English
norskInstitutt for klinisk medisin: Nye registreringer
Viser treff 1781-1800 av 1974
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Optimal sleep duration in the subarctic with respect to obesity risk is 8-9 hours
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)Sleep duration, chronotype and social jetlag have been associated with body mass index (BMI) and abdominal obesity. The optimal sleep duration regarding BMI has previously been found to be 7–8 hours, but these studies have not been carried out in the subarctic or have lacked some central variables. The aims of our study were to examine the associations between sleep variables and body composition ... -
Long-term efficacy and safety of pre-emptive maintenance therapy with rituximab in Granulomatosis with Polyangiitis: results from a single centre.
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)Rituximab (RTX) is an anti-CD20 antibody used successfully in granulomatosis with polyangiitis (GPA) for induction and maintenance of remission. Our study aims to evaluate the long-term efficacy and safety of chronic pre-emptive RTX therapy in GPA. Retrospective study of 35 GPA patients treated with RTX between April 2004 and September 2011 for active disease and maintenance. RTX was initiated as ... -
Cyclophosphamide effect on immunoglobulins levels in AAV patients treated with long-term pre-emptive rituximab maintenance.
(Conference object; Konferansebidrag, 2013) -
Prognostic impact of Skp2, ER and PGR in male and female patients with soft tissue sarcomas
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)BACKGROUND: S-phase kinase-associated protein 2 (Skp2) is a member of mammalian F-box proteins. The purpose of this study is to clarify the prognostic significance of expression of Skp2 related to gender, estrogen receptor (ER) and progesterone receptor (PGR) in soft tissue sarcomas (STS). Optimized treatment of STS requires better identification of high-risk patients who will benefit from adjuvant ... -
Electronic Symptom Reporting Between Patient and Provider for Improved Health Care Service Quality: A Systematic Review of Randomized Controlled Trials. Part 1: State of the Art
(Journal article; Tidsskriftartikkel; Peer reviewed, 2012)Background: Over the last two decades, the number of studies on electronic symptom reporting has increased greatly. However, the field is very heterogeneous: the choices of patient groups, health service innovations, and research targets seem to involve a broad range of foci. To move the field forward, it is necessary to build on work that has been done and direct further research to the areas holding ... -
Cystatin C is associated with risk of venous thromboembolism in subjects with normal kidney function - the Tromso study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2012)Background Previous studies have shown an association between impaired kidney function, assessed by cystatin C-based estimated glomerular filtration rate, and venous thromboembolism. The aim of this study was to investigate whether serum cystatin C was associated with a risk of venous thromboembolism among subjects with normal kidney function in a prospective population-based study. Design and ... -
Trauma Care in Africa: A Status Report From Botswana, Guided by the World Health Organization's "Guidelines for Essential Trauma Care"
(Journal article; Tidsskriftartikkel; Peer reviewed, 2012) -
Diagnosing comorbidity in psychiatric hospital:challenging the validity of administrative registers
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)Background This study will explore the validity of psychiatric diagnoses in administrative registers with special emphasis on comorbid anxiety and substance use disorders. Methods All new patients admitted to psychiatric hospital in northern Norway during one year were asked to participate. Of 477 patients found eligible, 272 gave their informed consent. 250 patients (52%) with hospital ... -
Episiotomy characteristics and risks for obstetric anal sphincter injuries: a case-control study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2012)Objectives To investigate the association between the geometrical properties of episiotomy and obstetric anal sphincter injuries (OASIS) because episiotomies angled at 40–60° are associated with fewer OASIS than episiotomies with more acute angles. Design Case–control study. Setting University Hospital of North Norway, Tromsø and Nordland Hospital, Bodø, Norway. Sample Seventy-four women ... -
Using Noninferiority Tests to Evaluate Telemedicine and E-Health Services: Systematic Review
(Journal article; Tidsskriftartikkel; Peer reviewed, 2012)Background: An increasing number of studies within the field of telemedicine and e-health are designed as noninferiority studies, aiming to show that the telemedicine/e-health solution is not inferior to the traditional way of treating patients. Objective: The objective is to review and sum up the status of noninferiority studies within this field, describing advantages and pitfalls of this approach. ... -
Electronic Symptom Reporting Between Patient and Provider for Improved Health Care Service Quality: A Systematic Review of Randomized Controlled Trials. Part 2: Methodological Quality and Effects
(Tidsskriftartikkel; Journal article; Peer reviewed, 2012)Background: We conducted in two parts a systematic review of randomized controlled trials (RCTs) on electronic symptom reporting between patients and providers to improve health care service quality. Part 1 reviewed the typology of patient groups, health service innovations, and research targets. Four innovation categories were identified: consultation support, monitoring with clinician support, ... -
Suicidality related to first-time admissions to psychiatric hospital
(Journal article; Tidsskriftartikkel; Peer reviewed, 2012)The epidemiology of suicidality shows considerable variation across sites. However, one of the strongest predictors of suicide is a suicidal attempt. Knowledge of the epidemiology of suicidal ideas and attempts in the general population as well as in the health care system is of importance for designing preventive strategies. In this study, we will explore the role of the psychiatric hospital in ... -
Towards Improved Prognostic Scores Predicting Survival in Patients with Brain Metastases: A Pilot Study of Serum Lactate Dehydrogenase Levels
(Journal article; Tidsskriftartikkel; Peer reviewed, 2012)Accurate prognostic information is desirable when counselling patients with brain metastases regarding their therapeutic options and life expectancy. Based on previous studies, we selected serum lactate dehydrogenase (LDH) as a promising factor on which we perform a pilot study investigating methodological aspects of biomarker studies in patients with brain metastases, before embarking on large-scale ... -
Contribution of Case Reports to Brain Metastases Research: Systematic Review and Analysis of Pattern of Citation
(Journal article; Tidsskriftartikkel; Peer reviewed, 2012)Research activity related to different aspects of prevention, prediction, diagnosis and treatment of brain metastases has increased during recent years. One of the major databases (Scopus) contains 942 scientific articles that were published during the 5-year time period 2006–2010. Of these, 195 (21%) reported on single patient cases and 12 (1%) were reports of 2 cases. Little is known about their ... -
Brain Metastases Research 1990-2010: Pattern of Citation and Systematic Review of Highly Cited Articles
(Journal article; Tidsskriftartikkel; Peer reviewed, 2012)High and continuously increasing research activity related to different aspects of prevention, prediction, diagnosis and treatment of brain metastases has been performed between 1990 and 2010. One of the major databases contains 2695 scientific articles that were published during this time period. Different measures of impact, visibility, and quality of published research are available, each with ... -
Hypothermic cardiac arrest far away from the center providing rewarming with extracorporeal circulation.
(Journal article; Tidsskriftartikkel; Peer reviewed, 2012)A 41-year-old man suffered hypothermic cardiac arrest after water immersion and was transported to our university hospital by ambulance helicopter for rewarming on cardiopulmonary bypass. He resumed spontaneous cardiac activity 6 h 52 min after cardiac arrest and recovered completely. -
Comparison of Goal-Directed Hemodynamic Optimization using Pulmonary Artery Catheter and Transpulmonary Thermodilution in Combined Valve Repair: A Randomized Clinical Trial
(Journal article; Tidsskriftartikkel; Peer reviewed, 2012)Our aim was to compare the effects of goal-directed therapy guided either by pulmonary artery catheter (PAC) or by transpulmonary thermodilution (TTD) combined with monitoring of oxygen transport on perioperative hemodynamics and outcome after complex elective valve surgery. Measurements and Main Results. Forty patients were randomized into two equal groups: a PAC group and a TTD group. In the ... -
Incidence of obstetric anal sphincter injuries after training to protect the perineum: cohort study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2012)Objective To compare the incidence of obstetric anal sphincter injuries (OASIS) in two time periods, before and after implementing a training programme for improved perineal support aimed at reducing the incidence of obstetric anal sphincter injuries. The secondary aim was to study incidence of obstetric anal sphincter injuries in subgroups defined by risk factors for OASIS. Design Population-based ... -
Polymorphisms Related to the Serum 25-Hydroxyvitamin D Level and Risk of Myocardial Infarction, Diabetes, Cancer and Mortality. The Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2012)Low serum 25(OH)D levels are associated with cardiovascular risk factors, and also predict future myocardial infarction (MI), type 2 diabetes (T2DM), cancer and all-cause mortality. Recently several single nucleotide polymorphisms (SNPs) associated with serum 25-hydroxyvitamin D (25(OH)D) level have been identified. If these relations are causal one would expect a similar association between these ... -
Cancer-associated fibroblasts from human NSCLC survive ablative doses of radiation but their invasive capacity is reduced
(Journal article; Tidsskriftartikkel; Peer reviewed, 2012)BACKGROUND: Cancer-Associated Fibroblasts (CAFs) are significant components of solid malignancies and play central roles in cancer sustainability, invasion and metastasis. In this study we have investigated the invasive capacity and matrix remodelling properties of human lung CAFs after exposure to ablative doses of ionizing radiation (AIR), equivalent to single fractions delivered by stereotactic ...
