Institutt for klinisk medisin: Nye registreringer
Viser treff 441-460 av 1804
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Levels of Peripheral Circulating IL-6 and IL-10 Decrease Over Time Despite High Depression Burden in PTSD Patients
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-04-05)Background: Patients with combined depression symptoms and post-traumatic stress disorder (PTSD) often exhibit high levels of circulating inflammatory biomarkers as either a cause or consequence of their disease. We aimed to investigate how cytokines and depression symptoms develop with one-year follow-up and compare them with non-PTSD patients.<p> <p>Methods: The study had a longitudinal design ... -
Retinal vascular calibre and response to light exposure and serial imaging
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013-07-04)Purpose: To investigate whether retinal vessel calibre measurements on optical retinal photography are affected by light and dark exposure prior to photography and whether the vessel calibre changes during an imaging sequence of several images. <p>Methods: Digital optical retinal photographs were obtained from 32 healthy adults in two separate image sequences of six images during 1 min; one ... -
Changes in the secretory profile of NSCLC-associated fibroblasts after ablative radiotherapy: Potential impact on angiogenesis and tumor growth
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014-03-05)In the context of radiotherapy, collateral effects of ablative ionizing radiation (AIR) on stromal components of tumors remains understudied. In this work, cancer-associated fibroblasts (CAFs) isolated from freshly resected human lung tumors were exposed to AIR (1x18Gy) and analyzed for their release of paracrine factors. Inflammatory mediators and regulators of angiogenesis and tumor growth were ... -
Palliative non-small cell lung cancer treatment and end-of-life care stratified by sex and childlessness: an important interplay in unmarried patients?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-22)Purpose To analyze the interplay of sex and presence of children in unmarried patients with non-small cell lung cancer, because previous studies suggested sex-related disparities. Adult children may participate in treatment decisions and provision of social support or home care.<p> <p>Methods Retrospective single-institution analysis of 186 unmarried deceased patients, managed according to ... -
Risk of venous thromboembolism from use of oral contraceptives containing different progestogens and oestrogen doses: Danish cohort study, 2001-9
(Journal article; Tidsskriftartikkel; Peer reviewed, 2011-10-25)Objective To assess the risk of venous thromboembolism from use of combined oral contraceptives according to progestogen type and oestrogen dose.<p> <p>Design National historical registry based cohort study. <p>Setting Four registries in Denmark. <p>Participants Non-pregnant Danish women aged 15-49 with no history of thrombotic disease and followed from January 2001 to December 2009. <p>Main ... -
Impact of hidradenitis suppurativa on work loss, indirect costs and income
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-08-18)Background Hidradenitis suppurativa (HS), a chronic cutaneous disease, can negatively affect work life. Objectives This retrospective cohort study evaluates the indirect burden among employed patients with HS in the U.S.A.<p> <p>Methods Newly diagnosed and general patients with HS, who were employees (age 18–64 years) from a large claims database (Q1 1999 to Q1 2015), were matched 1 : 5 to ... -
Association of vitamin D status with arterial blood pressure and hypertension risk: A mendelian randomisation study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014-06-25)Background Low plasma 25-hydroxyvitamin D (25[OH]D) concentration is associated with high arterial blood pressure and hypertension risk, but whether this association is causal is unknown. We used a mendelian randomisation approach to test whether 25(OH)D concentration is causally associated with blood pressure and hypertension risk.<p> <p>Methods In this mendelian randomisation study, we generated ... -
Socioeconomic and geographic differences in ablation of atrial fibrillation in Norway - a national cohort study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-14)<p><i>Background -</i> The aim of this study was to analyse whether there are patient related or geographic differences in the use of catheter ablation among atrial fibrillation patients in Norway. <p><i>Methods -</i> National population-based data on individual level of all Norwegians aged 25 to 75 diagnosed with atrial fibrillation from 2008 to 2017 were used to study the proportion treated with ... -
Cellular and molecular mediators of intestinal fibrosis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-11-02)Intestinal fibrosis is a major complication of the inflammatory bowel diseases (IBD) and although inflammation is necessary for its development, it would appear that it plays a minor role in its progression as anti-inflammatory treatments in IBD do not prevent fibrosis once it has started. The processes that regulate fibrosis would thus appear to be distinct from those regulating inflammation and, ... -
Poor prognosis patients with inoperable locally advanced NSCLC and large tumors benefit from palliative chemoradiotherapy: A subset analysis from a randomized clinical phase III trial
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-11-20)Introduction: Poor prognosis patients with bulky stage III locally advanced non–small-cell lung cancer may not be offered concurrent chemoradiotherapy (CRT). Following a phase III trial concerning the effect of palliative CRT in inoperable poor prognosis patients, this analysis was performed to explore how tumor size influenced survival and health-related quality of life (HRQOL).<p> <p>Methods: ... -
On the formation of 7-ketocholesterol from 7-dehydrocholesterol in patients with CTX and SLO
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014-04-25)Abstract A new mechanism for formation of 7-ketocholesterol was recently described involving cytochrome P-450 (CYP)7A1-catalyzed conversion of 7-dehydrocholesterol into 7-ketocholesterol with cholesterol-7,8-epoxide as a side product. Some patients with cerebrotendinous xanthomatosis (CTX) and all patients with Smith-Lemli-Opitz syndrome (SLO) have markedly increased levels of 7-dehydrocholesterol ... -
Protein homeostasis in LGMDR9 (LGMD2I) – The role of ubiquitin‐proteasome and autophagy‐lysosomal system
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-18)Aims: Limb-girdle muscular dystrophy R9 (LGMDR9) is an autosomal recessive disorder caused by mutations in the fukutin-related protein gene (FKRP), encoding a glycosyltransferase involved in α-dystroglycan modification. Muscle atrophy, a significant feature of LGMDR9, occurs by a change in the normal balance between protein synthesis and protein degradation. The ubiquitin–proteasome system (UPS) ... -
Concurrent palliative chemoradiation leads to survival and quality of life benefits in poor prognosis stage III non-small-cell lung cancer: a randomised trial by the Norwegian Lung Cancer Study Group
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013-08-20)Background: The palliative role of chemoradiation in the treatment of patients with locally advanced, inoperable non-small-cell lung cancer stage III and negative prognostic factors remains unresolved.<p> <p>Methods: Patients not eligible for curative radiotherapy were randomised to receive either chemoradiation or chemotherapy alone. Four courses of intravenous carboplatin on day 1 and oral ... -
Integrating mental health into primary care in Arkhangelsk County, Russia: the Pomor model in psychiatry
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-13)Background: Primary health care is still peripheral in the identifcation and treatment of mental health and substance use disorders in the Russian Federation. However, the development of primary health services has been given priority. A long-standing collaboration between Arkhangelsk County and northern Norway on mental health service development in Arkhangelsk has promoted the integration of ... -
Consanguinity and rare mutations outside of MCCC genes underlie nonspecific phenotypes of MCCD
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014-11-06)Purpose: 3-Methylcrotonyl-CoA carboxylase deficiency (MCCD) is an autosomal recessive disorder of leucine catabolism that has a highly variable clinical phenotype, ranging from acute metabolic acidosis to nonspecific symptoms such as developmental delay, failure to thrive, hemiparesis, muscular hypotonia, and multiple sclerosis. Implementation of newborn screening for MCCD has resulted in broadening ... -
Importation of roughage to Norway - Implications for plant and animal health, zoonoses, and biodiversity. Opinion of the scientific committee of the Norwegian Scientific Committee for Food and Enviroment
(Research report; Forskningsrapport, 2022-02-18)Det er stor usikkerhet om import av grovfôr til Norge kan føre med seg planteskadegjørere, invaderende planter og smittestoff som kan forårsake sykdom hos dyr og mennesker. -
Single use negative-pressure wound therapy compared to standard care in patients after carbon dioxide laser surgery for hidradenitis suppurativa
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-04-03)Negative pressure wound therapy is a commonly used treatment modality for surgi-cal wounds healing by secondary intention. In an open, split side study with12 patients, we compared low negative pressure wound therapy to conventionalfoam dressing the first postoperative week after carbon dioxide laser vaporization ofhidradenitis suppurativa lesions. The primary outcome was time to complete woundhealing, ... -
Vedvarende bruk av opioider og samtidig bruk av andre vanedannende legemidler
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-14)BAKGRUNN<p> Vedvarende bruk av opioider kan ha uheldige konsekvenser. Vi har undersøkt vedvarende opioidbruk i pasientgruppersom fikk forskrevet opioider på ulike indikasjoner(langvarig smerte, palliativ behandling, andre (hvitresept)),samt gruppenessamtidige bruk av enkelte andre vanedannende legemidler.<p> MATERIALE OG METODE<p> <p>Personer med minst én utlevering av et opioid i Reseptregisteret ... -
NT-ProBNP and high-sensitivity troponin T as screening tests for subclinical chronic heart failure in a general population
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-23)Aims The aim of this study was to establish age-specific and sex-specific cut-off values for N-terminal pro-brain natriuretic peptide (NT-proBNP) and high-sensitivity troponin T (hs-troponin T) in healthy subjects and assess cardiac biomarkers as screening tools for subclinical heart failure (HF) in a general population.<p> <p>Methods and results Altogether, 1936 participants were randomly selected ... -
Cancer survivors' experiences of humour while navigating through challenging landscapes - a socio-narrative approach
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-03-10)Aim: Humour is seen as a health-promoting coping strategy when dealing with life stress. The aim is to elucidate how adult cancer survivors experience and evaluate the significance of humour in daily life, from diagnosis through their entire illness trajectory, and to gain a broader understanding of humour as part of stress-coping processes during the experience of cancer as a life-threatening ...