Institutt for klinisk medisin: Nye registreringer

Viser treff 1841-1860 av 1974

    • Rat liver sinusoidal endothelial cells (LSECs) express functional low density lipoprotein receptor-related protein-1 (LRP-1) 

      Øie, Cristina Ionica; Appa, Rupa Shree; Hilden, Ida; Petersen, Helle Heibroch; Gruhler, Albrecht; Smedsrød, Bård; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      The low density lipoprotein receptor-related protein-1 (LRP-1) is a large, multifunctional endocytic receptor from the LDL receptor family, highly expressed in liver parenchymal cells (PCs), neurons, activated astrocytes, and fibroblasts. The aim of the study was to investigate if liver sinusoidal endothelial cells (LSECs), highly specialized scavenger cells, express LRP-1. To address this question, ...

    • Independent and Tissue-Specific Prognostic Impact of miR-126 in Nonsmall Cell Lung Cancer 

      Dønnem, Tom; Lønvik, Kenneth; Eklo, Katrine; Berg, Thomas; Sørbye, Sveinung Wergeland; Al-Shibli, Khalid Ibrahim; Al-Saad, Samer; Andersen, Sigve; Stenvold, Helge; Bremnes, Roy M.; Busund, Lill-Tove (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Angiogenesis is pivotal in tumor development. Vascular endothelial growth factor-A (VEGF-A) is considered one of the most important angiogenic factors, but lately several microRNAs (miRs) have been associated with vascular development. miR-126 has been related to tumor angiogenesis and in the regulation of VEGF-A. The authors aimed to investigate the prognostic impact of miR-126 and its co-expression ...

    • Home mechanical ventilation and specialised health care in the community : between a rock and a hard place 

      Dybwik, Knut; Nielsen, Erik Waage; Brinchmann, Berit Støre (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Home mechanical ventilation probably represents the most advanced and complicated type of medical treatment provisioned outside a hospital setting. The aim of this study was both to explore the challenges experienced by health care professionals in community health care services when caring for patients dependent on home mechanical ventilation, continual care and highly advanced technology, and their ...

    • A rapid chemokine response of macrophage inflammatory protein (MIP)-1 alpha, MIP-1 beta and the regulated on activation, normal T expressed and secreted chemokine is associated with a sustained virological response in the treatment of chronic hepatitis C 

      Florholmen, Jon; Kristiansen, Magnhild Gangsøy; Steigen, sonja eriksson; Sørbye, Sveinung Wergeland; Paulssen, Eyvind Jakob; Kvamme, J.M.; Zbigniew, Konopski; Gutteberg, tore jarl; Goll, Rasmus (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      The role of chemokines in chronic hepatitis C virus (HCV) infection is not fully understood. The present study aimed to characterize the baseline serum concentrations and the initial β-chemokine response to treatment with interferon-α and ribavirin with respect to the final clinical outcome of virological response to treatment. Serum concentrations of alanine aminotransferase (ALT) and of the CC ...

    • Three-dimensional ultrasonic imaging in multilayered media 

      Skjelvareid, Martin Hansen; Olofsson, Tomas; Birkelund, Yngve (Conference object; Konferansebidrag, 2011)
      The synthetic aperture focusing technique is a method for focusing ultrasonic scans used in nondestructive testing. Traditionally, the technique has mainly been used for contact testing, where the speed of sound is constant throughout the whole medium, but a number of recently proposed algorithms have extended the technique to multilayered media. One important application for such multilayer methods ...

    • Predictive and Prognostic Impact of TP53 Mutations and MDM2 Promoter Genotype in Primary Breast Cancer Patients Treated with Epirubicin or Paclitaxel 

      Chrisanthar, Ranjan; Knappskog, Stian; Løkkevik, Erik; Anker, Gun Birgitta; Østenstad, Bjørn; Lundgren, Steinar; Risberg, Terje; Mjaaland, Ingvil; Skjønsberg, Gudbrand; Aas, Turid; Schlichting, Ellen; Fjøsne, Hans Erikssønn; Nysted, Arne; Lillehaug, Johan R.; Lønning, Per Eystein (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      TP53 mutations have been associated with resistance to anthracyclines but not to taxanes in breast cancer patients. The MDM2 promoter single nucleotide polymorphism (SNP) T309G increases MDM2 activity and may reduce wildtype p53 protein activity. Here, we explored the predictive and prognostic value of TP53 and CHEK2 mutation status together with MDM2 SNP309 genotype in stage III breast cancer ...

    • Overexpression of the HIF Hydroxylases PHD1, PHD2, PHD3 and FIH Are Individually and Collectively Unfavorable Prognosticators for NSCLC Survival 

      Andersen, Sigve; Dønnem, Tom; Stenvold, Helge; Al-Saad, Samer; Al-Shibli, Khalid Ibrahim; Busund, Lill-Tove; Bremnes, Roy M. (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Hypoxia induced factors (HIFs) are at the heart of the adaptive mechanisms cancer cells must implement for survival. HIFs are regulated by four hydroxylases; Prolyl hydroxylase (PHD)-1,-2,-3 and factor inhibiting HIF (FIH). We aimed to investigate the prognostic impact of these oxygen sensors in NSCLC. Tumor tissue samples from 335 resected stages I to IIIA NSCLC patients was obtained and tissue ...

    • Fukutin-Related Protein Resides in the Golgi Cisternae of Skeletal Muscle Fibres and Forms Disulfide-Linked Homodimers via an N-Terminal Interaction 

      Alhamidi, Maisoon; Kjeldsen, Elisabeth; Fagerheim, Toril; Brox, Vigdis; Lindal, Sigurd; Van Ghelue, Marijke; Nilssen, Øivind (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Limb-Girdle Muscular Dystrophy type 2I (LGMD2I) is an inheritable autosomal, recessive disorder caused by mutations in the FuKutin-Related Protein (FKRP) gene (FKRP) located on chromosome 19 (19q13.3). Mutations in FKRP are also associated with Congenital Muscular Dystrophy (MDC1C), Walker-Warburg Syndrome (WWS) and Muscle Eye Brain disease (MEB). These four disorders share in common an incomplete/aberrant ...

    • Norwegian trauma team leaders - training and experience : a national point prevalence study 

      Ringen, Amund Hovengen; Hjortdahl, Magnus; Wisborg, Torben (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      The treatment of trauma victims is a complex multi-professional task in a stressful environment. We previously found that trauma team members perceive leadership as the most important human factor. The aim of the present study was to assess the experience and education of Norwegian trauma team leaders, and allow them to describe their perceived educational needs. We conducted an anonymous descriptive ...

    • Retro-trochanteric sciatica-like pain : current concept 

      Meknas, Khaled; Johansen, Oddmund; Kartus, Jüri (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      The aim of this manuscript is to review the current knowledge in terms of retro-trochanteric pain syndrome, make recommendations for diagnosis and differential diagnosis and offer suggestions for treatment options. The terminology in the literature is confusing and these symptoms can be referred to as ‘greater trochanteric pain syndrome’, ‘trochanteric bursitis’ and ‘trochanteritis’, among other ...

    • Cartilage Repair and Joint Preservation Medical and Surgical Treatment Options 

      Madry, Henning; Grün, Ulrich Wolfgang; Knutsen, Gunnar (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Articular cartilage defects are most often caused by trauma and osteoarthritis and less commonly by metabolic disorders of the subchondral bone, such as osteonecrosis and osteochondritis dissecans. Such defects do not heal spontaneously in adults and can lead to secondary osteoarthritis. Medications are indicated for symptomatic relief. Slow-acting drugs in osteo - arthritis (SADOA), such as ...

    • The apolipoprotein C-I content of very-low-density lipoproteins is associated with fasting triglycerides, postprandial lipemia, and carotid atherosclerosis 

      Hansen, John-Bjarne; Fernandes, Jose A.; Notø, Ann-Trude With; Degushi, Hiroshi; Bjørkegren, Johan; Mathiesen, Ellisiv B. (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Experimental studies in animals suggest that apolipoprotein (apo) C-I is an important regulator of triglycerides in fasting and postprandial conditions and associated with carotid atherosclerosis. Methods. A cross-sectional study was conducted with 81 subjects, aged 56–80 years recruited from a population health survey. The participants underwent a fat tolerance test (1 g fat per Kg body weight) and ...

    • Chinese Herbal Medicines for the Treatment of Type A H1N1 Influenza : a Systematic Review of Randomized Controlled Trials 

      Chen, Wei; Lim, Chi Eung Danforn; Kang, Hong-Jun; Liu, Jianping (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Chinese herbs are thought to be effective for type A H1N1 influenza. Series of Chinese herbs have been authorized recommended by the Chinese government, and until now a number of clinical trials of Chinese herbs for H1N1 influenza have been conducted. However, there is no critically appraised evidence such as systematic reviews or metaanalyses on potential benefits and harms of medicinal herbs for ...

    • Prognostic Impacts of Angiopoietins in NSCLC Tumor Cells and Stroma : VEGF-A Impact Is Strongly Associated with Ang-2 

      Andersen, Sigve; Dønnem, Tom; Al-Shibli, Khalid Ibrahim; Al-Saad, Samer; Stenvold, Helge; Busund, Lill-Tove; Bremnes, Roy M. (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Angiopoietins and their receptor Tie-2 are, in concert with VEGF-A, key mediators in angiogenesis. This study evaluates the prognostic impact of all known human angiopoietins (Ang-1, Ang-2 and Ang-4) and their receptor Tie-2, as well as their relation to the prognostic expression of VEGF-A. 335 unselected stage I-IIIA NSCLC-patients were included and tissue samples of respective tumor cells and ...

    • Trauma research in low- and middle-income countries is urgently needed to strengthen the chain of survival 

      Wisborg, Torben; Montshiwa, Thapelo; Mock, Charles (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Trauma is a major - and increasing - cause of death, especially in low- and middle income countries. In all countries rural areas are especially hard hit, and the distribution of physicians is skewed towards cities. To reduce avoidable deaths from injury all links in the chain of survival after trauma needs strengthening. Prioritizing in each country should be done by local researchers, but little ...

    • Myocardial tissue Doppler velocities in fetuses with hypoplastic left heart syndrome. 

      Vyas, HV; Eidem, BW; Cetta, F; Acharya, Ganesh; Huhta, J.; Roberson, D; Cuneo, B (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Tissue Doppler Imaging (TDI) is a sensitive index of myocardial function. Its role in the fetus has not been extensively evaluated. To compare myocardial tissue Doppler velocities in fetuses with hypoplastic left heart syndrome (HLHS) to those of normal fetuses (matched for gestational age.) Cross-sectional retrospective study conducted at 2 large perinatal centers (2003-2007). Fetuses with HLHS ...

    • Can vitamin D-3 supplementation prevent bone loss in persons with MS? A placebo-controlled trial 

      Steffensen, Linn Hofsøy; Jørgensen, Lone; Straume, Bjørn; Mellgren, Svein Ivar; Kampman, Margitta Theodora (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Multiple sclerosis (MS) is a possible cause of secondary osteoporosis. In this phase II trial we assessed whether a weekly dose of 20,000 IU vitamin D3 prevents bone loss in ambulatory persons with MS age 18–50 years. ClinicalTrials.gov ID NCT00785473. All patients managed at the University Hospital of North Norway who fulfilled the main inclusion criteria were invited to participate in this ...

    • Would loss to follow-up bias the outcome evaluation of patients operated for degenerative disorders of the lumbar spine? 

      Solberg, Tore; Sørlie, Andreas; Sjåvik, Kristin; Nygaard, Øystein Petter; Ingebrigtsen, Tor (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Loss to follow-up may bias the outcome assessments of clinical registries. In this study, we wanted to determine whether outcomes were different in responding and non-responding patients who were included in a clinical spine surgery registry, at two years of follow-up. In addition, we wanted to identify risk factors for failure to respond. 633 patients who were operated for degenerative disorders ...

    • Air ambulance flights in northern Norway 2002- 2008. Increased number of secondary fixed wing (FW) operations and more use of rotor wing (RW) transports 

      Norum, Jan; Elsbak, Trond M (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Air ambulance service in Norway has been upgraded during the last years. European regulations concerning pilots’ working time and new treatment guidelines/strategies have called for more resources. The objective was to describe and analyse the two supplementary air ambulance [fixed wing (FW) and rotor wing (RW)] alternatives’ activity during the study period (2002-2008). Furthermore we aimed to ...

    • Can current prognostic scores reliably guide treatment decisions in patients with brain metastases from malignant melanoma? 

      Nieder, Carsten; Marienhagen, Kirsten; Geinitz, Hans; Grosu, Anca L. (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      We evaluated the performance of the new 4-tiered melanoma-specific graded prognostic assessment (GPA) score and the previously published general GPA score in patients with brain metastases from malignant melanoma managed with different approaches including best supportive care. Materials and Methods: Retrospective analysis of 51 patients. Compared with the original analysis of the melanoma-specific ...