Institutt for klinisk medisin: Recent submissions
Now showing items 681-700 of 1804
-
D-dimer as a stand-alone test to rule out deep vein thrombosis
(Journal article; Tidsskriftartikkel, 2020-04-25)Background - Current guidelines recommend the use of clinical decision rules, such as Wells score, in combination with D-dimer to assess the need for objective imaging to rule out deep vein thrombosis (DVT). However, the clinical decision rule has limitations, and use of D-dimer as a stand-alone test has been suggested.<p> <p>Objective - We aimed to assess the safety and efficiency of D-dimer as ... -
The fraction of lung cancer attributable to smoking in the Norwegian Women and Cancer (NOWAC) Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-27)<i>Background</i> - We examined the association between active and passive smoking and lung cancer risk and the population attributable fraction (PAF) of lung cancer due to active smoking, in the Norwegian Women and Cancer Study, a nationally representative prospective cohort study.<br><br> <i>Methods</i> - We followed 142,508 women, aged 31–70 years, who completed a baseline questionnaire between ... -
Leisure physical exercise and creatine kinase activity. The Tromsø study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-08-16)Creatine kinase (CK) is an enzyme catalyzing energy reaction in muscle cells and has proven to modify cardiovascular risks. The influence of skeletal muscle activity on CK concentrations is a potential study confounder but is mainly reported in connection with sport activities. This study investigated the association between leisure physical exercise and CK and estimated the effect of physical ... -
Management strategies for children with COVID-19: ESPR practical recommendations
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-03)During the outbreak of the COVID-19 pandemic, guidelines have been issued by international, national and local authorities to address management and the need for preparedness. Children with COVID-19 differ from adults in that they are less often and less severely affected. Additional precautions required in the management of children address their increased radiosensitivity, need for accompanying ... -
BK polyomavirus evades innate immune sensing by disrupting the mitochondrial network and promotes mitophagy
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-10)Immune escape contributes to viral persistence, yet little is known about human polyomaviruses. BK-polyomavirus (BKPyV) asymptomatically infects 90% of humans but causes premature allograft failure in kidney transplant patients. Despite virus-specific T cells and neutralizing antibodies, BKPyV persists in kidneys and evades immune control as evidenced by urinary shedding in immunocompetent individuals. ... -
Metachronous Contralateral Testicular Cancer in the Cisplatin Era: A Population-Based Cohort Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-23)PURPOSE - It is hypothesized that cisplatin-based chemotherapy (CBCT) reduces the occurrence of metachronous contralateral (second) germ cell testicular cancer (TC). However, studies including treatment details are lacking. The aim of this study was to assess the second TC risk, emphasizing the impact of previous TC treatment.<p> <p>PATIENTS AND METHODS - Based on the Cancer Registry of Norway, ... -
Urinary excretion of epidermal growth factor and rapid loss of kidney function
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-17)Background - Lower urinary excretion of the kidney tubule–specific biomarker epidermal growth factor (uEGF) is associated with increased risk of renal function [glomerular filtration rate (GFR)] loss in diabetes and in patients with established chronic kidney disease (CKD). We investigated whether uEGF is associated with rapid GFR decline or incident CKD in the general population.<p> <p>Methods ... -
Machine learning algorithms performed no better than regression models for prognostication in traumatic brain injury
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-03-19)<i>Objective</i> - We aimed to explore the added value of common machine learning (ML) algorithms for prediction of outcome for moderate and severe traumatic brain injury.<br><br> <i>Study Design and Setting</i> - We performed logistic regression (LR), lasso regression, and ridge regression with key baseline predictors in the IMPACT-II database (15 studies, <i>n</i> = 11,022). ML algorithms ... -
User requirements meet large-scale EHR suites: Norwegian preparations for Epic
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020)Electronic health records (EHRs) are becoming the norm in healthcare. Typically, these EHRs are large-scale suite systems. The up-front presence of ready-for-use EHR suites changes the role of user requirements and the conditions for deciding which requirements to include in the final contract. In this paper, we investigate how user requirements are negotiated in the ongoing preparations for the ... -
Repositioning of the global epicentre of non-optimal cholesterol
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-03)High blood cholesterol is typically considered a feature of wealthy western countries1,2. However, dietary and behavioural determinants of blood cholesterol are changing rapidly throughout the world3 and countries are using lipid-lowering medications at varying rates. These changes can have distinct effects on the levels of high-density lipoprotein (HDL) cholesterol and non-HDL cholesterol, which ... -
Prospects for improved glomerular filtration rate estimation based on creatinine-results from a transnational multicentre study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-13)Background - The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) creatinine equation is routinely used to assess renal function but exhibits varying accuracy depending on patient characteristics and clinical presentation. The overall aim of the present study was to assess if and to what extent glomerular filtration rate (GFR) estimation based on creatinine can be improved.<p> <p>Methods ... -
Combined effects of five prothrombotic genotypes and cancer on the risk of a first venous thromboembolic event
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-16)Background - The role of combined prothrombotic genotypes in cancer‐related venous thromboembolism (VTE) is scarcely studied. We aimed to investigate the impact of a 5‐single nucleotide polymorphism (SNP) score on the risk of VTE in patients with and without cancer using a population‐based case‐cohort.<p> <p>Methods - Cases with a first VTE (n = 1493) and a subcohort (n = 13 072) were derived ... -
Performance of Expanded Newborn Screening in Norway Supported by Post-Analytical Bioinformatics Tools and Rapid Second-Tier DNA Analyses
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-27)In 2012, the Norwegian newborn screening program (NBS) was expanded (eNBS) from screening for two diseases to that for 23 diseases (20 inborn errors of metabolism, IEMs) and again in 2018, to include a total of 25 conditions (21 IEMs). Between 1 March 2012 and 29 February 2020, 461,369 newborns were screened for 20 IEMs in addition to phenylketonuria (PKU). Excluding PKU, there were 75 true-positive ... -
Reinnleggelser ved en hjertemedisinsk avdeling
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-13)<i>BAKGRUNN</i> - Reinnleggelse av pasienter kan være uttrykk for uhensiktsmessige pasientforløp eller kvalitetssvikt. Formålet med studien var å se om vi kunne identifisere områder for forbedring ved å gjennomgå 50 ikke-planlagte reinnleggelser.<p> <p><i>MATERIALE OG METODE</i> - Vi gjennomgikk 50 fortløpende ikke-planlagte reinnleggelser ved Hjertemedisinsk avdeling ved Universitetssykehuset ... -
Confirmatory analysis of QUARTZ study results: Survival prolongation after whole-brain radiotherapy
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-02-03)<p>Background/Aim: The aim of this study was to analyze the survival of patients with brain metastases treated with best supportive care or additional whole-brain radiotherapy (WBRT), in order to confirm results from the prospective randomized QUARTZ study, which suggested prolonged survival after WBRT (5 fractions of 4 Gy) if favorable prognostic factors were present (age younger than 60 years, ... -
Symptom burden in patients with reduced performance status at the start of palliative radiotherapy
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-02-28)<p>Background/Aim: Previous research has suggested that palliative radiotherapy is a useful measure, unless short survival reduces the time spent without active treatment, and in the case of a low likelihood of experiencing a net benefit in quality of life. Patients with reduced performance status (PS) may be especially at risk of futile treatment, despite having a relatively high symptom burden and ... -
Pain During Sex Before and After Surgery for Lumbar Disc Herniation - A Multicenter Observational Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-15)<p>Study Design. Observational multicenter study. <p>Objective. The aim of this study was to evaluate changes in pain during sexual activity after surgery for lumbar disc herniation (LDH). <p>Summary of Background Data. There are limited data available on sexual function in patients undergoing surgery for LDH. <p>Methods. Data were retrieved from the Norwegian Registry for Spine Surgery. The ... -
What does hand motor function tell us about our aging brain in association with WMH?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-08-29)<i>Background</i> - White matter hyperintensities (WMH) are a common cerebral finding in older people. WMH are usually asymptomatic, but excessive WMH are associated with cognitive decline and dementia. WMH are also among the neurological findings most consistently associated with declining motor performance in healthy ageing.<br><br> <i>Aims</i> - To determine if WMH load is associated with ... -
Non-Homologous End Joining Factors XLF, PAXX and DNA-PKcs Maintain the Neural Stem and Progenitor Cell Population
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-28)Non-homologous end-joining (NHEJ) is a major DNA repair pathway in mammalian cells that recognizes, processes and fixes DNA damage throughout the cell cycle and is specifically important for homeostasis of post-mitotic neurons and developing lymphocytes. Neuronal apoptosis increases in the mice lacking NHEJ factors Ku70 and Ku80. Inactivation of other NHEJ genes, either <i>Xrcc4</i> or <i>Lig4</i>, ... -
Sars-CoV-2 hos barn og ungdom i Norge: Påvist smitte, sykehusinnleggelser og underliggende tilstander
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-24)BAKGRUNN - Barn og unge har lavere risiko for sykdom forårsaket av sars-CoV-2. Vi beskriver forekomsten av påvist smitte og innleggelser hos barn og unge under 20 år i Norge, og spesifikt blant dem med underliggende tilstander.<p> <p>MATERIALE OG METODE - Helsedirektoratet har i samarbeid med Folkehelseinstituttet etablert et datauttrekk for å overvåke koronavirusutbruddet. Data fra ...