smart device. Spoken responses were timed using automated speech recognition. Participants included adult nonpatients (N = ...

    • Extended Coagulation Profiling in Isolated Traumatic Brain Injury: A CENTER-TBI Analysis 

      Böhm, Julia K.; Schaeben, Victoria; Schäfer, Nadine; Güting, Helge; Lefering, Rolf; Thorn, Sophie; Schöchl, Herbert; Zipperle, Johannes; Grottke, Oliver; Rolf, Rossaint; Stanworth, Simon; Curry, Nicola; Maegele, Marc; Åkerlund, Cecilia; Amrein, Krisztina; Andelic, Nada; Andreassen, Lasse; Vik, Anne; Anke, Audny Gabriele Wagner; Antoni, Anna; Audibert, Gérard; Azouvi, Philippe; Frisvold, Shirin; Skandsen, Toril; Helseth, Eirik; Røe, Cecilie; Røise, Olav (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-16)
      Background Trauma-induced coagulopathy in traumatic brain injury (TBI) remains associated with high rates of complications, unfavorable outcomes, and mortality. The underlying mechanisms are largely unknown. Embedded in the prospective multinational Collaborative European Neurotrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study, coagulation profiles beyond standard conventional ...

    • High arterial oxygen levels and supplemental oxygen administration in traumatic brain injury: insights from CENTER-TBI and OzENTER-TBI 

      Petrosino, Matteo; Rezoagli, Emanuele; Rebora, Paola; Menon, David K.; Mondello, Stefania; Cooper, D. James; Maas, Andrew I. R.; Wiegers, Eveline J. A.; Stefania, Galimberti; Citerio, Giuseppe; Nada, Andelic; Andreassen, Lasse; Vik, Anne; Anke, Audny Gabriele Wagner; Frisvold, Shirin; Skandsen, Toril; Helseth, Eirik; Røe, Cecilie; Røise, Olav (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-10-20)
      Purpose The effect of high arterial oxygen levels and supplemental oxygen administration on outcomes in traumatic brain injury (TBI) is debated, and data from large cohorts of TBI patients are limited. We investigated whether exposure to high blood oxygen levels and high oxygen supplementation is independently associated with outcomes in TBI patients admitted to the intensive care unit (ICU) and ...

    • Comparative effectiveness of intracranial hypertension management guided by ventricular versus intraparenchymal pressure monitoring: a CENTER-TBI study 

      Volovici, Victor; Pisică, Dana; Gravesteijn, Benjamin; Dirven, Clemens M. F.; Steyerberg, Ewout W.; Ercole, Ari; Stocchetti, Nino; Nelson, David; Menon, David K; Citerio, Giuseppe; Van Der Jagt, Mathieu; Maas, Andrew I. R.; Haitsma, Iain K.; Lingsma, Hester F.; Vik, Anne; Skandsen, Toril; Andelic, Nada; Røise, Olav; Helseth, Eirik; Andreassen, Lasse; Anke, Audny Gabriele Wagner; Røe, Cecilie (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-06-01)
      <b><p>Objective</b> To compare outcomes between patients with primary external ventricular device (EVD)–driven treatment of intracranial hypertension and those with primary intraparenchymal monitor (IP)–driven treatment. <b><p>Methods</b> The CENTER-TBI study is a prospective, multicenter, longitudinal observational cohort study that enrolled patients of all TBI severities from 62 participating ...