Institutt for klinisk medisin: Nye registreringer

Viser treff 121-140 av 1974

    • Umbilical Cord pH Levels and Neonatal Morbidity and Mortality 

      Andersson, Charlotte Brix; Klingenberg, Claus Andreas; Thellesen, Line; Johnsen, Søren Paaske; Kesmodel, Ulrik Schiøler; Petersen, Jesper Padkaer (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-08-14)
      Importance Umbilical cord pH (UC-pH) level is an important objective indicator of intrapartum fetal hypoxia and is used to predict neonatal morbidity and mortality. A UC-pH value of less than 7.00 is often defined as a threshold for severe acidosis, but existing evidence is divergent and largely based on UC-pH measurements from selected populations; consequently, the results are challenging to ...

    • Extracellular vesicles from activated platelets possess a phospholipid-rich biomolecular profile and enhance prothrombinase activity 

      Mazagao Guerreiro, Eduarda; Kruglik, Sergei G.; Swamy, Samantha; Latysheva, Nadezhda; Østerud, Bjarne; Guigner, Jean-Michel; Sureau, Franck; Bonneau, Stephanie; Kuzmin, Andrey N.; Prasad, Paras N.; Hansen, John Bjarne; Hellesø, Olav Gaute; Snir, Omri (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-01-22)
      Background: Extracellular vesicles (EVs), in particular those derived from activated platelets, are associated with a risk of future venous thromboembolism. Objectives: To study the biomolecular profile and function characteristics of EVs from control (unstimulated) and activated platelets.<p> <p>Methods: Biomolecular profiling of single or very few (1-4) platelet-EVs (control/ stimulated) was ...

    • Performance of an Artificial Intelligence System for Breast Cancer Detection on Screening Mammograms from BreastScreen Norway 

      Larsen, Marthe; Olstad, Camilla Flåt; Lee, Christoph I.; Hovda, Tone; Hoff, Solveig Kristin Roth; Martiniussen, Marit Almenning; Mikalsen, Karl Øyvind; Lund-Hanssen, Håkon; Solli, Helene; Silberhorn, Marko; Sulheim, Åse Ø.; Auensen, Steinar Gøytil; Nygård, Jan Franz; Hofvind, Solveig Sand-Hanssen (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-04-10)
      A commercially available artificial intelligence system showed high performance in detecting breast cancers within 2 years of screening mammography and may help triage low-risk mammograms to reduce radiologist workload.<p> <p>Purpose - To explore the stand-alone breast cancer detection performance, at different risk score thresholds, of a commercially available artificial intelligence (AI) ...

    • Neutrophil Extracellular Traps in ST-Segment Elevation Myocardial Infarction: Reduced by Tocilizumab and Associated With Infarct Size 

      Kindberg, Kristine Mørk; Broch, Kaspar; Andersen, Geir Øystein; Anstensrud, Anne Kristine; Åkra, Sissel; Woxholt, Sindre; Tøllefsen, Ingvild Maria; Ueland, Thor; Amundsen, Brage H.; Kløw, Nils-Einar; Halvorsen, Bente; Dahl, Tuva Børresdatter; Huse, Camilla; Murphy, Sarah Louise Mikalsen; Damås, Jan Kristian; Opdahl, Anders; Wiseth, Rune; Gullestad, Lars; Aukrust, Pål; Santos-Gallego, Carlos; Seljeflot, Ingebjørg; Stokke, Mathis Korseberg; Helseth, Ragnhild Merckoll (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-08-15)
      Background - Interleukin-6-receptor inhibition with tocilizumab improves myocardial salvage in patients with ST-segment elevation myocardial infarction (STEMI). Reduced levels of neutrophil extracellular traps (NETs), which consist of nuclear material studded with proteins released upon neutrophil activation, might contribute to this effect.<p> <p>Objectives - The purpose of this study was to ...

    • Patient-reported symptoms before adjuvant locoregional radiotherapy for breast cancer: triple-negative histology impacts the symptom burden 

      Nieder, Carsten; Johnsen, Silje Kristine; Winther, Annette M.; Mannsåker, Bård (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-03-26)
      Background Multimodal breast cancer treatment may cause side effects reflected in patient-reported outcomes and/or symptom scores at the time of treatment planning for adjuvant radiotherapy. In our department, all patients have been assessed with the Edmonton Symptom Assessment System (ESAS; a questionnaire addressing 11 major symptoms and wellbeing on a numeric scale of 0–10) at the time of ...

    • Effect of a low-carbohydrate diet on pain and quality of life in female patients with lipedema: a randomized controlled trial 

      Lundanes, Julianne; Sandnes, Frida Huhta; Gjeilo, Kari Hanne; Salater, Sissel; Alho Letra Martins, Catia Patricia; Nymo, Siren; Hanson, Patrik (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-04-16)
      Objective: The primary objective of this study was to evaluate the effect of a low-carbohydrate diet (LCD) compared with a control diet on pain in female patients with lipedema. The secondary objectives were to compare the impact of the two diets on quality of life (QoL) and investigate potential associations of changes in pain with changes in body weight, body composition, and ketosis.<p> <p>Methods: ...

    • Tumor versus Tumor Cell Targeting in Metal-Based Nanoparticles for Cancer Theranostics 

      Urbano-Gámez, Jesús David; Guzzi, Cinzia; Bernal, Manuel; Solivera, Juan; Martinez, Inigo Zubiavrre; Caro, Carlos; García-Martín, María Luisa (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-05-10)
      The application of metal-based nanoparticles (mNPs) in cancer therapy and diagnostics (theranostics) has been a hot research topic since the early days of nanotechnology, becoming even more relevant in recent years. However, the clinical translation of this technology has been notably poor, with one of the main reasons being a lack of understanding of the disease and conceptual errors in the design ...

    • Free Vascularized Fibula Graft as Primary Salvage Procedure for Acute Cervical Osteomyelitis Caused by Epidural Abscess 

      Ciosek, Timothy Allan; Sørlie, Andreas; Munch-Ellingsen, Jens; Solberg, Tore; Weum, Sven Magne; Weerd, Louis de (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-05-24)
      Acute cervical osteomyelitis due to an epidural abscess and pyogenic spondylodiscitis in an immunosuppressed patient with progressive myelopathy is a challenge for the reconstructive surgeon. This report presents our novel approach to treat such a condition in a 56-year-old patient in whom antibiotic treatment and decompression of the medulla by laminectomy of C4–C6 failed. Under general anesthesia, ...

    • The prognostic importance of traumatic axonal injury on early MRI: the Trondheim TAI-MRI grading and quantitative models 

      Moen, Kent Gøran; Flusund, Anne-Mari Holte; Moe, Hans Kristian; Andelic, Nada; Skandsen, Toril; Håberg, Asta; Kvistad, Kjell Arne; Olsen, Øystein E.; Saksvoll, Elin Hildrum; Abel-Grüner, Sebastian; Anke, Audny Gabriele Wagner; Follestad, Turid; Vik, Anne (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-06-19)
      Objectives We analysed magnetic resonance imaging (MRI) findings after traumatic brain injury (TBI) aiming to improve the grading of traumatic axonal injury (TAI) to better reflect the outcome.<p> <p>Methods Four-hundred sixty-three patients (8–70 years) with mild (n = 158), moderate (n = 129), or severe (n = 176) TBI and early MRI were prospectively included. TAI presence, numbers, and volumes ...

    • Status epilepticus in POLG disease: a large multinational study 

      Hikmat, Omar; Naess, Karin; Engvall, Martin; Klingenberg, Claus Andreas; Rasmussen, Magnhild; Brodtkorb, Eylert; Ostergaard, Elsebet; de Coo, Irenaeus; Pias-Peleteiro, Leticia; Isohanni, Pirjo; Uusimaa, Johanna; Majamaa, Kari; Kärppä, Mikko; Ortigoza-Escobar, Juan Dario; Tangeraas, Trine; Berland, Siren; Harrison, Emma; Biggs, Heather; Horvath, Rita; Darin, Niklas; Rahman, Shamima; Bindoff, Laurence Albert (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-06-01)
      We aimed to provide a detailed phenotypic description of status epilepticus (SE) in a large cohort of patients with POLG disease and identify prognostic biomarkers to improve the management of this life-threatening condition. In a multinational, retrospective study with data on patients with POLG disease from seven European countries, we identified those who had SE. The age of SE onset, accompanying ...

    • Plugging of pipes by cohesive particles. Computed tomography investigation and theoretical analysis 

      Balakin, Boris; Chang, Yu-Fen; Øynes, Mona; Struchalin, Pavel (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-05-09)
      Flow regimes leading to clogging of pipes exist for most multiphase flows with cohesive particles. Although plugging is critical in many industrial and medical applications, there are few records describing the details of the process. To address the problem, we conduct a computed tomography (CT) study of plugging in a cohesive ice slurry. We run experiments for ice concentration of 15%, Re∼3500, ...

    • Transdiagnostic Associations between Anger Hostility and Chemokine Interferon-gamma Inducible Protein 10 

      Soløy-Nilsen, Hedda; Nygaard-Odeh, Kristin; Kristiansen, Magnhild Gangsøy; Kvig, Erling Inge; Brekke, Ole Lars; Mollnes, Tom Eirik; Berk, Michael; Reitan, Solveig Klæbo; Øiesvold, Terje (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-17)
      Objective: Many psychiatric disorders are linked to low grade systemic inflammation as measured by systemic cytokine levels. Exploration of cytokines and immune activity and their role in psychiatric symptoms may inform pathobiology and treatment opportunities. The aim of this study is to explore if there are associations between cytokines and psychiatric symptom clusters. Comparison between patients ...

    • Botulinum Toxin A and B for Palmoplantar Hyperhidrosis 

      Eilertsen, Trond; Kvammen, Bjørn Øivind; Grimstad, Øystein (Journal article; Tidsskriftartikkel, 2024-03-01)
      Introduction - Hyperhidrosis is characterized by unpredictable, uncontrollable and excessive sweating. It occurs at rest and is not related to temperature. Hyperhidrosis is a common disorder that has a negative impact on quality of life (QoL). The aim of this quality assurance study was to investigate how treatment of palmoplantar hyperhidrosis with botulinum toxin A (BTX-A) and botulinum toxin B ...

    • Comparative Effectiveness and Persistence of SB4 and Reference Etanercept in Patients With Psoriatic Arthritis in Norway 

      Łosińska, Katarzyna Weronika; Pripp, Are Hugo; Bakland, Gunnstein; Fevang, Bjørg Tilde Svanes; Brekke, Lene Kristin; Wierød, Ada; Korkosz, Mariusz; Haugeberg, Glenn (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-04-10)
      Objective - We aim to compare drug effectiveness and persistence between the reference etanercept (ETN) and ETN biosimilar SB4 in patients with psoriatic arthritis (PsA) naive to ETN and to investigate drug effectiveness and persistence in those undergoing a mandatory nonmedical switch from ETN to SB4.<p> <p>Methods - We used a retrospective comparative database study including 1,138 patients ...

    • The epidemiology of major depression among adults in Norway: an observational study on the concurrence between population surveys and registry data – a NCDNOR project 

      Bramness, Jørgen Gustav; Hjellvik, Vidar; Høye, Anne; Tesli, Martin Steen; Haram, Marit; Nystad, Wenche; Krokstad, Steinar (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-05-17)
      Background Mental health problems, and major depression in particular, are important public health issues. Following trends in the prevalence of major depression is difficult because of the costs and complications of diagnostic interviews and general population self-report health surveys. Scandinavian countries, however, have several central, population-based health registries. We aimed to ...

    • Epidemiology and natural history of POLG disease in Norway: a nationwide cohort study 

      Kristensen, Erle; Mathisen, Linda; Berland, Siren; Klingenberg, Claus Andreas; Brodtkorb, Eylert; Rasmussen, Magnhild; Tangeraas, Trine; Bliksrud, Yngve Thomas; Rahman, Shamima; Bindoff, Laurence Albert; Hikmat, Omar (Journal article; Tidsskriftartikkel, 2024-06-07)
      <p><i>Objective</i> To investigate the prevalence and natural history of POLG disease in the Norwegian population. <p><i>Methods</i> A national, population-based, retrospective study using demographic, clinical, and genetic data of patients with genetically confirmed POLG disease. The patients were diagnosed between 2002 and 2022, and were included into the Norwegian POLG Patient Registry. Patients ...

    • Primary Retroperitoneal Lymph Node Dissection as Treatment for Low-volume Metastatic Seminoma in a Population-based Cohort: The Swedish Norwegian Testicular Cancer Group Experience 

      Thor, Anna; Negaard, Helene Francisca Stigter; Grenabo Bergdahl, Anna; Almås, Bjarte; Larsen, Signe Melsen; Lundgren, Per-Olof; Gerdtsson, Axel; Halvorsen, Dag; Johannsdottir, Berglind; Jansson, Anna K.; Hellström, Martin; Wahlqvist, Rolf; Langberg, Carl W.; Hedlund, Annika; Akre, Olof; Glimelius, Ingrid; Ståhl, Olof; Haugnes, Hege Sagstuen; Cohn-Cedermark, Gabriella; Kjellman, Anders; Tandstad, Torgrim (Journal article; Tidsskriftartikkel, 2024-06-11)
      <p><i>Background and objective</i> There is an unmet need to avoid long-term morbidity associated with standard cytotoxic treatment for low-volume metastatic seminoma. Our aim was to assess the oncological efficacy and surgical safety of retroperitoneal lymph node dissection (RPLND) as treatment in a population-based cohort of metastatic seminoma patients with limited retroperitoneal lymphadenopat ...

    • Body weight and composition endpoints in cancer cachexia clinical trials: Systematic Review 4 of the cachexia endpoints series 

      Brown, Leo R.; Sousa, Mariana S.; Yule, Michael S.; Baracos, Vickie E.; McMillan, Donald C.; Arends, Jann; Balstad, Trude Rakel; Bye, Asta; Dajani, Olav; Dolan, Ross D.; Fallon, Marie T.; Greil, Christine; Hjermstad, Marianne Jensen; Jakobsen, Gunnhild; Maddocks, Matthew; McDonald, James; Ottestad, Inger; Phillips, Iain; Sayers, Judith; Simpson, Melanie Rae; Vagnildhaug, Ola Magne; Solheim, Tora S; Laird, Barry J; Skipworth, Richard J.E. (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-05-13)
      Significant variation exists in the outcomes used in cancer cachexia trials, including measures of body composition, which are often selected as primary or secondary endpoints. To date, there has been no review of the most commonly selected measures or their potential sensitivity to detect changes resulting from the interventions being examined. The aim of this systematic review is to assess the ...

    • Targeted temperature control following traumatic brain injury: ESICM/NACCS best practice consensus recommendations 

      Lavinio, Andrea; Coles, Jonathan P.; Robba, Chiara; Aries, Marcel; Bouzat, Pierre; Chean, Dara; K Frisvold, Shirin; Galarza, Laura; Helbok, Raimund; Hermanides, Jeroen; van der Jagt, Mathieu; Menon, David K.; Meyfroidt, Geert; Payen, Jean-Francois; Poole, Daniele; Rasulo, Frank; Rhodes, Jonathan; Sidlow, Emily; Steiner, Luzius A.; Taccone, Fabio Silvio; Takala, Riikka (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-05-20)
      Aims and scope The aim of this panel was to develop consensus recommendations on targeted temperature control (TTC) in patients with severe traumatic brain injury (TBI) and in patients with moderate TBI who deteriorate and require admission to the intensive care unit for intracranial pressure (ICP) management.<p> <p>Methods A group of 18 international neuro-intensive care experts in the acute ...

    • Biomarker endpoints in cancer cachexia clinical trials: Systematic Review 5 of the cachexia endpoint series 

      Yule, Michael S.; Thompson, Joshua; Leesahatsawat, Khachonphat; Sousa, Mariana S.; Anker, Stefan D.; Arends, Jann; Balstad, Trude Rakel; Brown, Leo R.; Bye, Asta; Dajani, Olav; Fallon, Marie; Hjermstad, Marianne Jensen; Jakobsen, Gunnhild; McDonald, James; McGovern, Josh; Roeland, Eric J.; Sayers, Judith; Skipworth, Richard J.E.; Ottestad, Inger; Philips, Iain; Simpson, Melanie Rae; Solheim, Tora S; Vagnildhaug, Ola Magne; McMillan, Donald; Laird, Barry J; Dolan, Ross D. (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-05-23)
      Regulatory agencies require evidence that endpoints correlate with clinical benefit before they can be used to approve drugs. Biomarkers are often considered surrogate endpoints. In cancer cachexia trials, the measurement of biomarkers features frequently. The aim of this systematic review was to assess the frequency and diversity of biomarker endpoints in cancer cachexia trials. A comprehensive ...