Institutt for klinisk medisin: Recent submissions
Now showing items 521-540 of 1804
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Molecular differences of adipose-derived mesenchymal stem cells between non-responders and responders in treatment of transphincteric perianal fistulas
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-24)Background: Injection of autologous adipose tissue (AT) has recently been demonstrated to be an efective and safe treatment for anal fstulas. AT mesenchymal stem cells (AT-MSCs) mediate the healing process, but the relationship between molecular characteristics of AT-MSCs of the injected AT and fstula healing has not been adequately studied. Thus we aimed to characterize the molecular and functional ... -
Quantitation of linear and branched perfluoroalkane sulfonic acids (PFSAs) in women and infants during pregnancy and lactation
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-24)Background: Per- and polyfluoroalkyl substances (PFAS) are associated with negative health effects, and exposure during fetal life and infancy are of concern. A subgroup of PFAS, linear and branched perfluoroalkane sulfonic acids (PFSA), have significant differences in biochemical reactions, bioaccumulation and potential toxic exposure effects, and data on transfer of PFSA isomers from mother to ... -
Combined effects of plasma von Willebrand factor and platelet measures on the risk of incident venous thromboembolism
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-06-23)Plasma von Willebrand factor (VWF) and platelet reactivity are risk factors for venous thromboembolism (VTE), and VWF can promote hemostasis by interaction with platelets. In this study, we explored the combined effects of plasma VWF and platelet measures on the risk of incident VTE. A population-based nested case-control study with 403 cases and 816 controls was derived from the Tromsø Study. VWF, ... -
Blood pressure-lowering treatment for the prevention of cardiovascular events in patients with atrial fibrillation: An individual participant data meta-analysis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-06-01)Purpose: To evaluate the influence of coma on manifest refractive cylinder (MRC) in eyes with coma-dominated corneal optics and suggest alternative guidelines for surgical planning of astigmatism correction in topography-guided ablation and toric intraocular lens (IOL) exchange surgery.<p> <p>Methods: Twelve eyes with coma-dominant corneal optics and low lenticular astigmatism were selected. The ... -
One-Year Remission Rate of Chronic Headache Comparing Video and Face-to-Face Consultations by Neurologist: Randomized Controlled Trial
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-13)Background: Chronic headache causing severe headache-related disability for those affected by the disease is under- or misdiagnosed in many cases and therefore requires easy access to a specialist for optimal health care management.<p> <p>Objective: The goal of the research is to determine whether video consultations are noninferior to face-to-face consultations in treating chronic headache ... -
Serum miR371 in testicular germ cell cancer before and after orchiectomy, assessed by digital-droplet PCR in a prospective study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-02)MicroRNA-371a-3p (miR371) has been suggested as a sensitive biomarker in testicular germ cell cancer (TGCC). We aimed to compare miR371 with the classical biomarkers α-fetoprotein (AFP) and β-human chorionic gonadotropin (hCG<sub>β</sub>). Overall, 180 patients were prospectively enrolled in the study, with serum samples collected before and after orchiectomy. We compared the use of digital droplet ... -
M-ficolin: a valuable biomarker to identify leukaemia from juvenile idiopathic arthritis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-22)Objective: Distinction on clinical grounds between acute lymphoblastic leukaemia presenting with arthropathy (ALLarthropathy) and juvenile idiopathic arthritis (JIA) is difficult, as the clinical and paraclinical signs of leukaemia may be vague. The primary aim was to examine the use of lectin complement pathway proteins as markers to differentiate ALLarthropathy from JIA. The secondary aims were ... -
MRI in the Assessment of TMJ-Arthritis in Children with JIA; Repeatability of a Newly Devised Scoring System
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-19)Rationale and Objectives: The temporomandibular joint (TMJ) is commonly involved in children with juvenile idiopathic arthritis. The diagnosis and evaluation of the disease progression is dependent on medical imaging. The precision of this imaging is under debate. SeveralR scoring systems have been proposed but transparent testing of the precision of the constituents of the scoring systems is ... -
Association of iron deficiency with incident cardiovascular diseases and mortality in the general population
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-05)Aims - Although absolute (AID) and functional iron deficiency (FID) are known risk factors for patients with cardiovascular (CV) disease, their relevance for the general population is unknown. The aim was to assess the association between AID/FID with incident CV disease and mortality in the general population.<p> <p>Methods and results - In 12 164 individuals from three European population-based ... -
Incorporating kidney disease measures into cardiovascular risk prediction: Development and validation in 9 million adults from 72 datasets
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-04)Background: Chronic kidney disease (CKD) measures (estimated glomerular filtration rate [eGFR] and albuminuria) are frequently assessed in clinical practice and improve the prediction of incident cardiovascular disease (CVD), yet most major clinical guidelines do not have a standardized approach for incorporating these measures into CVD risk prediction. “CKD Patch” is a validated method to calibrate ... -
Human blood serum proteome changes after 6 hours of sleep deprivation at night
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-09-25)Background: The aim of this study was to discover significantly changed proteins in human blood serum after loss of 6 h sleep at night. Furthermore, to reveal affected biological process- and molecular function categories that might be clinically relevant, by exploring systems biological databases.<p> <p>Methods: Eight females were recruited by volunteer request. Peripheral venous whole blood was ... -
Automated quantitative evaluation of fetal atrioventricular annular plane systolic excursion
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-06-07)Objectives The primary aim of this study was to evaluate the feasibility of automated measurement of fetal atrioventricular (AV) plane displacement (AVPD) over several cardiac cycles using myocardial velocity traces obtained by color tissue Doppler imaging (cTDI). The secondary objectives were to establish reference ranges for AVPD during the second half of normal pregnancy, to assess fetal ... -
Heterogeneous contributions of change in population distribution of body mass index to change in obesity and underweight
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-03-09)From 1985 to 2016, the prevalence of underweight decreased, and that of obesity and severe obesity increased, in most regions, with significant variation in the magnitude of these changes across regions. We investigated how much change in mean body mass index (BMI) explains changes in the prevalence of underweight, obesity, and severe obesity in different regions using data from 2896 population-based ... -
Air Bubbles Activate Complement and Trigger Hemostasis and C3-Dependent Cytokine Release Ex Vivo in Human Whole Blood
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-03)Venous air embolism, which may complicate medical and surgical procedures, activates complement and triggers thromboinflammation. In lepirudin-anticoagulated human whole blood, we examined the effect of air bubbles on complement and its role in thromboinflammation. Whole blood from 16 donors was incubated with air bubbles without or with inhibitors of C3, C5, C5aR1, or CD14. Complement activation, ... -
Positron emission tomography and single photon emission computed tomography imaging of tertiary lymphoid structures during the development of lupus nephritis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-03)Lymphoid neogenesis occurs in tissues targeted by chronic inflammatory processes, such as infection and autoimmunity. In systemic lupus erythematosus (SLE), such structures develop within the kidneys of lupus-prone mice ((NZBXNZW)F1) and are observed in kidney biopsies taken from SLE patients with lupus nephritis (LN). The purpose of this prospective longitudinal animal study was to detect early ... -
Plasma levels of leptin and risk of future incident venous thromboembolism
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-11)Background - Circulating levels of leptin, an adipocyte-derived hormone, are frequently elevated in obesity. Leptin has been reported to upregulate prothrombotic hemostatic factors in vitro and could potentially mediate venous thromboembolism (VTE) risk in obesity. However, whether leptin is associated with VTE remains uncertain.<p> <p>Objective - This article investigates the association between ... -
Risk scores for prediction of 30-day mortality after transcatheter aortic valve implantation: Results from a two-center study in Norway
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-05-06)Objectives: Transcatheter aortic valve implantation (TAVI)-specific risk scores have been developed based on large registry studies. Our aim was to evaluate how both surgical and novel TAVI risk scores performed in predicting all cause 30-day mortality. In addition, we wanted to explore the validity of our own previously developed model in a separate and more recent cohort.<p> <p>Methods: The ... -
Serum Matrix Metalloproteinase 7 and accelerated glomerular filtration rate decline in a general non-diabetic population
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-26)Background. Age-related reduction of glomerular filtration rate (GFR) is a major contributor to the global chronic kidney disease (CKD) epidemic. We investigated whether baseline serum levels of the pro-fibrotic matrix metalloproteinase 2 (MMP2), MMP7 and their inhibitor, tissue inhibitor of metalloproteinase 1 (TIMP1), which mediates fibrosis development in aging animals, were associated with ... -
Associations between cervical dilatation on admission and mode of delivery, a cohort study of Norwegian nulliparous women
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-16)Objective - To investigate associations between cervical dilatation at hospital admission and mode of delivery.<p> <p>Methods - A cohort study with data from a cluster-randomised controlled trial, the Labour Progression Study. The study population of 6511 nulliparous women with a singleton fetus in cephalic presentation with spontaneous onset of labour at term, was divided into two groups: <4 cm ... -
A Nationwide Study of GATA2 Deficiency in Norway-the Majority of Patients Have Undergone Allo-HSCT
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-10)Purpose: GATA2 deficiency is a rare primary immunodeficiency that has become increasingly recognized due to improved molecular diagnostics and clinical awareness. The only cure for GATA2 deficiency is allogeneic hematopoietic stem cell transplantation (allo-HSCT). The inconsistency of genotype-phenotype correlations makes the decision regarding "who and when" to transplant challenging. Despite ...