Institutt for klinisk medisin: Nye registreringer

Viser treff 21-40 av 1974

    • High microRNA-145 plasma levels are associated with decreased risk of future incident venous thromboembolism: the HUNT study 

      Morelli, Vania Maris; Snir, Omri; Hindberg, Kristian Dalsbø; Hveem, Kristian; Brækkan, Sigrid Kufaas; Hansen, John Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-01-13)
      MicroRNA-145 (miR-145) has been reported to downregulate the expression of tissue factor and factor XI in vitro and decrease venous thrombus formation in animal models. However, the association between miR-145 and risk of future venous thromboembolism (VTE) in the general population remains unknown. We investigated the association between plasma levels of miR-145 and risk of future VTE in a case-cohort ...

    • Extending the Lund-Malmö creatinine-based GFR equation to cystatin C–validation results from the European Kidney Function Consortium (EKFC) cohort of children and adults 

      Björk, Jonas; Nyman, Ulf; Berg, Ulla; Bökenkamp, Arend; Cavalier, Etienne; Ebert, Natalie; Eriksen, Bjørn Odvar; Derain Dubourg, Laurence; Goffin, Karolien; Grubb, Anders; Hansson, Magnus; Larsson, Anders; Lemoine, Sandrine; Littmann, Karin; Mariat, Christophe; Melsom, Toralf; Schaeffner, Elke; Sundin, Per-Ola; Åsling-Monemi, Kajsa; Delanaye, Pierre; Pottel, Hans (Journal article; Tidsskriftartikkel; Peer reviewed, 2025-01-08)
      The aim of the present study was to extend the creatinine-based Lund-Malmö GFR equation for use with rescaled cystatin C (r-LMR<sub>Cys</sub>) and validate it against measured GFR (mGFR) in the EKFC cystatin C cohort of children (n = 2,293) and adults (n = 7,727). Rescaling was obtained by dividing each biomarker by a Q-value, representing the population-specific median biomarker level among healthy ...

    • Sex Differences in Presentation, Treatment, and Survival in Patients Receiving Palliative (Chemo)Radiotherapy for Non-Small Cell Lung Cancer 

      Nieder, Carsten; Aanes, Siv Gyda; Dalhaug, Astrid; Haukland, Ellinor Christin (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-12-30)
      Background/Aim: The aim of this study was to analyze sex differences in a real-world cohort of patients who received palliative thoracic radiotherapy or chemoradiotherapy for non-small cell lung cancer. <p> <p>Patients and Methods: Retrospectively, baseline, treatment, toxicity, and survival data from a single institution were analyzed. The study included 181 patients (82 females, 99 males). ...

    • Return to Work After Breast Cancer Treatment: An Electronic Health Record-based Study in North Norway 

      Nieder, Carsten; Haukland, Ellinor Christin; Mannsåker, Bård (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-06-26)
      Background/Aim: Breast cancer treatment may interfere with work ability. Previous return-to-work studies have often focused on participants who were invited to participate after treatment completion. Participation varied, resulting in potential selection bias. This is a health-record-based study evaluating data completeness, both at baseline and one year after diagnosis. Correlations between baseline ...

    • Palliative Radiation Treatment in Patients Managed With Advanced/Interventional Pain Therapy such as Pump-delivered Continuous Opioids 

      Nieder, Carsten; Jensen, Stine Maria F.; Nilsen, Solveig; Haukland, Ellinor Christin (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-09-30)
      Background/Aim: The study aim was to analyze the feasibility and efficacy of palliative radiotherapy in patients receiving advanced/interventional pain therapy, such as epidural or spinal anesthesia or subcutaneous pump delivery of opioids. Endpoints such as pain relief, treatment in the last month of life and survival were evaluated. <p> <p>Patients and Methods: Different baseline parameters ...

    • Real-World Survival Outcomes in Patients with Different Types of Cancer Managed with Immune Checkpoint Inhibitors 

      Nieder, Carsten; Aanes, Siv Gyda; Stanisavljevic, Luka; Mannsåker, Bård; Haukland, Ellinor Christin (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-12-04)
      Introduction: Immune checkpoint inhibitors (ICIs) are now standard of care in systemic treatment for many types of metastatic cancer, often together with cytotoxic chemotherapy. Monitoring of treatment efficacy against clinical trial benchmarks in real-world populations and subgroups such as elderly patients is necessary. Based on the results of a previous study, we evaluated age-related survival ...

    • Placenta-associated biomarkers and pregnancy outcome in HPA-1a alloimmunization: A prospective cohort study 

      Nedberg, Nora Hersoug; Nystad, Mona; Ahlen, Maria Therese; Bertelsen, eirin listau; Guz, Katarzyna; Uhrynowska, Małgorzata; Dębska, Marzena; Gierszon, Agnieszka; Orzińska, Agnieszka; Husebekk, Anne; Brojer, Ewa; Staff, Anne Cathrine; Tiller, Heidi (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-10-24)
      Introduction - Fetal and neonatal alloimmune thrombocytopenia (FNAIT) results from parental incompatibility in human platelet antigens (HPA) and subsequent maternal sensitization. The HPA-1a epitope is also expressed on placental tissue. Chronic placental inflammation and lower birth weight is observed more often in HPA-1a alloimmunized pregnancies, suggesting a placental component in the pathophysiology ...

    • Makten i tid - timing, rytme og tiden det tar 

      Fors, Malin (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-09-02)
      Timing er en fundamental etisk dimensjon i kliniske møter, uavhengig av terapimetode.

    • Transfemoral hepatic vein access in double vein embolization – initial experience and feasibility 

      Carling, Johan Ulrik; Berger, Sigurd; Gjønnæss, Eyvind; Røsok, Bård Ingvald; Yakub, Sheraz; Lassen, Kristoffer; Fretland, Åsmund Avdem; Dorenberg, Eric (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-09-03)
      Background Hepatic vein embolization in double vein embolization (DVE) can be performed with transhepatic, transjugular or transfemoral access. This study evaluates the feasibility and technical success of using a transfemoral access for the hepatic vein embolization in patients undergoing preoperative to induce hypertrophy of the future liver remnant (FLR).<p> <p>Material and methods ...

    • Cortisol and C-reactive protein (CRP) regulation in severe mental disorders 

      Inova, Amina; Birkenæs, Viktoria; Quintana, Daniel; Ormerod, Monica Bettina E. Greenwood; Ueland, Torill; Ueland, Thor; Djurovic, Srdjan; Andreassen, Ole; Steen, Nils Eiel; Aas, Monica (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-12-25)
      Background - People with schizophrenia (SZ) and bipolar disorder (BD) show abnormalities in the biological stress system and low-grade inflammation. However, whether the hypothalamic-pituitary-adrenal (HPA) axis-immune regulation is disrupted in SZ and BD, is yet to be determined.<p> <p>Methods - Cortisol and C-reactive protein (CRP) were measured in blood samples collected at or before 10 am in ...

    • Long Covid: a global health issue - a prospective, cohort study set in four continents 

      Pazukhina, Ekaterina; Garcia-Gallo, Esteban; Reyes, Luis Felipe; Kildal, Anders Benjamin; Jassat, Waasila; Dryden, Murray; Holter, Jan Cato; Chatterjee, Allegra; Gomez, Kyle; Søraas, Arne Vasli Lund; Puntoni, Matteo; Latronico, Nicola; Bozza, Fernando A; Edelstein, Michael; Gonçalves, Bronner P; Kartsonaki, Christiana; Kruglova, Oksana; Gaião, Sérgio; Chow, Yock Ping; Doshi, Yash; Duque Vallejo, Sara Isabel; Ibáñez-Prada, Elsa D; Fuentes, Yuli V; Hastie, Claire; O'Hara, Margaret E; Balan, Valeria; Menkir, Tigist; Merson, Laura; Kelly, Sadie; Citarella, Barbara Wanjiru; Semple, Malcolm G; Scott, Janet T; Munblit, Daniel; Sigfrid, Louise (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-10-21)
      Introduction - A proportion of people develop Long Covid after acute COVID-19, but with most studies concentrated in high-income countries (HICs), the global burden is largely unknown. Our study aims to characterise long-term COVID-19 sequelae in populations globally and compare the prevalence of reported symptoms in HICs and low-income and middle-income countries (LMICs).<p> <p>Methods - A ...

    • Patient cohorts of interest in resuscitation science - Aligning Cardiac Arrest Registry Outputs with Stakeholder Needs 

      Tjelmeland, Ingvild Beathe Myrhaugen; Alm-Kruse, Kristin; Andersson, Lars-Jøran; Larsen, Alf Inge; Lindner, Thomas Werner; Olasveengen, Theresa M.; Kramer-Johansen, Jo (Journal article; Tidsskriftartikkel; Peer reviewed, 2025-01-21)
      Cardiac arrest registries can benchmark, enhance quality of care and provide data for research. Key stakeholders from Emergency Medical Communication Centre (EMCC), Emergency Medical Services (EMS), In-Hospital Care Providers (IHCP) and Recovery and Rehabilitation Providers (RRP) have different perspectives, and registry results and patient cohorts should be tailored to facilitate benchmarking, ...

    • Repeat traumatic brain injury exacerbates acute thalamic hyperconnectivity in humans 

      Woodrow, Rebecca E; Menon, David K.; Stamatakis, Emmanuel A; Amrein, Krisztina; Andelic, Nada; Andreassen, Lasse; Anke, Audny; Azouvi, Philippe; Bellander, Bo-Michael; Benali, Habib; Buki, Andras; Caccioppola, Alessio; Calappi, Emiliana; Carbonara, Marco; Citerio, Giuseppe; Clusmann, Hans; Coburn, Mark; Coles, Jonathan; Correia, Marta; Czeiter, Endre; De Keyser, Véronique; Degos, Vincent; Depreitere, Bart; Eikenes, Live; Ezer, Erzsébet; Foks, Kelly; K Frisvold, Shirin; Galanaud, Damien; Ghuysen, Alexandre; Glocker, Ben; Håberg, Asta; Haitsma, Iain; Helseth, Eirik; Hutchinson, Peter J; Kornaropoulos, Evgenios; Kovács, Noémi; Kowark, Ana; Laureys, Steven; Ledoux, Didier; Lingsma, Hester; Maas, Andrew IR; Manley, Geoffrey; Menon, David K; Menovsky, Tomas; Misset, Benoit; Muraleedharan, Visakh; Nakken, Ingeborg; Newcombe, Virginia; Nordhøy, Wibeke; Skandsen, Toril; Vik, Anne (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-06-28)
      Repeated mild traumatic brain injury is of growing interest regarding public and sporting safety and is thought to have greater adverse or cumulative neurological effects when compared with single injury. While epidemiological links between repeated traumatic brain injury and outcome have been investigated in humans, exploration of its mechanistic substrates has been largely undertaken in animal ...

    • European S2k guidelines for hidradenitis suppurativa/acne inversa part 2: Treatment 

      Zouboulis, C.C.; Bechara, F.G.; Benhadou, F.; Bettoli, V.; Bukvić Mokos, Mokos; Del Marmol, Marmol; Dolenc-Voljč, M.; Giamarellos-Bourboulis, E.J.; Grimstad, Øystein; Guillem, P.; Horváth, B.; Hunger, R.E.; Ingram, J.R.; Ioannidis, D.; Just, E.; Kemény, L.; Kirby, B.; Liakou, A.I.; McGrath, B.M.; Marzano, A.V.; Matusiak, L.; Molina-Leyva, A.; Nassif, A.; Podda, M.; Prens, E.P.; Prignano, F.; Raynal, H.; Romanelli, M.; Saunte, D.M.L.; Szegedi, A.; Szepietowski, J.C.; Tzellos, Thrasyvoulos; Valiukevičienė, S.; van der Zee, der; van Straalen, Straalen; Villumsen, B.; Jemec, G.B.E. (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-12-19)
      Introduction: This second part of the S2k guidelines is an update of the 2015 S1 European guidelines.<p> <p>Objective: These guidelines aim to provide an accepted decision aid for the selection, implementation and assessment of appropriate and sufficient therapy for patients with hidradenitis suppurativa/acne inversa (HS). <p>Methods: The chapters have been selected after a Delphi procedure among ...

    • The hidden impact of GLP-1 receptor agonists on endometrial receptivity and implantation 

      Sola-Leyva, Alberto; Pathare, Amruta D. S.; Apostolov, Apostol; Aleksejeva, Elina; Kask, Keiu; Tammiste, Triin; Ruiz-Durán, Susana; Risal, Sanjiv; Acharya, Ganesh Prasad; Salumets, Andres (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-12-18)
      Increasing infertility rates represent a growing medical challenge in modern societies resulting from a complex interplay of sociocultural trends, lifestyle factors, exposure to environmental toxins, and underlying health problems. Women's fertility is particularly vulnerable to these shifts. The obesogenic lifestyle not only accelerates weight gain, but also disrupts ovulation driving the ...

    • One-Year Insights into the GLOBOSTAD Multinational Prospective Observational Study of Patients Receiving Dupilumab for Atopic Dermatitis 

      Calzavara-Pinton, Piergiacomo; Chu, Chia-Yu; Lapeere, Hilde; Rossi, Mariateresa; Ferrucci, Silvia M.; Chung, Wen-Hung; Fougerousse, Anne-Claire; Fomina, Daria S.; Holzer, Gregor; Čelakovská, Jarmila; Al-Ahmad, Mona; Tzellos, Thrasyvoulos; Wu, Jiangming; Ardeleanu, Marius; Bosman, Kwinten (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-12-02)
      Introduction Currently, limited data are available on long-term use of dupilumab to treat atopic dermatitis (AD) in a multinational real-world setting. The aim of this analysis was to report the interim 1-year data for patients with AD enrolled in the GLOBOSTAD registry, including treatment patterns, dupilumab effectiveness and safety, and healthcare burden.<p> <p>Methods GLOBOSTAD is an ongoing, ...

    • Spotlight on the 2024 ESC/EACTS management of atrial fibrillation guidelines: 10 novel key aspects 

      Rienstra, Michiel; Tzeis, Stylianos; Bunting, Karina V.; Caso, Valeria; Crijns, Harry J. G M.; De Potter, Tom J. R.; Sanders, Prashanthan; Svennberg, Emma; Casado-Arroyo, Ruben; Dwight, Jeremy; Guasti, Luigina; Hanke, Thorsten; Jaarsma, Tiny; Lettino, Maddalena; Løchen, Maja-Lisa; Lumbers, R Thomas; Maesen, Bart; Mølgaard, Inge; Rosano, Giuseppe M. C.; Schnabel, Renate B.; Suwalski, Piotr; Tamargo, Juan; Tica, Otilia; Traykov, Vassil; Kotecha, Dipak; Van Gelder, Isabelle C. (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-12-24)
      Atrial fibrillation (AF) remains the most common cardiac arrhythmia worldwide and is associated with significant morbidity and mortality. The European Society of Cardiology (ESC)/European Association for Cardio-Thoracic Surgery (EACTS) have recently released the 2024 guidelines for the management of AF. This review highlights 10 novel aspects of the ESC/EACTS 2024 Guidelines. The AF-CARE framework ...

    • Disparities in casemix, acute interventions, discharge destinations and mortality of patients with traumatic brain injury between Europe and India 

      Gupta, Deepak; Singh, Ranjit D.; Vreeburg, Rick Jg; van Dijck, Jeroen T.J.M.; Boogert, Hugo den; Sharma, Kaveri; Praneeth, Kokkula; Clarke, David B.; Lecky, Fiona E.; Maas, Andrew IR; Sinha, Virendra Deo; Ruiter, Godard Cw de; Peul, Wilco C.; Van Essen, Thomas A.; Åkerlund, Cecilia; Amrein, Krisztina; Andelic, Nada; Andreassen, Lasse; Anke, Audny Gabriele Wagner; Antoni, Anna; Audibert, Gérard; Azouvi, Philippe; Azzolini, Maria Luisa; Bartels, Ronald; Barzó, Pál; Beauvais, Romuald; Beer, Ronny; Bellander, Bo-Michael; Belli, Antonio; Benali, Habib; Berardino, Maurizio; Beretta, Luigi; Blaabjerg, Morten; Bragge, Peter; Brazinova, Alexandra; Brinck, Vibeke; Brooker, Joanne; Brorsson, Camilla; Buki, Andras; Bullinger, Monika; Cabeleira, Manuel; Caccioppola, Alessio; Calappi, Emiliana; Calvi, Maria Rosa; Cameron, Peter; Lozano, Guillermo Carbayo; Carbonara, Marco; Cavallo, Simona; Chevallard, Giorgio; Chieregato, Arturo; Citerio, Giuseppe; Clusmann, Hans; Coburn, Mark; Coles, Jonathan; Cooper, Jamie D.; Correia, Marta; Čović, Amra; Curry, Nicola; Czeiter, Endre; Czosnyka, Marek; Fizelier, Claire Dahyot; Dark, Paul; Dawes, Helen; De Keyser, Véronique; Degos, Vincent; Corte, Francesco Della; Depreitere, Bart; Đilvesi, Đula; K Frisvold, Shirin; Helseth, Eirik; Røe, Cecilie; Røise, Olav; Skandsen, Toril; Vik, Anne (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-11-11)
      Background - Traumatic brain injury (TBI) is a major global health problem that disproportionally affects low- and middle-income countries. The needs for patients with TBI therefore may differ between levels of national development. We aimed to describe differences in epidemiology and acute care provision of TBI between India and Europe.<p> <p>Methods - We used data from two prospective observational ...

    • Parsimonious immune-response endotypes and global outcome in patients with traumatic brain injury 

      Samanta, Romit J; Chiollaz, Anne-Cécile; Needham, Edward; Yue, John K; Helmy, Adel; Zanier, Elisa R.; Wang, Kevin K W; Kobeissy, Firas; Posti, Jussi P.; Summers, Charlotte; Manley, Geoffrey T; Maas, Andrew IR; Tenovuo, Olli; Sanchez, Jean-Charles; Menon, David K; Badjatia, Neeraj; Diaz-Arrastia, Ramon; Duhaime, Ann-Christine; Feeser, V Ramana; Gopinath, Shankar; Grandhi, Ramesh; Ha, Ruchira J; Keene, Dirk; Madden, Christopher; McCrea, Michael; Merchant, Randall; Ngwenya, Laura B; Rodgers, Richard B; Schnyer, David; Taylor, Sabrina R.; Zafonte, Ross; Ackerlund, Cecilia; Amrein, Krisztina; Andelic, Nada; Andreassen, Lasse; Anke, Audny Gabriele Wagner; Audibert, Gérard; Azouvi, Philippe; Azzolini, Maria Luisa; Bartels, Ronald; Beer, Ronny; Bellander, Bo-Michael; Benali, Habib; Berardino, Maurizio; Beretta, Luigi; Beqiri, Erta; Blaabjerg, Morten; Lund, Stine Borgen; Brorsson, Camilla; Buki, Andras; Cabeleira, Manuel; Caccioppola, Alessio; Calappi, Emiliana; Calvi, Maria Rosa; Helseth, Eirik; K Frisvold, Shirin; Røe, Cecilie; Røise, Olav; Skandsen, Toril; Sandrød, Oddrun; Vik, Anne (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-09-17)
      Background - The inflammatory response in patients with traumatic brain injury (TBI) offers opportunities for stratification and intervention. Previous unselected approaches to immunomodulation in patients with TBI have not improved patient outcomes.<p> <p>Methods - Serum and plasma samples from two prospective, multi-centre observational studies of patients with TBI were used to discover ...

    • Association of early blood-based biomarkers and six-month functional outcomes in conventional severity categories of traumatic brain injury: capturing the continuous spectrum of injury 

      Wilson, Lindsay; Newcombe, Virginia FJ; Whitehouse, Daniel P; Mondello, Stefania; Maas, Andrew I. R.; Menon, David K.; Ackerlund, Cecilia; Amrein, Krisztina; Andelic, Nada; Andreassen, Lasse; Anke, Audny Gabriele Wagner; Antoni, Anna; Audibert, Gérard; Azouvi, Philippe; Azzolini, Maria Luisa; Bartels, Ronald; Barzó, Pál; Beauvais, Romuald; Beer, Ronny; Bellander, Bo-Michael; Belli, Antonio; Benali, Habib; Berardino, Maurizio; Beretta, Luigi; Blaabjerg, Morten; Bragge, Peter; Brazinova, Alexandra; Brinck, Vibeke; Brooker, Joanne; Brorsson, Camilla; Büki, András; Bullinger, Monika; Cabeleira, Manuel; Caccioppola, Alessio; Calappi, Emiliana; Calvi, Maria Rosa; Cameron, Peter; Carbayo Lozano, Guillermo; Carbonara, Marco; Castaño-León, Ana M.; Cavallo, Simona; Chevallard, Giorgio; Chieregato, Arturo; Citerio, Guiseppe; Clusmann, Hans; Coburn, Mark Steven; K Frisvold, Shirin; Helseth, Eirik; Røe, Cecilie; Røise, Olav; Skandsen, Toril; Vik, Anne (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-08-26)
      Background - Traumatic brain injury is conventionally categorised as mild, moderate, or severe on the Glasgow Coma Scale (GCS). Recently developed biomarkers can provide more objective and nuanced measures of the extent of brain injury.<p> <p>Methods - Exposure–response relationships were investigated in 2479 patients aged ≥16 enrolled in the Collaborative European NeuroTrauma Effectiveness ...